ERG9/YHR190W Literature Guide Help

Other names published for ERG9: bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase, YHR190W

ERG9 - Primary Literature (23)

ReferenceOther Genes Addressed
Scalcinati G, et al.  (2012) Dynamic control of gene expression in Saccharomyces cerevisiae engineered for the production of plant sesquitepene a-santalene in a fed-batch mode. Metab Eng 14(2):91-103
Ta TM, et al.  (2012) Accumulation of squalene is associated with the clustering of lipid droplets. FEBS J 279(22):4231-44
Madsen KM, et al.  (2011) Linking Genotype and Phenotype of Saccharomyces cerevisiae Strains Reveals Metabolic Engineering Targets and Leads to Triterpene Hyper-Producers. PLoS One 6(3):e14763
Asadollahi MA, et al.  (2010) Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae. Biotechnol Bioeng 106(1):86-96
Muramatsu M, et al.  (2009) Alkaline pH enhances farnesol production by Saccharomyces cerevisiae. J Biosci Bioeng 108(1):52-5
Muramatsu M, et al.  (2008) Accumulation of prenyl alcohols by terpenoid biosynthesis inhibitors in various microorganisms. Appl Microbiol Biotechnol 80(4):589-95
Paradise EM, et al.  (2008) Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase. Biotechnol Bioeng 100(2):371-8
Buurman ET, et al.  (2005) Utilization of target-specific, hypersensitive strains of Saccharomyces cerevisiae to determine the mode of action of antifungal compounds. Antimicrob Agents Chemother 49(6):2558-60
Hongay C, et al.  (2002) Mot3 is a transcriptional repressor of ergosterol biosynthetic genes and is required for normal vacuolar function in Saccharomyces cerevisiae. EMBO J 21(15):4114-24
Kennedy MA and Bard M  (2001) Positive and negative regulation of squalene synthase (ERG9), an ergosterol biosynthetic gene, in Saccharomyces cerevisiae. Biochim Biophys Acta 1517(2):177-89
Merkulov S, et al.  (2000) Cloning and characterization of the Yarrowia lipolytica squalene synthase (SQS1) gene and functional complementation of the Saccharomyces cerevisiae erg9 mutation. Yeast 16(3):197-206
Radisky ES and Poulter CD  (2000) Squalene synthase: steady-state, pre-steady-state, and isotope-trapping studies. Biochemistry 39(7):1748-60
Kalinowski SS and Mookhtiar KA  (1999) Mechanism of inhibition of yeast squalene synthase by substrate analog inhibitors. Arch Biochem Biophys 368(2):338-46
Hanley KM, et al.  (1996) Molecular cloning, in vitro expression and characterization of a plant squalene synthetase cDNA. Plant Mol Biol 30(6):1139-51
Mookhtiar KA, et al.  (1994) Yeast squalene synthase. A mechanism for addition of substrates and activation by NADPH. J Biol Chem 269(15):11201-7
Zhang D, et al.  (1993) Yeast squalene synthase: expression, purification, and characterization of soluble recombinant enzyme. Arch Biochem Biophys 304(1):133-43
Fegueur M, et al.  (1991) Isolation and primary structure of the ERG9 gene of Saccharomyces cerevisiae encoding squalene synthetase. Curr Genet 20(5):365-72
Jennings SM, et al.  (1991) Molecular cloning and characterization of the yeast gene for squalene synthetase. Proc Natl Acad Sci U S A 88(14):6038-42
Hata S, et al.  (1982) Effect of detergents on sterol synthesis in a cell-free system of yeast. J Lipid Res 23(6):803-10
Agnew WS and Popjak G  (1978) Squalene synthetase. Solubilization from yeast microsomes of a phospholipid-requiring enzyme. J Biol Chem 253(13):4574-83
Agnew WS and Popjak G  (1978) Squalene synthetase. Stoichiometry and kinetics of presqualene pyrophosphate and squalene synthesis by yeast microsomes. J Biol Chem 253(13):4566-73
Karst F and Lacroute F  (1977) Ertosterol biosynthesis in Saccharomyces cerevisiae: mutants deficient in the early steps of the pathway. Mol Gen Genet 154(3):269-77
Ortiz de Montellano PR, et al.  (1977) Substrate selectivity of squalene synthetase. Biochemistry 16(12):2680-5