MCM4/YPR019W Literature Guide Help

Other names published for MCM4: HCD21, CDC54, YPR019W

MCM4 - Protein-protein Interactions (38)

ReferenceOther Genes Addressed
Blitzblau HG, et al.  (2012) Separation of DNA replication from the assembly of break-competent meiotic chromosomes. PLoS Genet 8(5):e1002643
Huo L, et al.  (2012) The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis. Cell Cycle 11(7):1325-39
Wu R, et al.  (2012) Cdt1p, through its interaction with Mcm6p, is required for the formation, nuclear accumulation and chromatin loading of the MCM complex. J Cell Sci 125(Pt 1):209-19
van Deursen F, et al.  (2012) Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation. EMBO J 31(9):2195-206
Bruck I and Kaplan DL  (2011) GINS and Sld3 compete with one another for Mcm2-7 and Cdc45 binding. J Biol Chem 286(16):14157-67
Bruck I and Kaplan DL  (2011) Origin single-stranded DNA releases Sld3 protein from the Mcm2-7 complex, allowing the GINS tetramer to bind the Mcm2-7 complex. J Biol Chem 286(21):18602-13
Bruck I, et al.  (2011) Enabling association of the GINS protein tetramer with the mini chromosome maintenance (Mcm)2-7 protein complex by phosphorylated Sld2 protein and single-stranded origin DNA. J Biol Chem 286(42):36414-26
Kubota T, et al.  (2011) Quantitative proteomic analysis of chromatin reveals that Ctf18 acts in the DNA replication checkpoint. Mol Cell Proteomics 10(7):M110.005561
Takara TJ and Bell SP  (2011) Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases. EMBO J 30(24):4885-96
Han J, et al.  (2010) Ubiquitylation of FACT by the Cullin-E3 ligase Rtt101 connects FACT to DNA replication. Genes Dev 24(14):1485-90
Ma X, et al.  (2010) The effects of oligomerization on Saccharomyces cerevisiae Mcm4/6/7 function. BMC Biochem 11():37
Bruck I and Kaplan D  (2009) Dbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth. J Biol Chem 284(42):28823-31
Evrin C, et al.  (2009) A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication. Proc Natl Acad Sci U S A 106(48):20240-5
Francis LI, et al.  (2009) Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation. Genes Dev 23(5):643-54
Gambus A, et al.  (2009) A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome. EMBO J 28(19):2992-3004
Mimura S, et al.  (2009) SCF(Dia2) regulates DNA replication forks during S-phase in budding yeast. EMBO J 28(23):3693-705
Morohashi H, et al.  (2009) The amino-terminal TPR domain of Dia2 tethers SCF(Dia2) to the replisome progression complex. Curr Biol 19(22):1943-9
Remus D, et al.  (2009) Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell 139(4):719-30
Snyder M, et al.  (2009) The Minichromosome Maintenance Proteins 2-7 (MCM2-7) Are Necessary for RNA Polymerase II (Pol II)-mediated Transcription. J Biol Chem 284(20):13466-72
Stead BE, et al.  (2009) ATP binding and hydrolysis by Mcm2 regulate DNA binding by Mcm complexes. J Mol Biol 391(2):301-13
Bochman ML, et al.  (2008) Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability. Mol Cell Biol 28(19):5865-73
Kanter DM, et al.  (2008) Mcm subunits can assemble into two different active unwinding complexes. J Biol Chem 283(45):31172-82
Bochman ML and Schwacha A  (2007) Differences in the single-stranded DNA binding activities of MCM2-7 and MCM467: MCM2 and MCM5 define a slow ATP-dependent step. J Biol Chem 282(46):33795-804
Gambus A, et al.  (2006) GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol 8(4):358-66
Kanemaki M and Labib K  (2006) Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks. EMBO J 25(8):1753-63
Kawasaki Y, et al.  (2006) Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro. Genes Cells 11(7):745-56
Sheu YJ and Stillman B  (2006) Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression. Mol Cell 24(1):101-13
Biswas-Fiss EE, et al.  (2005) The Mcm467 complex of Saccharomyces cerevisiae is preferentially activated by autonomously replicating DNA sequences. Biochemistry 44(8):2916-25
Mitkova AV, et al.  (2005) Modulation of DNA synthesis in Saccharomyces cerevisiae nuclear extract by DNA polymerases and the origin recognition complex. J Biol Chem 280(8):6285-92
Dasgupta A, et al.  (2004) Sir Antagonist 1 (San1) is a ubiquitin ligase. J Biol Chem 279(26):26830-8