CYS4/YGR155W Literature Guide Help

Other names published for CYS4: NHS5, STR4, VMA41, cystathionine beta-synthase CYS4, YGR155W

CYS4 - Primary Literature (42)

ReferenceOther Genes Addressed
Harsch MJ and Gardner RC  (2013) Yeast genes involved in sulfur and nitrogen metabolism affect the production of volatile thiols from Sauvignon Blanc musts. Appl Microbiol Biotechnol 97(1):223-35
Hoose SA, et al.  (2012) A systematic analysis of cell cycle regulators in yeast reveals that most factors act independently of cell size to control initiation of division. PLoS Genet 8(3):e1002590
Mayfield JA, et al.  (2012) Surrogate genetics and metabolic profiling for characterization of human disease alleles. Genetics 190(4):1309-23
Orumets K, et al.  (2012) YAP1 over-expression in Saccharomyces cerevisiae enhances glutathione accumulation at its biosynthesis and substrate availability levels. Biotechnol J 7(4):566-8
Kumar A, et al.  (2011) Converging evidence of mitochondrial dysfunction in a yeast model of homocysteine metabolism imbalance. J Biol Chem 286(24):21779-95
Singh S, et al.  (2011) Pre-steady-state kinetic analysis of enzyme-monitored turnover during cystathionine ?-synthase-catalyzed H(2)S generation. Biochemistry 50(3):419-25
Suzuki T, et al.  (2011) Identification and characterization of genes involved in glutathione production in yeast. J Biosci Bioeng 112(2):107-13
Yoshida S, et al.  (2011) A novel mechanism regulates H(2) S and SO(2) production in Saccharomyces cerevisiae. Yeast 28(2):109-21
Lodha PH, et al.  (2010) Residue N84 of Yeast Cystathionine beta-Synthase is a Determinant of Reaction Specificity. Biochim Biophys Acta 1804(7):1424-1431
Blank HM, et al.  (2009) Sulfur metabolism actively promotes initiation of cell division in yeast. PLoS One 4(11):e8018
Kim HS and Fay JC  (2009) A Combined-Cross Analysis Reveals Genes With Drug-Specific and Background-Dependent Effects on Drug Sensitivity in Saccharomyces cerevisiae. Genetics 183(3):1141-51
Kim HS, et al.  (2009) Dissecting the pleiotropic consequences of a quantitative trait nucleotide. FEMS Yeast Res 9(5):713-22
Lodha PH, et al.  (2009) Investigation of residues Lys112, Glu136, His138, Gly247, Tyr248, and Asp249 in the active site of yeast cystathionine beta-synthase. Biochem Cell Biol 87(3):531-40
Quazi F and Aitken SM  (2009) Characterization of the S289A,D mutants of yeast cystathionine beta-synthase. Biochim Biophys Acta 1794(6):892-7
Singh LR and Kruger WD  (2009) Functional Rescue of Mutant Human Cystathionine {beta}-Synthase by Manipulation of Hsp26 and Hsp70 Levels in Saccharomyces cerevisiae. J Biol Chem 284(7):4238-45
Singh S, et al.  (2009) Relative Contributions of Cystathionine {beta}-Synthase and {gamma}-Cystathionase to H2S Biogenesis via Alternative Trans-sulfuration Reactions. J Biol Chem 284(33):22457-66
Linderholm AL, et al.  (2008) Identification of genes affecting hydrogen sulfide formation in Saccharomyces cerevisiae. Appl Environ Microbiol 74(5):1418-27
Ruotolo R, et al.  (2008) Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast. Genome Biol 9(4):R67
Kim HS and Fay JC  (2007) Genetic variation in the cysteine biosynthesis pathway causes sensitivity to pharmacological compounds. Proc Natl Acad Sci U S A 104(49):19387-91
Menant A, et al.  (2006) Determinants of the ubiquitin-mediated degradation of the Met4 transcription factor. J Biol Chem 281(17):11744-54
Srikanth CV, et al.  (2005) Multiple cis-regulatory elements and the yeast sulphur regulatory network are required for the regulation of the yeast glutathione transporter, Hgt1p. Curr Genet 47(6):345-58
Aitken SM and Kirsch JF  (2004) Role of active-site residues Thr81, Ser82, Thr85, Gln157, and Tyr158 in yeast cystathionine beta-synthase catalysis and reaction specificity. Biochemistry 43(7):1963-71
Aitken SM and Kirsch JF  (2003) Kinetics of the yeast cystathionine beta-synthase forward and reverse reactions: continuous assays and the equilibrium constant for the reaction. Biochemistry 42(2):571-8
Taoka S and Banerjee R  (2002) Stopped-flow kinetic analysis of the reaction catalyzed by the full-length yeast cystathionine beta-synthase. J Biol Chem 277(25):22421-5
Kabil O, et al.  (2001) Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine beta-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme. J Biol Chem 276(22):19350-5
Brenner C  (2000) A cultivated taste for yeast. Genome Biol 1(1):REVIEWS103
Hansen J and Johannesen PF  (2000) Cysteine is essential for transcriptional regulation of the sulfur assimilation genes in Saccharomyces cerevisiae. Mol Gen Genet 263(3):535-42
Jhee KH, et al.  (2000) Domain architecture of the heme-independent yeast cystathionine beta-synthase provides insights into mechanisms of catalysis and regulation. Biochemistry 39(34):10548-56
Jhee KH, et al.  (2000) Yeast cystathionine beta-synthase is a pyridoxal phosphate enzyme but, unlike the human enzyme, is not a heme protein. J Biol Chem 275(16):11541-4
Maclean KN, et al.  (2000) Transsulfuration in Saccharomyces cerevisiae is not dependent on heme: purification and characterization of recombinant yeast cystathionine beta-synthase. J Inorg Biochem 81(3):161-71