TIM10/YHR005C-A Literature Guide Help

Other names published for TIM10: MRS11, YHR005C-A

TIM10 - Mutants/Phenotypes (24)

ReferenceOther Genes Addressed
Baker MJ, et al.  (2012) Impaired folding of the mitochondrial small TIM chaperones induces clearance by the i-AAA protease. J Mol Biol 424(5):227-39
Reinhold R, et al.  (2012) The channel-forming Sym1 protein is transported by the TIM23 complex in a presequence-independent manner. Mol Cell Biol 32(24):5009-21
Papic D, et al.  (2011) Multispan mitochondrial outer membrane protein Ugo1 follows a unique Mim1-dependent import pathway. J Cell Biol 194(3):397-405
Hasson SA, et al.  (2010) Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation. Proc Natl Acad Sci U S A 107(21):9578-83
Baker MJ, et al.  (2009) Structural and functional requirements for activity of the Tim9-Tim10 complex in mitochondrial protein import. Mol Biol Cell 20(3):769-79
Sideris DP, et al.  (2009) A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding. J Cell Biol 187(7):1007-22
Breslow DK, et al.  (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8
Ivanova E, et al.  (2008) Assembly of the mitochondrial Tim9-Tim10 complex: a multi-step reaction with novel intermediates. J Mol Biol 375(1):229-39
Wagner K, et al.  (2008) The assembly pathway of the mitochondrial carrier translocase involves four preprotein translocases. Mol Cell Biol 28(13):4251-60
Milenkovic D, et al.  (2007) Biogenesis of the essential Tim9-Tim10 chaperone complex of mitochondria: site-specific recognition of cysteine residues by the intermembrane space receptor Mia40. J Biol Chem 282(31):22472-80
Sideris DP and Tokatlidis K  (2007) Oxidative folding of small Tims is mediated by site-specific docking onto Mia40 in the mitochondrial intermembrane space. Mol Microbiol 65(5):1360-73
Vergnolle MA, et al.  (2007) Mutation of Conserved Charged Residues in Mitochondrial TIM10 Subunits Precludes TIM10 Complex Assembly, but Does not Abolish Growth of Yeast Cells. J Mol Biol 371(5):1315-24
Brandner K, et al.  (2005) Taz1, an outer mitochondrial membrane protein, affects stability and assembly of inner membrane protein complexes: implications for Barth Syndrome. Mol Biol Cell 16(11):5202-14
Vergnolle MA, et al.  (2005) Distinct domains of small Tims involved in subunit interaction and substrate recognition. J Mol Biol 351(4):839-49
Wiedemann N, et al.  (2004) Biogenesis of the protein import channel Tom40 of the mitochondrial outer membrane: intermembrane space components are involved in an early stage of the assembly pathway. J Biol Chem 279(18):18188-94
Allen S, et al.  (2003) Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10. J Biol Chem 278(40):38505-13
Dunn CD and Jensen RE  (2003) Suppression of a defect in mitochondrial protein import identifies cytosolic proteins required for viability of yeast cells lacking mitochondrial DNA. Genetics 165(1):35-45
Senapin S, et al.  (2003) Transcription of TIM9, a new factor required for the petite-positive phenotype of Saccharomyces cerevisiae, is defective in spt7 mutants. Curr Genet 44(4):202-10
Truscott KN, et al.  (2002) Mitochondrial import of the ADP/ATP carrier: the essential TIM complex of the intermembrane space is required for precursor release from the TOM complex. Mol Cell Biol 22(22):7780-9
Murphy MP, et al.  (2001) The essential function of the small Tim proteins in the TIM22 import pathway does not depend on formation of the soluble 70-kilodalton complex. Mol Cell Biol 21(18):6132-8
Koehler CM, et al.  (2000) Tim18p, a new subunit of the TIM22 complex that mediates insertion of imported proteins into the yeast mitochondrial inner membrane. Mol Cell Biol 20(4):1187-93
Koehler CM, et al.  (1999) Human deafness dystonia syndrome is a mitochondrial disease. Proc Natl Acad Sci U S A 96(5):2141-6
Koehler CM, et al.  (1998) Import of mitochondrial carriers mediated by essential proteins of the intermembrane space. Science 279(5349):369-73
Jarosch E, et al.  (1997) A soluble 12-kDa protein of the mitochondrial intermembrane space, Mrs11p, is essential for mitochondrial biogenesis and viability of yeast cells. Mol Gen Genet 255(2):157-65