MCM5/YLR274W Literature Guide Help

Other names published for MCM5: BOB1, CDC46, YLR274W

MCM5 - Mutants/Phenotypes (50)

ReferenceOther Genes Addressed
Cheng E, et al.  (2012) Genome rearrangements caused by depletion of essential DNA replication proteins in Saccharomyces cerevisiae. Genetics 192(1):147-60
Zhang Y, et al.  (2012) Genome-wide screen identifies pathways that govern GAA/TTC repeat fragility and expansions in dividing and nondividing yeast cells. Mol Cell 48(2):254-65
Gancarz BL, et al.  (2011) Systematic identification of novel, essential host genes affecting bromovirus RNA replication. PLoS One 6(8):e23988
Power P, et al.  (2011) Sub-Telomeric core X and Y' Elements in S.cerevisiae Suppress Extreme Variations in Gene Silencing. PLoS One 6(3):e17523
Baker SP, et al.  (2010) Histone H3 Thr 45 phosphorylation is a replication-associated post-translational modification in S. cerevisiae. Nat Cell Biol 12(3):294-8
Bochman ML and Schwacha A  (2010) The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'. Nucleic Acids Res 38(18):6078-88
Espinosa MC, et al.  (2010) GCN5 Is a Positive Regulator of Origins of DNA Replication in Saccharomyces cerevisiae. PLoS One 5(1):e8964
Ma L, et al.  (2010) Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae. Cell Cycle 9(21):4399-410
Sheu YJ and Stillman B  (2010) The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4. Nature 463(7277):113-7
Zegerman P and Diffley JF  (2010) Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation. Nature 467(7314):474-8
Bivi N, et al.  (2009) Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection. Genome Biol 10(9):R93
Rehman MA, et al.  (2009) Subtelomeric ACS-containing proto-silencers act as antisilencers in replication factors mutants in Saccharomyces cerevisiae. Mol Biol Cell 20(2):631-41
Stead BE, et al.  (2009) ATP binding and hydrolysis by Mcm2 regulate DNA binding by Mcm complexes. J Mol Biol 391(2):301-13
Steere NA, et al.  (2009) Functional screen of human MCM2-7 variant alleles for disease-causing potential. Mutat Res 666(1-2):74-8
Tittel-Elmer M, et al.  (2009) The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress. EMBO J 28(8):1142-56
Bochman ML, et al.  (2008) Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability. Mol Cell Biol 28(19):5865-73
Breslow DK, et al.  (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8
Devault A, et al.  (2008) Interplay between S-Cyclin-dependent Kinase and Dbf4-dependent Kinase in Controlling DNA Replication through Phosphorylation of Yeast Mcm4 N-Terminal Domain. Mol Biol Cell 19(5):2267-77
Leon RP, et al.  (2008) Functional Conservation of {beta}-Hairpin DNA Binding Domains in the Mcm Protein of Methanobacterium thermoautotrophicum and the Mcm5 protein of Saccharomyces cerevisiae. Genetics 179(4):1757-68
Lo HC, et al.  (2008) Cdc7-Dbf4 regulates NDT80 transcription as well as reductional segregation during budding yeast meiosis. Mol Biol Cell 19(11):4956-67
Matos J, et al.  (2008) Dbf4-dependent CDC7 kinase links DNA replication to the segregation of homologous chromosomes in meiosis I. Cell 135(4):662-78
Ogi H, et al.  (2008) The role of the Saccharomyces cerevisiae Cdc7-Dbf4 complex in the replication checkpoint. Gene 414(1-2):32-40
Bochman ML and Schwacha A  (2007) Differences in the single-stranded DNA binding activities of MCM2-7 and MCM467: MCM2 and MCM5 define a slow ATP-dependent step. J Biol Chem 282(46):33795-804
Hoang ML, et al.  (2007) Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae. Mol Cell Biol 27(21):7594-602
Zegerman P and Diffley JF  (2007) Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445(7125):281-5
Dohrmann PR and Sclafani RA  (2006) Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae. Genetics 174(1):87-99
Rehman MA, et al.  (2006) Differential requirement of DNA replication factors for subtelomeric ARS consensus sequence protosilencers in Saccharomyces cerevisiae. Genetics 174(4):1801-10
Yu L, et al.  (2006) A survey of essential gene function in the yeast cell division cycle. Mol Biol Cell 17(11):4736-47
Chen YJ, et al.  (2005) Structural polymorphism of Methanothermobacter thermautotrophicus MCM. J Mol Biol 346(2):389-94
Nieduszynski CA, et al.  (2005) The requirement of yeast replication origins for pre-replication complex proteins is modulated by transcription. Nucleic Acids Res 33(8):2410-20