GCN2/YDR283C Literature Guide Help

Other names published for GCN2: AAS1, NDR2, AAS102, YDR283C

GCN2 - Regulatory Role (39)

Results: 1 - 30 of 39 records
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ReferenceOther Genes Addressed
Rodriguez-Hernandez CJ, et al.  (2012) Anti-diabetic and anti-obesity agent sodium tungstate enhances GCN pathway activation through Glc7p inhibition. FEBS Lett 586(3):270-6
Dey M, et al.  (2011) Requirement for kinase-induced conformational change in eukaryotic initiation factor 2alpha (eIF2alpha) restricts phosphorylation of Ser51. Proc Natl Acad Sci U S A 108(11):4316-21
Molin M, et al.  (2011) Life Span Extension and H(2)O(2) Resistance Elicited by Caloric Restriction Require the Peroxiredoxin Tsa1 in Saccharomyces cerevisiae. Mol Cell 43(5):823-33
Cherkasova V, et al.  (2010) Snf1 promotes phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4. Mol Cell Biol 30(12):2862-73
Ecker N, et al.  (2010) Induction of autophagic flux by amino acid deprivation is distinct from nitrogen starvation-induced macroautophagy. Autophagy 6(7):879-90
Nomura W, et al.  (2010) Methylglyoxal activates Gcn2 to phosphorylate eIF2alpha independently of the TOR pathway in Saccharomyces cerevisiae. Appl Microbiol Biotechnol 86(6):1887-94
Staschke KA, et al.  (2010) Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast. J Biol Chem 285(22):16893-911
Zaborske JM, et al.  (2010) Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae. BMC Biochem 11():29
Garriz A, et al.  (2009) A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2. Mol Cell Biol 29(6):1592-607
Zaborske JM, et al.  (2009) Genome-wide Analysis of tRNA Charging and Activation of the eIF2 Kinase Gcn2p. J Biol Chem 284(37):25254-67
Zamdborg L and Ma P  (2009) Discovery of protein-DNA interactions by penalized multivariate regression. Nucleic Acids Res 37(16):5246-54
Mascarenhas C, et al.  (2008) Gcn4 Is Required for the Response to Peroxide Stress in the Yeast Saccharomyces cerevisiae. Mol Biol Cell 19(7):2995-3007
Nomura W, et al.  (2008) Role of Gcn4 for adaptation to methylglyoxal in Saccharomyces cerevisiae: methylglyoxal attenuates protein synthesis through phosphorylation of eIF2alpha. Biochem Biophys Res Commun 376(4):738-42
Menacho-Marquez M, et al.  (2007) Gcn2p regulates a G1/S cell cycle checkpoint in response to DNA damage. Cell Cycle 6(18):2302-5
Peter GJ, et al.  (2006) Carbon catabolite repression regulates amino acid permeases in Saccharomyces cerevisiae via the TOR signaling pathway. J Biol Chem 281(9):5546-52
Shenton D, et al.  (2006) Global Translational Responses to Oxidative Stress Impact upon Multiple Levels of Protein Synthesis. J Biol Chem 281(39):29011-21
Patil CK, et al.  (2004) Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response. PLoS Biol 2(8):E246
Braus GH, et al.  (2003) Amino acid starvation and Gcn4p regulate adhesive growth and FLO11 gene expression in Saccharomyces cerevisiae. Mol Biol Cell 14(10):4272-84
Cherkasova VA and Hinnebusch AG  (2003) Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2. Genes Dev 17(7):859-72
Miyamoto Y, et al.  (2002) Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A. J Biol Chem 277(32):28810-4
Clemens MJ  (2001) Initiation factor eIF2 alpha phosphorylation in stress responses and apoptosis. Prog Mol Subcell Biol 27():57-89
Goossens A, et al.  (2001) The protein kinase Gcn2p mediates sodium toxicity in yeast. J Biol Chem 276(33):30753-60
Grundmann O, et al.  (2001) Repression of GCN4 mRNA translation by nitrogen starvation in Saccharomyces cerevisiae. J Biol Chem 276(28):25661-71
Marbach I, et al.  (2001) Gcn2 mediates Gcn4 activation in response to glucose stimulation or UV radiation not via GCN4 translation. J Biol Chem 276(20):16944-51
Kubota H, et al.  (2000) GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast. J Biol Chem 275(27):20243-6
Yang R, et al.  (2000) Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase. Mol Cell Biol 20(8):2706-17
Rolfes RJ and Hinnebusch AG  (1993) Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2. Mol Cell Biol 13(8):5099-111
Dever TE, et al.  (1992) Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Cell 68(3):585-96
Lanker S, et al.  (1992) Autoregulation of the yeast lysyl-tRNA synthetase gene GCD5/KRS1 by translational and transcriptional control mechanisms. Cell 70(4):647-57
Ramirez M, et al.  (1992) Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases. Mol Cell Biol 12(12):5801-15
Results: 1 - 30 of 39 records
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