GCN2/YDR283C Literature Guide Help

Other names published for GCN2: AAS1, NDR2, AAS102, YDR283C

GCN2 - Protein Sequence Features (31)

Results: 1 - 30 of 31 records
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ReferenceOther Genes Addressed
Kimpe M, et al.  (2012) Pkh1 interacts with and phosphorylates components of the yeast Gcn2/eIF2a system. Biochem Biophys Res Commun 419(1):89-94
Uluisik I, et al.  (2011) Boron stress activates the general amino acid control mechanism and inhibits protein synthesis. PLoS One 6(11):e27772
Visweswaraiah J, et al.  (2011) Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity. J Biol Chem 286(42):36568-79
Cherkasova V, et al.  (2010) Snf1 promotes phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4. Mol Cell Biol 30(12):2862-73
Gallego O, et al.  (2010) A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. Mol Syst Biol 6():430
Moravcevic K, et al.  (2010) Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids. Cell 143(6):966-77
Nomura W, et al.  (2010) Methylglyoxal activates Gcn2 to phosphorylate eIF2alpha independently of the TOR pathway in Saccharomyces cerevisiae. Appl Microbiol Biotechnol 86(6):1887-94
Soulard A, et al.  (2010) The Rapamycin-sensitive Phosphoproteome Reveals That TOR Controls Protein Kinase A Toward Some But Not All Substrates. Mol Biol Cell 21(19):3475-86
Garriz A, et al.  (2009) A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2. Mol Cell Biol 29(6):1592-607
Wout PK, et al.  (2009) Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2 interact on Polyribosomes with Gcn1. Eukaryot Cell 8(7):1061-71
Menacho-Marquez M, et al.  (2007) Gcn2p regulates a G1/S cell cycle checkpoint in response to DNA damage. Cell Cycle 6(18):2302-5
Padyana AK, et al.  (2005) Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2. J Biol Chem 280(32):29289-99
Narasimhan J, et al.  (2004) Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions. J Biol Chem 279(22):22820-32
Cherkasova VA and Hinnebusch AG  (2003) Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2. Genes Dev 17(7):859-72
Garcia-Barrio M, et al.  (2002) Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2. J Biol Chem 277(34):30675-83
Dong J, et al.  (2000) Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain. Mol Cell 6(2):269-79
Kubota H, et al.  (2000) GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast. J Biol Chem 275(27):20243-6
Yang R, et al.  (2000) Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase. Mol Cell Biol 20(8):2706-17
Young ET, et al.  (2000) Trinucleotide repeats are clustered in regulatory genes in Saccharomyces cerevisiae. Genetics 154(3):1053-68
Qiu H, et al.  (1998) Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain. Mol Cell Biol 18(5):2697-711
Romano PR, et al.  (1998) Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2. Mol Cell Biol 18(4):2282-97
Zhu S and Wek RC  (1998) Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control. J Biol Chem 273(3):1808-14
Zhu S, et al.  (1996) Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2. J Biol Chem 271(40):24989-94
Diallinas G and Thireos G  (1994) Genetic and biochemical evidence for yeast GCN2 protein kinase polymerization. Gene 143(1):21-7
Vazquez de Aldana CR, et al.  (1993) Mutations in the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha) that overcome the inhibitory effect of eIF-2 alpha phosphorylation on translation initiation. Proc Natl Acad Sci U S A 90(15):7215-9
Ramirez M, et al.  (1992) Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases. Mol Cell Biol 12(12):5801-15
Ramirez M, et al.  (1991) Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae. Mol Cell Biol 11(6):3027-36
Hannig EM, et al.  (1990) The translational activator GCN3 functions downstream from GCN1 and GCN2 in the regulatory pathway that couples GCN4 expression to amino acid availability in Saccharomyces cerevisiae. Genetics 126(3):549-62
Wek RC, et al.  (1990) Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression. Mol Cell Biol 10(6):2820-31
Wek RC, et al.  (1989) Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability. Proc Natl Acad Sci U S A 86(12):4579-83
Results: 1 - 30 of 31 records
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