MEC1/YBR136W Literature Guide Help

Other names published for MEC1: ESR1, SAD3, RAD31, YBR136W

MEC1 - Regulation of (22)

ReferenceOther Genes Addressed
Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
Pfander B and Diffley JF  (2011) Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment.LID - 10.1038/emboj.2011.345 [doi] EMBO J ()
Puddu F, et al.  (2011) Sensing of Replication Stress and Mec1 Activation Act through Two Independent Pathways Involving the 9-1-1 Complex and DNA Polymerase epsilon. PLoS Genet 7(3):e1002022
Chen SH, et al.  (2010) A proteome-wide analysis of kinase-substrate network in the DNA damage response. J Biol Chem 285(17):12803-12
Donnianni RA, et al.  (2010) Elevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway. PLoS Genet 6(1):e1000763
Rogers C, et al.  (2010) Connecting mutations of the RNA polymerase II C-terminal domain to complex phenotypic changes using combined gene expression and network analyses. PLoS One 5(6):e11386
Barlow JH and Rothstein R  (2009) Rad52 recruitment is DNA replication independent and regulated by Cdc28 and the Mec1 kinase. EMBO J 28(8):1121-30
Molin C, et al.  (2009) mRNA stability changes precede changes in steady-state mRNA amounts during hyperosmotic stress. RNA 15(4):600-14
Kim EM and Burke DJ  (2008) DNA damage activates the SAC in an ATM/ATR-dependent manner, independently of the kinetochore. PLoS Genet 4(2):e1000015
Lazzaro F, et al.  (2008) Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres. EMBO J 27(10):1502-12
Navadgi-Patil VM and Burgers PM  (2008) Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase. J Biol Chem 283(51):35853-9
Guillemain G, et al.  (2007) Mechanisms of checkpoint kinase Rad53 inactivation after a double-strand break in Saccharomyces cerevisiae. Mol Cell Biol 27(9):3378-89
Majka J, et al.  (2006) The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Mol Cell 24(6):891-901
Giannattasio M, et al.  (2005) The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1. J Biol Chem 280(11):9879-86
Giannattasio M, et al.  (2004) Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint. EMBO J 23(2):429-38
Giannattasio M, et al.  (2002) A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1. Proc Natl Acad Sci U S A 99(20):12997-3002
Rouse J and Jackson SP  (2002) Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol Cell 9(4):857-69
Clerici M, et al.  (2001) Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression. EMBO J 20(22):6485-98
Schaus SE, et al.  (2001) Gene transcription analysis of Saccharomyces cerevisiae exposed to neocarzinostatin protein-chromophore complex reveals evidence of DNA damage, a potential mechanism of resistance, and consequences of prolonged exposure. Proc Natl Acad Sci U S A 98(20):11075-80
Holstege FC, et al.  (1998) Dissecting the regulatory circuitry of a eukaryotic genome. Cell 95(5):717-28
Paciotti V, et al.  (1998) Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p. EMBO J 17(14):4199-209
Stuart D and Wittenberg C  (1998) CLB5 and CLB6 are required for premeiotic DNA replication and activation of the meiotic S/M checkpoint. Genes Dev 12(17):2698-710