HMG2/YLR450W Literature Guide Help

Other names published for HMG2: hydroxymethylglutaryl-CoA reductase (NADPH) HMG2, YLR450W

HMG2 - Mutants/Phenotypes (24)

ReferenceOther Genes Addressed
Brodersen P, et al.  (2012) Isoprenoid biosynthesis is required for miRNA function and affects membrane association of ARGONAUTE 1 in Arabidopsis. Proc Natl Acad Sci U S A 109(5):1778-83
Dai Z, et al.  (2011) Cloning and characterization of a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Salvia miltiorrhiza involved in diterpenoid tanshinone accumulation. J Plant Physiol 168(2):148-57
Ignea C, et al.  (2011) Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids. Microb Cell Fact 10():4
Reid RJ, et al.  (2011) Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Genome Res 21(3):477-86
Theesfeld CL, et al.  (2011) The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2. J Biol Chem 286(30):26298-307
Mantzouridou F and Tsimidou MZ  (2010) Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6. FEMS Yeast Res 10(6):699-707
Ohnuki S, et al.  (2010) High-content, image-based screening for drug targets in yeast. PLoS One 5(4):e10177
Garza RM, et al.  (2009) Geranylgeranyl Pyrophosphate Is a Potent Regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA Reductase Degradation in Yeast. J Biol Chem 284(51):35368-80
Leszczynska A, et al.  (2009) Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. PLoS One 4(12):e8499
Wysocka-Kapcinska M, et al.  (2009) Functional expression of human HMG-CoA reductase in Saccharomyces cerevisiae: a system to analyse normal and mutated versions of the enzyme in the context of statin treatment. J Appl Microbiol 106(3):895-902
Federovitch CM, et al.  (2008) Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae. Mol Biol Cell 19(10):4506-20
Loertscher J, et al.  (2006) Endoplasmic reticulum-associated degradation is required for cold adaptation and regulation of sterol biosynthesis in the yeast Saccharomyces cerevisiae. Eukaryot Cell 5(4):712-22
Giaever G, et al.  (2004) Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Proc Natl Acad Sci U S A 101(3):793-8
Enyenihi AH and Saunders WS  (2003) Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163(1):47-54
Gardner RG, et al.  (2001) In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. Mol Cell Biol 21(13):4276-91
Gardner RG and Hampton RY  (1999) A 'distributed degron' allows regulated entry into the ER degradation pathway. EMBO J 18(21):5994-6004
Kennedy MA, et al.  (1999) Transcriptional regulation of the squalene synthase gene (ERG9) in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1445(1):110-22
Gardner R, et al.  (1998) Sequence determinants for regulated degradation of yeast 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell 9(9):2611-26
Koning AJ, et al.  (1996) Different subcellular localization of Saccharomyces cerevisiae HMG-CoA reductase isozymes at elevated levels corresponds to distinct endoplasmic reticulum membrane proliferations. Mol Biol Cell 7(5):769-89
Casey WM, et al.  (1992) Regulation of partitioned sterol biosynthesis in Saccharomyces cerevisiae. J Bacteriol 174(22):7283-8
Bard M, et al.  (1988) Isolation and characterization of mevinolin resistant mutants of Saccharomyces cerevisiae. J Gen Microbiol 134(4):1071-8
Wright R, et al.  (1988) Increased amounts of HMG-CoA reductase induce "karmellae": a proliferation of stacked membrane pairs surrounding the yeast nucleus. J Cell Biol 107(1):101-14
Basson ME, et al.  (1986) Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proc Natl Acad Sci U S A 83(15):5563-7
Rine J, et al.  (1983) Targeted selection of recombinant clones through gene dosage effects. Proc Natl Acad Sci U S A 80(22):6750-4