CCC2/YDR270W Literature Guide Help

Other names published for CCC2: Cu(2+)-transporting P-type ATPase CCC2, YDR270W

CCC2 - Strains/Constructs (27)

ReferenceOther Genes Addressed
Heo DH, et al.  (2012) Cd2+ binds to Atx1 and affects the physical interaction between Atx1 and Ccc2 in Saccharomyces cerevisiae. Biotechnol Lett 34(2):303-7
Tani M and Kuge O  (2012) Hydroxylation state of fatty acid and long-chain base moieties of sphingolipid determine the sensitivity to growth inhibition due to AUR1 repression in Saccharomyces cerevisiae. Biochem Biophys Res Commun 417(2):673-8
Kavun Ozbayraktar FB and Ulgen KO  (2011) Stoichiometric network reconstruction and analysis of yeast sphingolipid metabolism incorporating different states of hydroxylation. Biosystems 104(1):63-75
Valverde RH, et al.  (2011) Two Serine Residues Control Sequential Steps during Catalysis of the Yeast Copper ATPase through Different Mechanisms That Involve Kinase-mediated Phosphorylations. J Biol Chem 286(9):6879-89
Ishizaki H, et al.  (2010) Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation. Dis Model Mech 3(9-10):639-51
Kennerson ML, et al.  (2010) Missense Mutations in the Copper Transporter Gene ATP7A Cause X-Linked Distal Hereditary Motor Neuropathy. Am J Hum Genet 86(3):343-352
Morin I, et al.  (2009) Dissecting the role of the N-terminal metal-binding domains in activating the yeast copper ATPase in vivo. FEBS J 276(16):4483-95
Ruotolo R, et al.  (2008) Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast. Genome Biol 9(4):R67
Tang J, et al.  (2008) Clinical outcomes in Menkes disease patients with a copper-responsive ATP7A mutation, G727R. Mol Genet Metab 95(3):174-81
Valverde RH, et al.  (2008) Cyclic AMP-dependent protein kinase controls energy interconversion during the catalytic cycle of the yeast copper-ATPase. FEBS Lett 582(6):891-5
Donsante A, et al.  (2007) Differences in ATP7A gene expression underlie intrafamilial variability in Menkes disease/occipital horn syndrome. J Med Genet 44(8):492-7
Doostzadeh J, et al.  (2007) Chemical genomic profiling for identifying intracellular targets of toxicants producing Parkinson's disease. Toxicol Sci 95(1):182-7
Morin I, et al.  (2005) Cd2+- or Hg2+-binding proteins can replace the Cu+-chaperone Atx1 in delivering Cu+ to the secretory pathway in yeast. FEBS Lett 579(5):1117-23
Portmann R and Solioz M  (2005) Purification and functional reconstitution of the human Wilson copper ATPase, ATP7B. FEBS Lett 579(17):3589-95
van Bakel H, et al.  (2005) Gene expression profiling and phenotype analyses of S. cerevisiae in response to changing copper reveals six genes with new roles in copper and iron metabolism. Physiol Genomics 22(3):356-67
Hsi G, et al.  (2004) Functional assessment of the carboxy-terminus of the Wilson disease copper-transporting ATPase, ATP7B. Genomics 83(3):473-81
Lowe J, et al.  (2004) A mutational study in the transmembrane domain of Ccc2p, the yeast Cu(I)-ATPase, shows different roles for each Cys-Pro-Cys cysteine. J Biol Chem 279(25):25986-94
Serrano R, et al.  (2004) Copper and iron are the limiting factors for growth of the yeast Saccharomyces cerevisiae in an alkaline environment. J Biol Chem 279(19):19698-704
Southron JL, et al.  (2004) Complementation of Saccharomyces cerevisiae ccc2 mutant by a putative P1B-ATPase from Brassica napus supports a copper-transporting function. FEBS Lett 566(1-3):218-22
van Dongen EM, et al.  (2004) Copper-dependent protein-protein interactions studied by yeast two-hybrid analysis. Biochem Biophys Res Commun 323(3):789-95
El Meskini R, et al.  (2003) Supplying copper to the cuproenzyme peptidylglycine alpha-amidating monooxygenase. J Biol Chem 278(14):12278-84
Mercer JF, et al.  (2003) Copper-induced trafficking of the cU-ATPases: a key mechanism for copper homeostasis. Biometals 16(1):175-84
Steinmetz LM, et al.  (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4
Weissman Z, et al.  (2002) Deletion of the copper transporter CaCCC2 reveals two distinct pathways for iron acquisition in Candida albicans. Mol Microbiol 44(6):1551-60
Forbes JR and Cox DW  (2000) Copper-dependent trafficking of Wilson disease mutant ATP7B proteins. Hum Mol Genet 9(13):1927-35
Fu D, et al.  (1995) Sequence, mapping and disruption of CCC2, a gene that cross-complements the Ca(2+)-sensitive phenotype of csg1 mutants and encodes a P-type ATPase belonging to the Cu(2+)-ATPase subfamily. Yeast 11(3):283-92
Yuan DS, et al.  (1995) The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake. Proc Natl Acad Sci U S A 92(7):2632-6