CDC34/YDR054C Literature Guide Help

Other names published for CDC34: DNA6, UBC3, SCF E2 ubiquitin-protein ligase catalytic subunit CDC34, YDR054C

CDC34 - Regulatory Role (28)

ReferenceOther Genes Addressed
Khong JH, et al.  (2012) "Reductional anaphase" in replication-defective cells is caused by ubiquitin-conjugating enzyme Cdc34-mediated deregulation of the spindle. Cell Cycle 11(15):2896-910
Cappell SD, et al.  (2010) Systematic analysis of essential genes reveals important regulators of G protein signaling. Mol Cell 38(5):746-57
Hwang GW, et al.  (2008) The ubiquitin-conjugating enzymes, Ubc4 and Cdc34, mediate cadmium resistance in budding yeast through different mechanisms. Life Sci 82(23-24):1182-5
Li Z, et al.  (2008) Cdc34p Ubiquitin-Conjugating Enzyme Is a Component of the Tombusvirus Replicase Complex and Ubiquitinates p33 Replication Protein. J Virol 82(14):6911-26
Pal B, et al.  (2007) SCFCdc4-mediated degradation of the Hac1p transcription factor regulates the unfolded protein response in Saccharomyces cerevisiae. Mol Biol Cell 18(2):426-40
Sadowski M, et al.  (2007) Cdc34 C-terminal tail phosphorylation regulates Skp1/cullin/F-box (SCF)-mediated ubiquitination and cell cycle progression. Biochem J 405(3):569-81
Jackson LP, et al.  (2006) Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6. Mol Cell Biol 26(6):2456-66
Varelas X, et al.  (2006) The Cdc34/SCF Ubiquitination Complex Mediates Saccharomyces cerevisiae Cell Wall Integrity. Genetics 174(4):1825-39
Gardner RG, et al.  (2005) Degradation-mediated protein quality control in the nucleus. Cell 120(6):803-15
Horak J and Wolf DH  (2005) The ubiquitin ligase SCF(Grr1) is required for Gal2p degradation in the yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun 335(4):1185-90
Bao MZ, et al.  (2004) Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast. Cell 119(7):991-1000
Wang Y, et al.  (2003) Regulation of Ste7 ubiquitination by Ste11 phosphorylation and the Skp1-Cullin-F-box complex. J Biol Chem 278(25):22284-9
Wheeler GL, et al.  (2002) Glutathione regulates the expression of gamma-glutamylcysteine synthetase via the Met4 transcription factor. Mol Microbiol 46(2):545-56
Gordon DM and Roof DM  (2001) Degradation of the kinesin Kip1p at anaphase onset is mediated by the anaphase-promoting complex and Cdc20p. Proc Natl Acad Sci U S A 98(22):12515-20
Miller ME and Cross FR  (2001) Mechanisms controlling subcellular localization of the G(1) cyclins Cln2p and Cln3p in budding yeast. Mol Cell Biol 21(18):6292-311
Kaiser P, et al.  (2000) Regulation of transcription by ubiquitination without proteolysis: Cdc34/SCF(Met30)-mediated inactivation of the transcription factor Met4. Cell 102(3):303-14
Kaplun L, et al.  (2000) Functions of the DNA damage response pathway target Ho endonuclease of yeast for degradation via the ubiquitin-26S proteasome system. Proc Natl Acad Sci U S A 97(18):10077-82
Meimoun A, et al.  (2000) Degradation of the transcription factor Gcn4 requires the kinase Pho85 and the SCF(CDC4) ubiquitin-ligase complex. Mol Biol Cell 11(3):915-27
Rouillon A, et al.  (2000) Feedback-regulated degradation of the transcriptional activator Met4 is triggered by the SCF(Met30 )complex. EMBO J 19(2):282-94
Schwer B, et al.  (2000) Structure-function analysis of yeast mRNA cap methyltransferase and high-copy suppression of conditional mutants by AdoMet synthase and the ubiquitin conjugating enzyme Cdc34p. Genetics 155(4):1561-76
Patton EE, et al.  (1998) Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Trends Genet 14(6):236-43
Zhou P and Howley PM  (1998) Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases. Mol Cell 2(5):571-80
Feldman RM, et al.  (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91(2):221-30
Verma R, et al.  (1997) SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities. Mol Biol Cell 8(8):1427-37
Blondel M and Mann C  (1996) G2 cyclins are required for the degradation of G1 cyclins in yeast. Nature 384(6606):279-82
Kornitzer D, et al.  (1994) Regulated degradation of the transcription factor Gcn4. EMBO J 13(24):6021-30
Haas AL, et al.  (1991) Ubiquitin conjugation by the yeast RAD6 and CDC34 gene products. Comparison to their putative rabbit homologs, E2(20K) AND E2(32K). J Biol Chem 266(8):5104-12
Goebl MG, et al.  (1988) The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme. Science 241(4871):1331-5