KEX2/YNL238W Literature Guide Help

Other names published for KEX2: QDS1, VMA45, SRB1, kexin, yscF, YNL238W

KEX2 - Protein Sequence Features (24)

ReferenceOther Genes Addressed
Abazeed ME and Fuller RS  (2008) Yeast golgi-localized, gamma-Ear-containing, ADP-ribosylation factor-binding proteins are but adaptor protein-1 is not required for cell-free transport of membrane proteins from the trans-golgi network to the prevacuolar compartment. Mol Biol Cell 19(11):4826-36
Wheatley JL and Holyoak T  (2007) Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2. Proc Natl Acad Sci U S A 104(16):6626-31
Abazeed ME, et al.  (2005) Cell-free transport from the trans-golgi network to late endosome requires factors involved in formation and consumption of clathrin-coated vesicles. J Biol Chem 280(6):4442-50
Han HE, et al.  (2005) Engineering of Kex2 variants exhibiting altered substrate specificity. Biochem Biophys Res Commun 337(4):1102-6
Johnston HD, et al.  (2005) Golgi-to-late endosome trafficking of the yeast pheromone processing enzyme Ste13p is regulated by a phosphorylation site in its cytosolic domain. Mol Biol Cell 16(3):1456-68
Blanchette JM, et al.  (2004) Cell-free reconstitution of transport from the trans-golgi network to the late endosome/prevacuolar compartment. J Biol Chem 279(47):48767-73
Ringe D, et al.  (2004) Protein structure to function: insights from computation. Cell Mol Life Sci 61(4):387-92
Sipos G, et al.  (2004) Soi3p/Rav1p functions at the early endosome to regulate endocytic trafficking to the vacuole and localization of trans-Golgi network transmembrane proteins. Mol Biol Cell 15(7):3196-209
Lesage G, et al.  (2003) trans-Complementation assay establishes the role of proregion hydrophobic amino acid residues in the biosynthesis of Saccharomyces cerevisiae Kex2p endoprotease. Yeast 20(5):397-406
Rockwell NC and Fuller RS  (2001) Direct measurement of acylenzyme hydrolysis demonstrates rate-limiting deacylation in cleavage of physiological sequences by the processing protease Kex2. Biochemistry 40(12):3657-65
Lesage G, et al.  (2000) The Kex2p proregion is essential for the biosynthesis of an active enzyme and requires a C-terminal basic residue for its function. Mol Biol Cell 11(6):1947-57
Suzuki Y, et al.  (2000) Effect of amino acid substitution at the P(3) and P(4) subsites of fusion proteins on kex2 protease activity. Biotechnol Appl Biochem 32 ( Pt 1):53-60
Bevan A, et al.  (1998) Quantitative assessment of enzyme specificity in vivo: P2 recognition by Kex2 protease defined in a genetic system. Proc Natl Acad Sci U S A 95(18):10384-9
Brickner JH and Fuller RS  (1997) SOI1 encodes a novel, conserved protein that promotes TGN-endosomal cycling of Kex2p and other membrane proteins by modulating the function of two TGN localization signals. J Cell Biol 139(1):23-36
Redding K, et al.  (1996) Allele-specific suppression of a defective trans-Golgi network (TGN) localization signal in Kex2p identifies three genes involved in localization of TGN transmembrane proteins. Mol Cell Biol 16(11):6208-17
Tan PK, et al.  (1996) The sequence NPFXD defines a new class of endocytosis signal in Saccharomyces cerevisiae. J Cell Biol 135(6 Pt 2):1789-800
Gluschankof P and Fuller RS  (1994) A C-terminal domain conserved in precursor processing proteases is required for intramolecular N-terminal maturation of pro-Kex2 protease. EMBO J 13(10):2280-8
Germain D, et al.  (1993) Processing of Kex2 pro-region at two interchangeable cleavage sites. FEBS Lett 323(1-2):129-31
Brenner C and Fuller RS  (1992) Structural and enzymatic characterization of a purified prohormone-processing enzyme: secreted, soluble Kex2 protease. Proc Natl Acad Sci U S A 89(3):922-6
Germain D, et al.  (1992) Expression of the Saccharomyces cerevisiae Kex2p endoprotease in inset cells. Evidence for a carboxy-terminal autoprocessing event. Eur J Biochem 204(1):121-6
Germain D, et al.  (1992) The pro-region of the Kex2 endoprotease of Saccharomyces cerevisiae is removed by self-processing. FEBS Lett 299(3):283-6
Wilcox CA, et al.  (1992) Mutation of a tyrosine localization signal in the cytosolic tail of yeast Kex2 protease disrupts Golgi retention and results in default transport to the vacuole. Mol Biol Cell 3(12):1353-71
Fuller RS, et al.  (1989) Intracellular targeting and structural conservation of a prohormone-processing endoprotease. Science 246(4929):482-6
Mizuno K, et al.  (1988) Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases. Biochem Biophys Res Commun 156(1):246-54