KEX2/YNL238W Literature Guide Help

Other names published for KEX2: QDS1, VMA45, SRB1, kexin, yscF, YNL238W

KEX2 - Protein/Nucleic Acid Structure (6)

ReferenceOther Genes Addressed
Wheatley JL and Holyoak T  (2007) Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2. Proc Natl Acad Sci U S A 104(16):6626-31
Cai XH, et al.  (2004) Rational redesign of inhibitors of furin/kexin processing proteases by electrostatic mutations. Acta Pharmacol Sin 25(12):1712-818
Holyoak T, et al.  (2004) Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases. Biochemistry 43(9):2412-21
Rockwell NC and Thorner JW  (2004) The kindest cuts of all: crystal structures of Kex2 and furin reveal secrets of precursor processing. Trends Biochem Sci 29(2):80-7
Rozan L, et al.  (2004) Plasticity of extended subsites facilitates divergent substrate recognition by Kex2 and furin. J Biol Chem 279(34):35656-63
Holyoak T, et al.  (2003) 2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor. Biochemistry 42(22):6709-18