HRD3/YLR207W Literature Guide Help

Other names published for HRD3: ubiquitin ligase complex subunit HRD3, YLR207W

HRD3 - Mutants/Phenotypes (28)

ReferenceOther Genes Addressed
Izawa T, et al.  (2012) Yos9p and Hrd1p mediate ER retention of misfolded proteins for ER-associated degradation. Mol Biol Cell 23(7):1283-93
Li S, et al.  (2012) Cytosolic entry of shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active hrd1p. PLoS One 7(7):e41119
North M, et al.  (2012) Genome-Wide Functional Profiling Identifies Genes and Processes Important for Zinc-Limited Growth of Saccharomyces cerevisiae. PLoS Genet 8(6):e1002699
Rubenstein EM, et al.  (2012) Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase. J Cell Biol 197(6):761-73
Chantret I, et al.  (2011) Endoplasmic reticulum-associated degradation (ERAD) and free oligosaccharide generation in Saccharomyces cerevisiae. J Biol Chem 286(48):41786-800
Carvalho P, et al.  (2010) Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell 143(4):579-91
Li S, et al.  (2010) Folding-competent and Folding-defective Forms of Ricin A Chain Have Different Fates after Retrotranslocation from the Endoplasmic Reticulum. Mol Biol Cell 21(15):2543-54
Garza RM, et al.  (2009) In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase. J Biol Chem 284(22):14710-22
Horn SC, et al.  (2009) Usa1 functions as a scaffold of the HRD-ubiquitin ligase. Mol Cell 36(5):782-93
Jonikas MC, et al.  (2009) Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323(5922):1693-7
Sato BK, et al.  (2009) Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase. Mol Cell 34(2):212-22
Schafer A and Wolf DH  (2009) Sec61p is part of the endoplasmic reticulum-associated degradation machinery. EMBO J 28(19):2874-84
Boer VM, et al.  (2008) Influence of genotype and nutrition on survival and metabolism of starving yeast. Proc Natl Acad Sci U S A 105(19):6930-5
Mazon MJ, et al.  (2007) Efficient degradation of misfolded mutant Pma1 by endoplasmic reticulum-associated degradation requires Atg19 and the Cvt/autophagy pathway. Mol Microbiol 63(4):1069-1077
Apodaca J, et al.  (2006) Cellular tolerance of prion protein PrP in yeast involves proteolysis and the unfolded protein response. Biochem Biophys Res Commun 347(1):319-26
Bazirgan OA, et al.  (2006) Determinants of RING-E2 fidelity for Hrd1p, a membrane-anchored ubiquitin ligase. J Biol Chem 281(51):38989-9001
Denic V, et al.  (2006) A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation. Cell 126(2):349-59
Liao M, et al.  (2006) Endoplasmic reticulum-associated degradation of cytochrome P450 CYP3A4 in Saccharomyces cerevisiae: further characterization of cellular participants and structural determinants. Mol Pharmacol 69(6):1897-904
Sliwa P and Korona R  (2005) Loss of dispensable genes is not adaptive in yeast. Proc Natl Acad Sci U S A 102(49):17670-4
Taxis C, et al.  (2002) ER-golgi traffic is a prerequisite for efficient ER degradation. Mol Biol Cell 13(6):1806-18
Gardner RG, et al.  (2001) In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. Mol Cell Biol 21(13):4276-91
Murray BP and Correia MA  (2001) Ubiquitin-dependent 26S proteasomal pathway: a role in the degradation of native human liver CYP3A4 expressed in Saccharomyces cerevisiae? Arch Biochem Biophys 393(1):106-16
Walter J, et al.  (2001) Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p. EMBO J 20(12):3124-31
Wilhovsky S, et al.  (2000) HRD gene dependence of endoplasmic reticulum-associated degradation. Mol Biol Cell 11(5):1697-708
Bordallo J and Wolf DH  (1999) A RING-H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae. FEBS Lett 448(2-3):244-8
Plemper RK, et al.  (1999) Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation. J Cell Sci 112 ( Pt 22)():4123-34
Saito Y, et al.  (1999) Identification of SEC12, SED4, truncated SEC16, and EKS1/HRD3 as multicopy suppressors of ts mutants of Sar1 GTPase. J Biochem 125(1):130-7
Hampton RY, et al.  (1996) Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell 7(12):2029-44