TKL1/YPR074C Literature Guide Help

Other names published for TKL1: transketolase TKL1, YPR074C

TKL1 - Mutants/Phenotypes (31)

ReferenceOther Genes Addressed
Ayer A, et al.  (2012) A genome-wide screen in yeast identifies specific oxidative stress genes required for the maintenance of sub-cellular redox homeostasis. PLoS One 7(9):e44278
Kowalska E, et al.  (2012) Altered expression and activities of enzymes involved in thiamine diphosphate biosynthesis in Saccharomyces cerevisiae under oxidative and osmotic stress. FEMS Yeast Res 12(5):534-46
Shen Y, et al.  (2012) An efficient xylose-fermenting recombinant Saccharomyces cerevisiae strain obtained through adaptive evolution and its global transcription profile. Appl Microbiol Biotechnol 96(4):1079-91
Bera AK, et al.  (2011) A genetic overhaul of Saccharomyces cerevisiae 424A(LNH-ST) to improve xylose fermentation. J Ind Microbiol Biotechnol 38(5):617-26
Clasquin MF, et al.  (2011) Riboneogenesis in yeast. Cell 145(6):969-80
Hasunuma T, et al.  (2011) Metabolic pathway engineering based on metabolomics confers acetic and formic acid tolerance to a recombinant xylose-fermenting strain of Saccharomyces cerevisiae. Microb Cell Fact 10(1):2
Kruger A, et al.  (2011) The pentose phosphate pathway is a metabolic redox sensor and regulates transcription during the antioxidant response. Antioxid Redox Signal 15(2):311-24
North M, et al.  (2011) Genome-wide functional profiling reveals genes required for tolerance to benzene metabolites in yeast. PLoS One 6(8):e24205
Toivari MH, et al.  (2010) Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol. Appl Microbiol Biotechnol 85(3):731-9
Bettiga M, et al.  (2009) Arabinose and xylose fermentation by recombinant Saccharomyces cerevisiae expressing a fungal pentose utilization pathway. Microb Cell Fact 8:40
Fong CS, et al.  (2008) Oxidant-induced cell-cycle delay in Saccharomyces cerevisiae: the involvement of the SWI6 transcription factor. FEMS Yeast Res 8(3):386-99
Matsufuji Y, et al.  (2008) Acetaldehyde tolerance in Saccharomyces cerevisiae involves the pentose phosphate pathway and oleic acid biosynthesis. Yeast 25(11):825-33
Ng CH, et al.  (2008) Adaptation to hydrogen peroxide in Saccharomyces cerevisiae: The role of NADPH-generating systems and the SKN7 transcription factor. Free Radic Biol Med 44(6):1131-45
Ni H, et al.  (2007) Transposon mutagenesis to improve the growth of recombinant Saccharomyces cerevisiae on D-xylose. Appl Environ Microbiol 73(7):2061-6
Toivari MH, et al.  (2007) Metabolic Engineering of Saccharomyces cerevisiae for Conversion of D-Glucose to Xylitol and Other Five-Carbon Sugars and Sugar Alcohols. Appl Environ Microbiol 73(17):5471-6
Gorsich SW, et al.  (2006) Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae. Appl Microbiol Biotechnol 71(3):339-49
Reiner S, et al.  (2006) A genomewide screen reveals a role of mitochondria in anaerobic uptake of sterols in yeast. Mol Biol Cell 17(1):90-103
Carter CD, et al.  (2005) Loss of SOD1 and LYS7 sensitizes Saccharomyces cerevisiae to hydroxyurea and DNA damage agents and downregulates MEC1 pathway effectors. Mol Cell Biol 25(23):10273-85
Esakova OA, et al.  (2005) Effects of transketolase cofactors on its conformation and stability. Life Sci 78(1):8-13
Golbik R, et al.  (2005) Effect of coenzyme modification on the structural and catalytic properties of wild-type transketolase and of the variant E418A from Saccharomyces cerevisiae. FEBS J 272(6):1326-42
Selivanov VA, et al.  (2004) Kinetic study of the H103A mutant yeast transketolase. FEBS Lett 567(2-3):270-4
Tucker CL and Fields S  (2004) Quantitative genome-wide analysis of yeast deletion strain sensitivities to oxidative and chemical stress. Comp Funct Genomics 5(3):216-24
Fiedler E, et al.  (2001) Examination of donor substrate conversion in yeast transketolase. J Biol Chem 276(19):16051-8
Meshalkina L, et al.  (1997) Examination of the thiamin diphosphate binding site in yeast transketolase by site-directed mutagenesis. Eur J Biochem 244(2):646-52
Nilsson U, et al.  (1997) Examination of substrate binding in thiamin diphosphate-dependent transketolase by protein crystallography and site-directed mutagenesis. J Biol Chem 272(3):1864-9
Walfridsson M, et al.  (1995) Xylose-metabolizing Saccharomyces cerevisiae strains overexpressing the TKL1 and TAL1 genes encoding the pentose phosphate pathway enzymes transketolase and transaldolase. Appl Environ Microbiol 61(12):4184-90
Wikner C, et al.  (1995) His103 in yeast transketolase is required for substrate recognition and catalysis. Eur J Biochem 233(3):750-5
Wikner C, et al.  (1994) Analysis of an invariant cofactor-protein interaction in thiamin diphosphate-dependent enzymes by site-directed mutagenesis. Glutamic acid 418 in transketolase is essential for catalysis. J Biol Chem 269(51):32144-50
Schaaff-Gerstenschlager I and Zimmermann FK  (1993) Pentose-phosphate pathway in Saccharomyces cerevisiae: analysis of deletion mutants for transketolase, transaldolase, and glucose 6-phosphate dehydrogenase. Curr Genet 24(5):373-6
Schaaff-Gerstenschlager I, et al.  (1993) TKL2, a second transketolase gene of Saccharomyces cerevisiae. Cloning, sequence and deletion analysis of the gene. Eur J Biochem 217(1):487-92