PRP8/YHR165C Literature Guide Help

Other names published for PRP8: DBF3, DNA39, RNA8, SLT21, USA2, YHR165C

PRP8 - Mutants/Phenotypes (47)

Results: 1 - 30 of 47 records
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ReferenceOther Genes Addressed
Query CC and Konarska MM  (2012) CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome. RNA 18(5):1001-13
Weber G, et al.  (2011) Mechanism for Aar2p function as a U5 snRNP assembly factor. Genes Dev 25(15):1601-12
Maeder C, et al.  (2009) ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8. Nat Struct Mol Biol 16(1):42-8
Pandit S, et al.  (2009) Spp382p interacts with multiple yeast splicing factors, including possible regulators of Prp43 DExD/H-Box protein function. Genetics 183(1):195-206
Pena V, et al.  (2008) Structure and function of an RNase H domain at the heart of the spliceosome. EMBO J 27(21):2929-40
Ritchie DB, et al.  (2008) Structural elucidation of a PRP8 core domain from the heart of the spliceosome. Nat Struct Mol Biol 15(11):1199-205
Wilmes GM, et al.  (2008) A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell 32(5):735-46
Yang K, et al.  (2008) Crystal structure of the {beta}-finger domain of Prp8 reveals analogy to ribosomal proteins. Proc Natl Acad Sci U S A 105(37):13817-22
Aronova A, et al.  (2007) Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing. RNA 13(9):1437-44
Boon KL, et al.  (2007) prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast. Nat Struct Mol Biol 14(11):1077-83
Liu L, et al.  (2007) Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing. Nat Struct Mol Biol 14(6):519-26
Pleiss JA, et al.  (2007) Rapid, transcript-specific changes in splicing in response to environmental stress. Mol Cell 27(6):928-37
Pleiss JA, et al.  (2007) Transcript specificity in yeast pre-mRNA splicing revealed by mutations in core spliceosomal components. PLoS Biol 5(4):e90
Bellare P, et al.  (2006) Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p. RNA 12(2):292-302
Boon KL, et al.  (2006) Prp8p dissection reveals domain structure and protein interaction sites. RNA 12(2):198-205
Konarska MM, et al.  (2006) Repositioning of the reaction intermediate within the catalytic center of the spliceosome. Mol Cell 21(4):543-53
Brenner TJ and Guthrie C  (2005) Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation. Genetics 170(3):1063-80
Lacadie SA and Rosbash M  (2005) Cotranscriptional spliceosome assembly dynamics and the role of U1 snRNA:5'ss base pairing in yeast. Mol Cell 19(1):65-75
Query CC and Konarska MM  (2004) Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants. Mol Cell 14(3):343-54
Schneider S, et al.  (2004) Motifs IV and V in the DEAH box splicing factor Prp22 are important for RNA unwinding, and helicase-defective Prp22 mutants are suppressed by Prp8. J Biol Chem 279(10):8617-26
Chawla G, et al.  (2003) Dependence of pre-mRNA introns on PRP17, a non-essential splicing factor: implications for efficient progression through cell cycle transitions. Nucleic Acids Res 31(9):2333-43
Kuhn AN, et al.  (2002) Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation. Proc Natl Acad Sci U S A 99(14):9145-9
Dagher SF and Fu XD  (2001) Evidence for a role of Sky1p-mediated phosphorylation in 3' splice site recognition involving both Prp8 and Prp17/Slu4. RNA 7(9):1284-97
van Nues RW and Beggs JD  (2001) Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae. Genetics 157(4):1451-67
Ben-Yehuda S, et al.  (2000) Extensive genetic interactions between PRP8 and PRP17/CDC40, two yeast genes involved in pre-mRNA splicing and cell cycle progression. Genetics 154(1):61-71
Ben-Yehuda S, et al.  (2000) Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae. Genetics 156(4):1503-17
Kuhn AN and Brow DA  (2000) Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation. Genetics 155(4):1667-82
Collins CA and Guthrie C  (1999) Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome. Genes Dev 13(15):1970-82
Kuhn AN, et al.  (1999) Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome. Mol Cell 3(1):65-75
Siatecka M, et al.  (1999) Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center. Genes Dev 13(15):1983-93
Results: 1 - 30 of 47 records
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