SEC63/YOR254C Literature Guide Help

Other names published for SEC63: PTL1, YOR254C

SEC63 - Mutants/Phenotypes (45)

ReferenceOther Genes Addressed
Rubenstein EM, et al.  (2012) Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase. J Cell Biol 197(6):761-73
Hu L, et al.  (2011) Predicting protein phenotypes based on protein-protein interaction network. PLoS One 6(3):e17668
Spiller MP and Stirling CJ  (2011) Preferential targeting of a signal recognition particle-dependent precursor to the Ssh1p translocon in yeast. J Biol Chem 286(25):21953-60
van der Zand A, et al.  (2010) Peroxisomal membrane proteins insert into the endoplasmic reticulum. Mol Biol Cell 21(12):2057-65
Perry RJ, et al.  (2009) Endoplasmic Reticulum-Associated Secretory Proteins Sec20p, Sec39p, and Dsl1p Are Involved in Peroxisome Biogenesis. Eukaryot Cell 8(6):830-843
Ungar L, et al.  (2009) A genome-wide screen for essential yeast genes that affect telomere length maintenance. Nucleic Acids Res 37(12):3840-9
Breslow DK, et al.  (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8
Yamamoto M, et al.  (2008) Arabidopsis thaliana has a set of J proteins in the endoplasmic reticulum that are conserved from yeast to animals and plants. Plant Cell Physiol 49(10):1547-62
Feng D, et al.  (2007) The transmembrane domain is sufficient for Sbh1p function, its association with the Sec61 complex, and interaction with Rtn1p. J Biol Chem 282(42):30618-28
Ng W, et al.  (2007) Characterization of the proteasome interaction with the Sec61 channel in the endoplasmic reticulum. J Cell Sci 120(Pt 4):682-91
Breinig F, et al.  (2006) Dissecting toxin immunity in virus-infected killer yeast uncovers an intrinsic strategy of self-protection. Proc Natl Acad Sci U S A 103(10):3810-5
Jermy AJ, et al.  (2006) The Brl domain in Sec63p is required for assembly of functional endoplasmic reticulum translocons. J Biol Chem 281(12):7899-906
Altmann K and Westermann B  (2005) Role of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae. Mol Biol Cell 16(11):5410-7
Willer M, et al.  (2003) An in vitro assay using overexpressed yeast SRP demonstrates that cotranslational translocation is dependent upon the J-domain of Sec63p. Biochemistry 42(23):7171-7
Yabal M, et al.  (2003) Translocation of the C terminus of a tail-anchored protein across the endoplasmic reticulum membrane in yeast mutants defective in signal peptide-driven translocation. J Biol Chem 278(5):3489-96
Fehrenbacher KL, et al.  (2002) Endoplasmic reticulum dynamics, inheritance, and cytoskeletal interactions in budding yeast. Mol Biol Cell 13(3):854-65
Morrow MW and Brodsky JL  (2001) Yeast ribosomes bind to highly purified reconstituted Sec61p complex and to mammalian p180. Traffic 2(10):705-16
Nishikawa SI, et al.  (2001) Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation. J Cell Biol 153(5):1061-70
Gillece P, et al.  (2000) The protein translocation channel mediates glycopeptide export across the endoplasmic reticulum membrane. Proc Natl Acad Sci U S A 97(9):4609-14
Kabani M, et al.  (2000) Sls1p stimulates Sec63p-mediated activation of Kar2p in a conformation-dependent manner in the yeast endoplasmic reticulum. Mol Cell Biol 20(18):6923-34
Brizzio V, et al.  (1999) Genetic interactions between KAR7/SEC71, KAR8/JEM1, KAR5, and KAR2 during nuclear fusion in Saccharomyces cerevisiae. Mol Biol Cell 10(3):609-26
Misselwitz B, et al.  (1998) J proteins catalytically activate Hsp70 molecules to trap a wide range of peptide sequences. Mol Cell 2(5):593-603
Matlack KE, et al.  (1997) Protein transport by purified yeast Sec complex and Kar2p without membranes. Science 277(5328):938-41
Plemper RK, et al.  (1997) Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation. Nature 388(6645):891-5
Ng DT and Walter P  (1996) ER membrane protein complex required for nuclear fusion. J Cell Biol 132(4):499-509
Ng DT, et al.  (1996) Signal sequences specify the targeting route to the endoplasmic reticulum membrane. J Cell Biol 134(2):269-78
Brodsky JL, et al.  (1995) BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum. Proc Natl Acad Sci U S A 92(21):9643-6
Johnson ES, et al.  (1995) A proteolytic pathway that recognizes ubiquitin as a degradation signal. J Biol Chem 270(29):17442-56
Lyman SK and Schekman R  (1995) Interaction between BiP and Sec63p is required for the completion of protein translocation into the ER of Saccharomyces cerevisiae. J Cell Biol 131(5):1163-71
Schlenstedt G, et al.  (1995) A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s. J Cell Biol 129(4):979-88