ORC4/YPR162C Literature Guide Help

Other names published for ORC4: origin recognition complex subunit 4, YPR162C

ORC4 - Protein-Nucleic Acid Interactions (27)

ReferenceOther Genes Addressed
Sun J, et al.  (2012) Cdc6-Induced Conformational Changes in ORC Bound to Origin DNA Revealed by Cryo-Electron Microscopy. Structure 20(3):534-44
Zhang X, et al.  (2012) Functions of Protosilencers in the Formation and Maintenance of Heterochromatin in Saccharomyces cerevisiae. PLoS One 7(5):e37092
Chang F, et al.  (2011) High-resolution analysis of four efficient yeast replication origins reveals new insights into the ORC and putative MCM binding elements. Nucleic Acids Res 39(15):6523-35
Takara TJ and Bell SP  (2011) Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases. EMBO J 30(24):4885-96
Ozaydin B and Rine J  (2010) Expanded Roles of the Origin Recognition Complex in the Architecture and Function of Silenced Chromatin in Saccharomyces cerevisiae. Mol Cell Biol 30(3):626-39
Tsakraklides V and Bell SP  (2010) Dynamics of pre-replicative complex assembly. J Biol Chem 285(13):9437-43
Francis LI, et al.  (2009) Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation. Genes Dev 23(5):643-54
Remus D, et al.  (2009) Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell 139(4):719-30
Shor E, et al.  (2009) The origin recognition complex interacts with a subset of metabolic genes tightly linked to origins of replication. PLoS Genet 5(12):e1000755
Chen Z, et al.  (2008) The architecture of the DNA replication origin recognition complex in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 105(30):10326-31
Asano T, et al.  (2007) Interaction between ORC and Cdt1p of Saccharomyces cerevisiae. FEMS Yeast Res 7(8):1256-62
Speck C and Stillman B  (2007) Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication. J Biol Chem 282(16):11705-14
Kawasaki Y, et al.  (2006) Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro. Genes Cells 11(7):745-56
Randell JC, et al.  (2006) Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase. Mol Cell 21(1):29-39
Xu W, et al.  (2006) Genome-wide mapping of ORC and Mcm2p binding sites on tiling arrays and identification of essential ARS consensus sequences in S. cerevisiae. BMC Genomics 7():276
Biswas SB, et al.  (2005) Control of ATP-dependent binding of Saccharomyces cerevisiae origin recognition complex to autonomously replicating DNA sequences. Cell Cycle 4(3):494-500
Speck C, et al.  (2005) ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA. Nat Struct Mol Biol 12(11):965-71
Chastain PD 2nd, et al.  (2004) Mapping subunit location on the Saccharomyces cerevisiae origin recognition complex free and bound to DNA using a novel nanoscale biopointer. J Biol Chem 279(35):36354-62
Palacios DeBeer MA, et al.  (2003) Differential DNA affinity specifies roles for the origin recognition complex in budding yeast heterochromatin. Genes Dev 17(15):1817-22
Giraldo R and Diaz-Orejas R  (2001) Similarities between the DNA replication initiators of Gram-negative bacteria plasmids (RepA) and eukaryotes (Orc4p)/archaea (Cdc6p). Proc Natl Acad Sci U S A 98(9):4938-43
Lipford JR and Bell SP  (2001) Nucleosomes positioned by ORC facilitate the initiation of DNA replication. Mol Cell 7(1):21-30
Mizushima T, et al.  (2000) Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro. Genes Dev 14(13):1631-41
Lee DG and Bell SP  (1997) Architecture of the yeast origin recognition complex bound to origins of DNA replication. Mol Cell Biol 17(12):7159-68
Liang C and Stillman B  (1997) Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants. Genes Dev 11(24):3375-86
Santocanale C and Diffley JF  (1996) ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae. EMBO J 15(23):6671-9
Rowley A, et al.  (1995) Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC. EMBO J 14(11):2631-41
Diffley JF, et al.  (1994) Two steps in the assembly of complexes at yeast replication origins in vivo. Cell 78(2):303-16