KEX2/YNL238W Literature Guide Help

Other names published for KEX2: QDS1, VMA45, SRB1, kexin, yscF, YNL238W

KEX2 - Non-Fungal Related Genes/Proteins (34)

ReferenceOther Genes Addressed
Seidah NG and Prat A  (2012) The biology and therapeutic targeting of the proprotein convertases. Nat Rev Drug Discov 11(5):367-83
Seidah NG, et al.  (2006) The proprotein convertases and their implication in sterol and/or lipid metabolism. Biol Chem 387(7):871-7
Bassi DE, et al.  (2005) Proprotein convertases: "master switches" in the regulation of tumor growth and progression. Mol Carcinog 44(3):151-61
Henrich S, et al.  (2005) Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity. J Mol Biol 345(2):211-27
Beatson S and Ponting CP  (2004) GIFT domains: linking eukaryotic intraflagellar transport and glycosylation to bacterial gliding. Trends Biochem Sci 29(8):396-9
Cai XH, et al.  (2004) Rational redesign of inhibitors of furin/kexin processing proteases by electrostatic mutations. Acta Pharmacol Sin 25(12):1712-818
Holyoak T, et al.  (2004) Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases. Biochemistry 43(9):2412-21
Liu ZX, et al.  (2004) Two engineered eglin c mutants potently and selectively inhibiting kexin or furin. FEBS Lett 556(1-3):116-20
Podsiadlo P, et al.  (2004) Furin inhibition by compounds of copper and zinc. J Biol Chem 279(35):36219-27
Ringe D, et al.  (2004) Protein structure to function: insights from computation. Cell Mol Life Sci 61(4):387-92
Rockwell NC and Thorner JW  (2004) The kindest cuts of all: crystal structures of Kex2 and furin reveal secrets of precursor processing. Trends Biochem Sci 29(2):80-7
Rockwell NC and Fuller RS  (2002) Specific modulation of Kex2/furin family proteases by potassium. J Biol Chem 277(20):17531-7
Moulard M and Decroly E  (2000) Maturation of HIV envelope glycoprotein precursors by cellular endoproteases. Biochim Biophys Acta 1469(3):121-32
Poggeler S  (2000) Two pheromone precursor genes are transcriptionally expressed in the homothallic ascomycete Sordaria macrospora. Curr Genet 37(6):403-11
Zhong M, et al.  (1999) The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity. J Biol Chem 274(48):33913-20
Zhou A, et al.  (1999) Proteolytic processing in the secretory pathway. J Biol Chem 274(30):20745-8
Gomez-Saladin E, et al.  (1997) Isolation of a cDNA encoding a Kex2-like endoprotease with homology to furin from the nematode Caenorhabditis elegans. DNA Cell Biol 16(5):663-9
Denault JB and Leduc R  (1996) Furin/PACE/SPC1: a convertase involved in exocytic and endocytic processing of precursor proteins. FEBS Lett 379(2):113-6
Kayo T, et al.  (1996) Developmental expression of proprotein-processing endoprotease furin in rat pancreatic islets. Endocrinology 137(11):5126-34
Seidah NG, et al.  (1996) cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases. Proc Natl Acad Sci U S A 93(8):3388-93
Thacker C, et al.  (1995) The bli-4 locus of Caenorhabditis elegans encodes structurally distinct kex2/subtilisin-like endoproteases essential for early development and adult morphology. Genes Dev 9(8):956-71
Enderlin CS and Ogrydziak DM  (1994) Cloning, nucleotide sequence and functions of XPR6, which codes for a dibasic processing endoprotease from the yeast Yarrowia lipolytica. Yeast 10(1):67-79
Suzuki C and Nikkuni S  (1994) The primary and subunit structure of a novel type killer toxin produced by a halotolerant yeast, Pichia farinosa. J Biol Chem 269(4):3041-6
Nakayama K, et al.  (1992) Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression. J Biol Chem 267(9):5897-900
Oda K, et al.  (1992) Proteolytic cleavages of proalbumin and complement Pro-C3 in vitro by a truncated soluble form of furin, a mammalian homologue of the yeast Kex2 protease. Biochem Biophys Res Commun 189(3):1353-61
Roebroek AJ, et al.  (1992) Cloning and functional expression of Dfurin2, a subtilisin-like proprotein processing enzyme of Drosophila melanogaster with multiple repeats of a cysteine motif. J Biol Chem 267(24):17208-15
Barr PJ, et al.  (1991) cDNA and gene structure for a human subtilisin-like protease with cleavage specificity for paired basic amino acid residues. DNA Cell Biol 10(5):319-28
Van de Ven WJ, et al.  (1991) Furin: the prototype mammalian subtilisin-like proprotein-processing enzyme. Endoproteolytic cleavage at paired basic residues of proproteins of the eukaryotic secretory pathway. Enzyme 45(5-6):257-70
Bresnahan PA, et al.  (1990) Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo. J Cell Biol 111(6 Pt 2):2851-9
Hatsuzawa K, et al.  (1990) Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells. J Biol Chem 265(36):22075-8