RAD53/YPL153C Literature Guide Help

Other names published for RAD53: LSD1, MEC2, SPK1, YPL153C

RAD53 - Protein Sequence Features (47)

ReferenceOther Genes Addressed
Jiao Y, et al.  (2012) Surprising complexity of the Asf1 histone chaperone-Rad53 kinase interaction. Proc Natl Acad Sci U S A 109(8):2866-71
Manfrini N, et al.  (2012) G(1)/S and G(2)/M cyclin-dependent kinase activities commit cells to death in the absence of the S-phase checkpoint. Mol Cell Biol 32(24):4971-85
Pershad K, et al.  (2012) Directed evolution of the forkhead-associated domain to generate anti-phosphospecific reagents by phage display. J Mol Biol 424(1-2):88-103
Aucher W, et al.  (2010) A Strategy for Interaction Site Prediction between Phospho-binding Modules and their Partners Identified from Proteomic Data. Mol Cell Proteomics 9(12):2745-59
Granata M, et al.  (2010) Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity.LID - e1001047 [pii] PLoS Genet 6(8)
Matsumura Y, et al.  (2010) alpha-Helical burst on the folding pathway of FHA domains from Rad53 and Ki67. Biochimie 92(8):1031-9
Schleker T, et al.  (2010) Cell cycle-dependent phosphorylation of Rad53 kinase by Cdc5 and Cdc28 modulates checkpoint adaptation. Cell Cycle 9(2):350-63
Vidanes GM, et al.  (2010) CDC5 Inhibits the Hyperphosphorylation of the Checkpoint Kinase Rad53, Leading to Checkpoint Adaptation. PLoS Biol 8(1):e1000286
Chen SH and Zhou H  (2009) Reconstitution of Rad53 Activation by Mec1 through Adaptor Protein Mrc1. J Biol Chem 284(28):18593-604
Diani L, et al.  (2009) Saccharomyces CDK1 Phosphorylates Rad53 Kinase in Metaphase, Influencing Cellular Morphogenesis. J Biol Chem 284(47):32627-34
Feng W, et al.  (2009) Centromere replication timing determines different forms of genomic instability in Saccharomyces cerevisiae checkpoint mutants during replication stress. Genetics 183(4):1249-60
Ohuchi T, et al.  (2009) Accumulation of sumoylated Rad52 in checkpoint mutants perturbed in DNA replication. DNA Repair (Amst) 8(6):690-6
Fiorani S, et al.  (2008) Characterization of the activation domain of the Rad53 checkpoint kinase. Cell Cycle 7(4):493-9
Jia-Lin Ma N and Stern DF  (2008) Regulation of the Rad53 protein kinase in signal amplification by oligomer assembly and disassembly. Cell Cycle 7(6):808-17
Lee H, et al.  (2008) Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade. Mol Cell 30(6):767-78
Szyjka SJ, et al.  (2008) Rad53 regulates replication fork restart after DNA damage in Saccharomyces cerevisiae. Genes Dev 22(14):1906-20
Tam AT, et al.  (2008) Location-specific functions of the two forkhead-associated domains in rad53 checkpoint kinase signaling. Biochemistry 47(12):3912-6
Chen SH, et al.  (2007) Mechanism of Dun1 activation by Rad53 phosphorylation in Saccharomyces cerevisiae. J Biol Chem 282(2):986-95
Guillemain G, et al.  (2007) Mechanisms of checkpoint kinase Rad53 inactivation after a double-strand break in Saccharomyces cerevisiae. Mol Cell Biol 27(9):3378-89
Dohrmann PR and Sclafani RA  (2006) Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae. Genetics 174(1):87-99
Smolka MB, et al.  (2006) An FHA domain-mediated protein interaction network of Rad53 reveals its role in polarized cell growth. J Cell Biol 175(5):743-53
Smolka MB, et al.  (2005) Dynamic changes in protein-protein interaction and protein phosphorylation probed with amine-reactive isotope tag. Mol Cell Proteomics 4(9):1358-69
Sweeney FD, et al.  (2005) Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation. Curr Biol 15(15):1364-75
Pike BL, et al.  (2004) Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae. Mol Cell Biol 24(7):2779-88
Pike BL, et al.  (2004) Rad53 kinase activation-independent replication checkpoint function of the N-terminal forkhead-associated (FHA1) domain. J Biol Chem 279(38):39636-44
Yongkiettrakul S, et al.  (2004) The ligand specificity of yeast Rad53 FHA domains at the +3 position is determined by nonconserved residues. Biochemistry 43(13):3862-9
Leroy C, et al.  (2003) PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break. Mol Cell 11(3):827-35
Pike BL, et al.  (2003) Diverse but overlapping functions of the two forkhead-associated (FHA) domains in Rad53 checkpoint kinase activation. J Biol Chem 278(33):30421-4
Schwartz MF, et al.  (2003) FHA domain-mediated DNA checkpoint regulation of Rad53. Cell Cycle 2(4):384-96
Scott KL and Plon SE  (2003) Loss of Sin3/Rpd3 histone deacetylase restores the DNA damage response in checkpoint-deficient strains of Saccharomyces cerevisiae. Mol Cell Biol 23(13):4522-31