PRP16/YKR086W Literature Guide Help

Other names published for PRP16: RNA16, PRP23, DEAH-box RNA helicase PRP16, YKR086W

PRP16 - Mutants/Phenotypes (38)

ReferenceOther Genes Addressed
Aragon AD, et al.  (2012) Genomic analysis of Saccharomyces cerevisiae isolates that grow optimally with glucose as the sole carbon source. Electrophoresis 33(23):3514-20
Singh PK, et al.  (2012) Plasmodium falciparum Prp16 homologue and its role in splicing. Biochim Biophys Acta 1819(11-12):1186-99
Tseng CK, et al.  (2011) DEAH-box ATPase Prp16 has dual roles in remodeling of the spliceosome in catalytic steps. RNA 17(1):145-54
Koodathingal P, et al.  (2010) The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicing. Mol Cell 39(3):385-95
Lardelli RM, et al.  (2010) Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing. RNA 16(3):516-28
Mefford MA and Staley JP  (2009) Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps. RNA 15(7):1386-97
Smith DJ, et al.  (2009) Insights into branch nucleophile positioning and activation from an orthogonal pre-mRNA splicing system in yeast. Mol Cell 34(3):333-43
Schwer B  (2008) A conformational rearrangement in the spliceosome sets the stage for Prp22-dependent mRNA release. Mol Cell 30(6):743-54
Wilmes GM, et al.  (2008) A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell 32(5):735-46
Hilliker AK, et al.  (2007) U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing. Genes Dev 21(7):821-34
Liu L, et al.  (2007) Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing. Nat Struct Mol Biol 14(6):519-26
Perriman RJ and Ares M Jr  (2007) Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing. Genes Dev 21(7):811-20
Pleiss JA, et al.  (2007) Transcript specificity in yeast pre-mRNA splicing revealed by mutations in core spliceosomal components. PLoS Biol 5(4):e90
Brenner TJ and Guthrie C  (2005) Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation. Genetics 170(3):1063-80
Davierwala AP, et al.  (2005) The synthetic genetic interaction spectrum of essential genes. Nat Genet 37(10):1147-52
Villa T and Guthrie C  (2005) The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing. Genes Dev 19(16):1894-904
Query CC and Konarska MM  (2004) Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants. Mol Cell 14(3):343-54
Chawla G, et al.  (2003) Dependence of pre-mRNA introns on PRP17, a non-essential splicing factor: implications for efficient progression through cell cycle transitions. Nucleic Acids Res 31(9):2333-43
Vincent K, et al.  (2003) Genetic interactions with CLF1 identify additional pre-mRNA splicing factors and a link between activators of yeast vesicular transport and splicing. Genetics 164(3):895-907
Schneider S, et al.  (2002) Characterization of dominant-negative mutants of the DEAH-box splicing factors Prp22 and Prp16. J Biol Chem 277(18):15452-8
Biggins S, et al.  (2001) Genes involved in sister chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae. Genetics 159(2):453-70
Ben-Yehuda S, et al.  (2000) Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae. Genetics 156(4):1503-17
Brodsky AS and Silver PA  (2000) Pre-mRNA processing factors are required for nuclear export. RNA 6(12):1737-49
Chanfreau G, et al.  (1999) Trans-complementation of the second step of pre-mRNA splicing by exogenous 5' exons. RNA 5(7):876-82
Kim DH and Rossi JJ  (1999) The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex. RNA 5(7):959-71
Hotz HR and Schwer B  (1998) Mutational analysis of the yeast DEAH-box splicing factor Prp16. Genetics 149(2):807-15
Wang Y and Guthrie C  (1998) PRP16, a DEAH-box RNA helicase, is recruited to the spliceosome primarily via its nonconserved N-terminal domain. RNA 4(10):1216-29
Xu D, et al.  (1998) Synthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicing. Mol Cell Biol 18(4):2055-66
Maddock JR, et al.  (1996) Six novel genes necessary for pre-mRNA splicing in Saccharomyces cerevisiae. Nucleic Acids Res 24(6):1037-44
Noble SM and Guthrie C  (1996) Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Genetics 143(1):67-80