PKH1/YDR490C Literature Guide Help

Other names published for PKH1: YDR490C

PKH1 - Mutants/Phenotypes (29)

ReferenceOther Genes Addressed
Haesendonckx S, et al.  (2012) The activation loop of PKA catalytic isoforms is differentially phosphorylated by Pkh protein kinases in Saccharomyces cerevisiae. Biochem J 448(3):307-20
Huang X, et al.  (2012) Down-regulating sphingolipid synthesis increases yeast lifespan. PLoS Genet 8(2):e1002493
Kimpe M, et al.  (2012) Pkh1 interacts with and phosphorylates components of the yeast Gcn2/eIF2a system. Biochem Biophys Res Commun 419(1):89-94
Lee YJ, et al.  (2012) Sphingolipid signaling mediates iron toxicity. Cell Metab 16(1):90-6
Montefusco DJ, et al.  (2012) Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability. J Biol Chem 287(12):9280-9
Morvan J, et al.  (2012) Pkh1/2-dependent phosphorylation of Vps27 regulates ESCRT-I recruitment to endosomes. Mol Biol Cell 23(20):4054-64
Nelson Dittrich AC and Devarenne TP  (2012) Characterization of a PDK1 homologue from the moss Physcomitrella patens. Plant Physiol 158(2):1018-33
Baxter BK, et al.  (2011) Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules. ACS Chem Biol 6(5):502-10
Brach T, et al.  (2011) Reassessment of the role of plasma membrane domains in the regulation of vesicular traffic in yeast. J Cell Sci 124(Pt 3):328-37
Luo G, et al.  (2011) Nutrients and the Pkh1/2 and Pkc1 Protein Kinases Control mRNA Decay and P-body Assembly in Yeast. J Biol Chem 286(11):8759-70
Voordeckers K, et al.  (2011) Yeast 3-phosphoinositide-dependent protein kinase-1 (PDK1) orthologs Pkh1-3 differentially regulate phosphorylation of protein kinase A (PKA) and the protein kinase B (PKB)/S6K ortholog Sch9. J Biol Chem 286(25):22017-27
Roelants FM, et al.  (2010) A protein kinase network regulates the function of aminophospholipid flippases. Proc Natl Acad Sci U S A 107(1):34-9
Frohlich F, et al.  (2009) A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling. J Cell Biol 185(7):1227-42
Villa NY, et al.  (2009) Sphingolipids function as downstream effectors of a fungal PAQR. Mol Pharmacol 75(4):866-75
Luo G, et al.  (2008) The sphingolipid long-chain base-Pkh1/2-Ypk1/2 signaling pathway regulates eisosome assembly and turnover. J Biol Chem 283(16):10433-44
Zabrocki P, et al.  (2008) Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson. Biochim Biophys Acta 1783(10):1767-80
Daquinag A, et al.  (2007) The yeast PH domain proteins Slm1 and Slm2 are targets of sphingolipid signaling during the response to heat stress. Mol Cell Biol 27(2):633-50
Urban J, et al.  (2007) Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell 26(5):663-74
Walther TC, et al.  (2007) Pkh-kinases control eisosome assembly and organization. EMBO J 26(24):4946-55
Grosshans BL, et al.  (2006) TEDS site phosphorylation of the yeast myosins I is required for ligand-induced but not for constitutive endocytosis of the G protein-coupled receptor Ste2p. J Biol Chem 281(16):11104-14
Meier KD, et al.  (2006) Sphingoid base is required for translation initiation during heat stress in Saccharomyces cerevisiae. Mol Biol Cell 17(3):1164-75
Rodriguez-Escudero I, et al.  (2005) Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast. Biochem J 390(Pt 2):613-23
Baetz K, et al.  (2004) Yeast genome-wide drug-induced haploinsufficiency screen to determine drug mode of action. Proc Natl Acad Sci U S A 101(13):4525-30
Roelants FM, et al.  (2002) Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Mol Biol Cell 13(9):3005-28
deHart AK, et al.  (2002) The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast. J Cell Biol 156(2):241-8
Friant S, et al.  (2001) Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. EMBO J 20(23):6783-92
Zhu H, et al.  (2000) Analysis of yeast protein kinases using protein chips. Nat Genet 26(3):283-9
Casamayor A, et al.  (1999) Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol 9(4):186-97
Inagaki M, et al.  (1999) PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast. Mol Cell Biol 19(12):8344-52