TOP2/YNL088W Literature Guide Help

Other names published for TOP2: TOR3, TRF3, DNA topoisomerase 2, YNL088W

TOP2 - Protein Sequence Features (27)

ReferenceOther Genes Addressed
Schmidt BH, et al.  (2012) Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity. Nat Struct Mol Biol 19(11):1147-54
Schmidt BH, et al.  (2010) A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature 465(7298):641-4
Rogojina AT and Nitiss JL  (2008) Isolation and Characterization of mAMSA-hypersensitive Mutants: CYTOTOXICITY OF Top2 COVALENT COMPLEXES CONTAINING DNA SINGLE STRAND BREAKS. J Biol Chem 283(43):29239-50
Dong KC and Berger JM  (2007) Structural basis for gate-DNA recognition and bending by type IIA topoisomerases. Nature 450(7173):1201-5
Barker CR, et al.  (2006) The identification and characterisation of a functional interaction between arginyl-tRNA-protein transferase and topoisomerase II. Biochem Biophys Res Commun 342(2):596-604
Mouchel NA and Jenkins JR  (2006) The identification of a functional interaction between PKC and topoisomerase II. FEBS Lett 580(1):51-7
Jiang X  (2005) Random mutagenesis of the B'A' core domain of yeast DNA topoisomerase II and large-scale screens of mutants resistant to the anticancer drug etoposide. Biochem Biophys Res Commun 327(2):597-603
Vaughn J, et al.  (2005) Stability of the topoisomerase II closed clamp conformation may influence DNA-stimulated ATP hydrolysis. J Biol Chem 280(12):11920-9
Moro S, et al.  (2004) Interaction model for anthracycline activity against DNA topoisomerase II. Biochemistry 43(23):7503-13
Classen S, et al.  (2003) Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc Natl Acad Sci U S A 100(19):10629-34
Strumberg D, et al.  (2002) Importance of the fourth alpha-helix within the CAP homology domain of type II topoisomerase for DNA cleavage site recognition and quinolone action. Antimicrob Agents Chemother 46(9):2735-46
Mizushina Y, et al.  (2000) Structural homology between DNA binding sites of DNA polymerase beta and DNA topoisomerase II. J Mol Biol 304(3):385-95
Kim KH, et al.  (1999) Cloning and characterization of the gene encoding Aspergillus nidulans DNA topoisomerase II. Gene 236(2):293-301
Liu Q and Wang JC  (1999) Similarity in the catalysis of DNA breakage and rejoining by type IA and IIA DNA topoisomerases. Proc Natl Acad Sci U S A 96(3):881-6
Olland S and Wang JC  (1999) Catalysis of ATP hydrolysis by two NH(2)-terminal fragments of yeast DNA topoisomerase II. J Biol Chem 274(31):21688-94
Strumberg D, et al.  (1999) Molecular analysis of yeast and human type II topoisomerases. Enzyme-DNA and drug interactions. J Biol Chem 274(40):28246-55
Wessel I, et al.  (1999) Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform. Cancer Res 59(14):3442-50
Liu Q and Wang JC  (1998) Identification of active site residues in the "GyrA" half of yeast DNA topoisomerase II. J Biol Chem 273(32):20252-60
Benedetti P, et al.  (1997) Study of yeast DNA topoisomerase II and its truncation derivatives by transmission electron microscopy. J Biol Chem 272(18):12132-7
Patel S, et al.  (1997) Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cytotoxicity. Mol Pharmacol 52(4):658-66
Hung F, et al.  (1996) Characterization of topoisomerase II-DNA interaction and identification of a DNA-binding domain by ultraviolet laser crosslinking. FEBS Lett 380(1-2):127-32
Jensen S, et al.  (1996) Analysis of functional domain organization in DNA topoisomerase II from humans and Saccharomyces cerevisiae. Mol Cell Biol 16(7):3866-77
Roca J, et al.  (1996) DNA transport by a type II topoisomerase: direct evidence for a two-gate mechanism. Proc Natl Acad Sci U S A 93(9):4057-62
Froelich-Ammon SJ, et al.  (1995) Increased drug affinity as the mechanistic basis for drug hypersensitivity of a mutant type II topoisomerase. J Biol Chem 270(47):28018-21
Vassetzky YS, et al.  (1994) Topoisomerase II forms multimers in vitro: effects of metals, beta-glycerophosphate, and phosphorylation of its C-terminal domain. Mol Cell Biol 14(10):6962-74
Cardenas ME, et al.  (1992) Casein kinase II phosphorylates the eukaryote-specific C-terminal domain of topoisomerase II in vivo. EMBO J 11(5):1785-96
Roca J and Wang JC  (1992) The capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerases. Cell 71(5):833-40