RNR1/YER070W Literature Guide Help

Other names published for RNR1: CRT7, RIR1, SDS12, ribonucleotide-diphosphate reductase subunit RNR1, YER070W

RNR1 - Mutants/Phenotypes (44)

ReferenceOther Genes Addressed
Ahmad F, et al.  (2012) Role of arginine 293 and glutamine 288 in communication between catalytic and allosteric sites in yeast ribonucleotide reductase. J Mol Biol 419(5):315-29
Poli J, et al.  (2012) dNTP pools determine fork progression and origin usage under replication stress. EMBO J 31(4):883-94
Poon BP and Mekhail K  (2012) Effects of Perinuclear Chromosome Tethers in the Telomeric URA3/5FOA System Reflect Changes to Gene Silencing and not Nucleotide Metabolism. Front Genet 3():144
Dosil M  (2011) Ribosome synthesis-unrelated functions of the preribosomal factor Rrp12 in cell cycle progression and the DNA damage response. Mol Cell Biol 31(12):2422-38
Gresham D, et al.  (2011) System-Level Analysis of Genes and Functions Affecting Survival During Nutrient Starvation in Saccharomyces cerevisiae. Genetics 187(1):299-317
Kumar D, et al.  (2011) Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools. Nucleic Acids Res 39(4):1360-71
Ma E, et al.  (2011) Giant yeast cells with nonrecyclable ribonucleotide reductase. Mol Genet Genomics 285(5):415-25
Tsaponina O, et al.  (2011) Ixr1 Is Required for the Expression of the Ribonucleotide Reductase Rnr1 and Maintenance of dNTP Pools. PLoS Genet 7(5):e1002061
Andreson BL, et al.  (2010) The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage. Nucleic Acids Res 38(19):6490-501
Koren A, et al.  (2010) MRC1-dependent scaling of the budding yeast DNA replication timing program. Genome Res 20(6):781-90
Kumar D, et al.  (2010) Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint. Nucleic Acids Res 38(12):3975-83
Ohnuki S, et al.  (2010) High-content, image-based screening for drug targets in yeast. PLoS One 5(4):e10177
Stumpf JD, et al.  (2010) mip1 Containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiae. Hum Mol Genet 19(11):2123-33
Singh I, et al.  (2009) Stringent mating-type-regulated auxotrophy increases the accuracy of systematic genetic interaction screens with Saccharomyces cerevisiae mutant arrays. Genetics 181(1):289-300
Sabouri N, et al.  (2008) Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage. Nucleic Acids Res 36(17):5660-7
Shima J, et al.  (2008) Possible roles of vacuolar H(+)-ATPase and mitochondrial function in tolerance to air-drying stress revealed by genome-wide screening of Saccharomyces cerevisiae deletion strains. Yeast 25(3):179-90
Chabes A and Stillman B  (2007) Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 104(4):1183-8
Cheng V, et al.  (2007) Genome-Wide Screen for Oxalate-Sensitive Mutants of Saccharomyces cerevisiae. Appl Environ Microbiol 73(18):5919-27
Lebedeva MA and Shadel GS  (2007) Cell cycle- and ribonucleotide reductase-driven changes in mtDNA copy number influence mtDNA Inheritance without compromising mitochondrial gene expression. Cell Cycle 6(16):2048-57
Weinberger M, et al.  (2007) DNA replication stress is a determinant of chronological lifespan in budding yeast. PLoS One 2(8):e748
Zhang Z, et al.  (2007) Role of the C terminus of the ribonucleotide reductase large subunit in enzyme regeneration and its inhibition by Sml1. Proc Natl Acad Sci U S A 104(7):2217-22
Baruffini E, et al.  (2006) Genetic and chemical rescue of the Saccharomyces cerevisiae phenotype induced by mitochondrial DNA polymerase mutations associated with progressive external ophthalmoplegia in humans. Hum Mol Genet 15(19):2846-55
Gatbonton T, et al.  (2006) Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS Genet 2(3):e35
Rand JD and Grant CM  (2006) The thioredoxin system protects ribosomes against stress-induced aggregation. Mol Biol Cell 17(1):387-401
Woolstencroft RN, et al.  (2006) Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length. J Cell Sci 119(Pt 24):5178-92
Carter CD, et al.  (2005) Loss of SOD1 and LYS7 sensitizes Saccharomyces cerevisiae to hydroxyurea and DNA damage agents and downregulates MEC1 pathway effectors. Mol Cell Biol 25(23):10273-85
Michel AH, et al.  (2005) Spontaneous rDNA copy number variation modulates Sir2 levels and epigenetic gene silencing. Genes Dev 19(10):1199-210
Raithatha SA and Stuart DT  (2005) Meiosis-specific regulation of the Saccharomyces cerevisiae S-phase cyclin CLB5 is dependent on MluI cell cycle box (MCB) elements in its promoter but is independent of MCB-binding factor activity. Genetics 169(3):1329-42
Sambade M, et al.  (2005) A genomic screen for yeast vacuolar membrane ATPase mutants. Genetics 170(4):1539-51
Taylor SD, et al.  (2005) The conserved Mec1/Rad53 nuclear checkpoint pathway regulates mitochondrial DNA copy number in Saccharomyces cerevisiae. Mol Biol Cell 16(6):3010-8