GEF1/YJR040W Literature Guide Help

Other names published for GEF1: CLC, YJR040W

GEF1 - Mutants/Phenotypes (23)

ReferenceOther Genes Addressed
Dos Santos SC and Sa-Correia I  (2011) A genome-wide screen identifies yeast genes required for protection against or enhanced cytotoxicity of the antimalarial drug quinine. Mol Genet Genomics 286(5-6):333-46
Fell GL, et al.  (2011) Identification of yeast genes involved in k homeostasis: loss of membrane traffic genes affects k uptake. G3 (Bethesda) 1(1):43-56
Minear S, et al.  (2011) Curcumin inhibits growth of Saccharomyces cerevisiae through iron chelation. Eukaryot Cell 10(11):1574-81
Braun NA, et al.  (2010) The yeast CLC protein counteracts vesicular acidification during iron starvation. J Cell Sci 123(Pt 13):2342-50
Wege S, et al.  (2010) The proline 160 in the selectivity filter of the Arabidopsis NO(3) (-) /H(+) exchanger AtCLCa is essential for nitrate accumulation in planta. Plant J 63(5):861-9
Jo WJ, et al.  (2009) Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae. BMC Genomics 10:130
Jennings ML and Cui J  (2008) Chloride homeostasis in Saccharomyces cerevisiae: high affinity influx, V-ATPase-dependent sequestration, and identification of a candidate Cl- sensor. J Gen Physiol 131(4):379-91
Lopez-Rodriguez A, et al.  (2007) The product of the gene GEF1 of Saccharomyces cerevisiae transports Cl across the plasma membrane. FEMS Yeast Res 7(8):1218-29
Marmagne A, et al.  (2007) Two members of the Arabidopsis CLC (chloride channel) family, AtCLCe and AtCLCf, are associated with thylakoid and Golgi membranes, respectively. J Exp Bot 58(12):3385-93
Oddon DM, et al.  (2007) A CLC chloride channel plays an essential role in copper homeostasis in Aspergillus nidulans at increased extracellular copper concentrations. Biochim Biophys Acta 1768(10):2466-77
Metz J, et al.  (2006) The yeast Arr4p ATPase binds the chloride transporter Gef1p when copper is available in the cytosol. J Biol Chem 281(1):410-7
Flis K, et al.  (2005) The functioning of mammalian ClC-2 chloride channel in Saccharomyces cerevisiae cells requires an increased level of Kha1p. Biochem J 390(Pt 3):655-64
Wachter A and Schwappach B  (2005) The yeast CLC chloride channel is proteolytically processed by the furin-like protease Kex2p in the first extracellular loop. FEBS Lett 579(5):1149-53
Davis-Kaplan SR, et al.  (2004) Genome-wide analysis of iron-dependent growth reveals a novel yeast gene required for vacuolar acidification. J Biol Chem 279(6):4322-9
Dimmer KS, et al.  (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53
Flis K, et al.  (2002) The Gef1 protein of Saccharomyces cerevisiae is associated with chloride channel activity. Biochem Biophys Res Commun 294(5):1144-50
Bowers K, et al.  (2000) The sodium/proton exchanger Nhx1p is required for endosomal protein trafficking in the yeast Saccharomyces cerevisiae. Mol Biol Cell 11(12):4277-94
Perzov N, et al.  (2000) Altered distribution of the yeast plasma membrane H+-ATPase as a feature of vacuolar H+-ATPase null mutants. J Biol Chem 275(51):40088-95
Davis-Kaplan SR, et al.  (1998) Chloride is an allosteric effector of copper assembly for the yeast multicopper oxidase Fet3p: an unexpected role for intracellular chloride channels. Proc Natl Acad Sci U S A 95(23):13641-5
Gaxiola RA, et al.  (1998) The yeast CLC chloride channel functions in cation homeostasis. Proc Natl Acad Sci U S A 95(7):4046-50
Li L and Kaplan J  (1998) Defects in the yeast high affinity iron transport system result in increased metal sensitivity because of the increased expression of transporters with a broad transition metal specificity. J Biol Chem 273(35):22181-7
Schwappach B, et al.  (1998) Golgi localization and functionally important domains in the NH2 and COOH terminus of the yeast CLC putative chloride channel Gef1p. J Biol Chem 273(24):15110-8
Greene JR, et al.  (1993) The GEF1 gene of Saccharomyces cerevisiae encodes an integral membrane protein; mutations in which have effects on respiration and iron-limited growth. Mol Gen Genet 241(5-6):542-53