HMG2/YLR450W Literature Guide Help

Other names published for HMG2: hydroxymethylglutaryl-CoA reductase (NADPH) HMG2, YLR450W

HMG2 - Protein Sequence Features (12)

ReferenceOther Genes Addressed
Breidenbach MA, et al.  (2012) Mapping yeast N-glycosites with isotopically recoded glycans. Mol Cell Proteomics 11(6):M111.015339
Ma SM, et al.  (2011) Optimization of a heterologous mevalonate pathway through the use of variant HMG-CoA reductases. Metab Eng 13(5):588-97
Theesfeld CL, et al.  (2011) The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2. J Biol Chem 286(30):26298-307
Mantzouridou F and Tsimidou MZ  (2010) Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6. FEMS Yeast Res 10(6):699-707
Garza RM, et al.  (2009) Geranylgeranyl Pyrophosphate Is a Potent Regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA Reductase Degradation in Yeast. J Biol Chem 284(51):35368-80
Garza RM, et al.  (2009) In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase. J Biol Chem 284(22):14710-22
Federovitch CM, et al.  (2008) Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae. Mol Biol Cell 19(10):4506-20
Shearer AG and Hampton RY  (2005) Lipid-mediated, reversible misfolding of a sterol-sensing domain protein. EMBO J 24(1):149-59
Profant DA, et al.  (2000) Mutational analysis of the karmellae-inducing signal in Hmg1p, a yeast HMG-CoA reductase isozyme. Yeast 16(9):811-27
Gardner RG and Hampton RY  (1999) A 'distributed degron' allows regulated entry into the ER degradation pathway. EMBO J 18(21):5994-6004
Gardner R, et al.  (1998) Sequence determinants for regulated degradation of yeast 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell 9(9):2611-26
Parrish ML, et al.  (1995) Identification of the sequences in HMG-CoA reductase required for karmellae assembly. Mol Biol Cell 6(11):1535-47