MEC1/YBR136W Literature Guide Help

Other names published for MEC1: ESR1, SAD3, RAD31, YBR136W

MEC1 - Protein-protein Interactions (24)

ReferenceOther Genes Addressed
Kubota T, et al.  (2011) Quantitative proteomic analysis of chromatin reveals that Ctf18 acts in the DNA replication checkpoint. Mol Cell Proteomics 10(7):M110.005561
Pfander B and Diffley JF  (2011) Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment.LID - 10.1038/emboj.2011.345 [doi] EMBO J ()
Chen SH, et al.  (2010) A proteome-wide analysis of kinase-substrate network in the DNA damage response. J Biol Chem 285(17):12803-12
McGee JS, et al.  (2010) Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair. Nat Struct Mol Biol 17(12):1438-45
Chen SH and Zhou H  (2009) Reconstitution of Rad53 Activation by Mec1 through Adaptor Protein Mrc1. J Biol Chem 284(28):18593-604
Anderson CM and Blackburn EH  (2008) Mec1 function in the DNA damage response does not require its interaction with Tel2. Cell Cycle 7(23):3695-8
Mordes DA, et al.  (2008) Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A 105(48):18730-4
Liang B, et al.  (2007) RSC functions as an early double-strand-break sensor in the cell's response to DNA damage. Curr Biol 17(16):1432-7
Ma JL, et al.  (2006) Activation of the checkpoint kinase Rad53 by the phosphatidyl inositol kinase-like kinase Mec1. J Biol Chem 281(7):3954-63
Majka J, et al.  (2006) The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Mol Cell 24(6):891-901
Nakada D, et al.  (2005) Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage. Mol Biol Cell 16(11):5227-35
Sweeney FD, et al.  (2005) Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation. Curr Biol 15(15):1364-75
Bartrand AJ, et al.  (2004) DNA stimulates Mec1-mediated phosphorylation of replication protein A. J Biol Chem 279(25):26762-7
Lee SJ, et al.  (2004) A Ddc2-Rad53 fusion protein can bypass the requirements for RAD9 and MRC1 in Rad53 activation. Mol Biol Cell 15(12):5443-55
Kim HS and Brill SJ  (2003) MEC1-dependent phosphorylation of yeast RPA1 in vitro. DNA Repair (Amst) 2(12):1321-35
Lee SJ, et al.  (2003) Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling. Mol Cell Biol 23(17):6300-14
Rouse J and Jackson SP  (2002) Interfaces between the detection, signaling, and repair of DNA damage. Science 297(5581):547-51
Rouse J and Jackson SP  (2002) Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol Cell 9(4):857-69
Clarke DJ, et al.  (2001) Mec1p regulates Pds1p levels in S phase: complex coordination of DNA replication and mitosis. Nat Cell Biol 3(7):619-27
Clerici M, et al.  (2001) Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression. EMBO J 20(22):6485-98
Paciotti V, et al.  (2001) Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway. Mol Cell Biol 21(12):3913-25
Wakayama T, et al.  (2001) Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae. Mol Cell Biol 21(3):755-64
Paciotti V, et al.  (2000) The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes Dev 14(16):2046-59
Rouse J and Jackson SP  (2000) LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae. EMBO J 19(21):5801-12