GCN4/YEL009C Literature Guide Help

Other names published for GCN4: AAS3, ARG9, AAS101, YEL009C

GCN4 - Mutants/Phenotypes (209)

ReferenceOther Genes Addressed
Delaney JR, et al.  (2013) Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell 12(1):156-66
Harsch MJ and Gardner RC  (2013) Yeast genes involved in sulfur and nitrogen metabolism affect the production of volatile thiols from Sauvignon Blanc musts. Appl Microbiol Biotechnol 97(1):223-35
Crisucci EM and Arndt KM  (2012) Paf1 restricts Gcn4 occupancy and antisense transcription at the ARG1 promoter. Mol Cell Biol 32(6):1150-63
Nikolaev Y and Pervushin K  (2012) Structural basis of RNA binding by leucine zipper GCN4. Protein Sci 21(5):667-76
Rosonina E, et al.  (2012) Sumoylation of transcription factor Gcn4 facilitates its Srb10-mediated clearance from promoters in yeast. Genes Dev 26(4):350-5
Torbensen R, et al.  (2012) Amino Acid Transporter Genes Are Essential for FLO11-Dependent and FLO11-Independent Biofilm Formation and Invasive Growth in Saccharomyces cerevisiae. PLoS One 7(7):e41272
Brzovic PS, et al.  (2011) The acidic transcription activator gcn4 binds the mediator subunit gal11/med15 using a simple protein interface forming a fuzzy complex. Mol Cell 44(6):942-53
Gresham D, et al.  (2011) System-Level Analysis of Genes and Functions Affecting Survival During Nutrient Starvation in Saccharomyces cerevisiae. Genetics 187(1):299-317
Hernandez H, et al.  (2011) Gln3-Gcn4 hybrid transcriptional activator determines catabolic and biosynthetic gene expression in the yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun 404(3):859-64
Herzog B, et al.  (2011) A Feedback Circuit between Transcriptional Activation and Self-Destruction of Gcn4 Separates Its Metabolic and Morphogenic Response in Diploid Yeasts. J Mol Biol 405(4):909-25
Hong S and Yoon S  (2011) Mcm1p binding sites in the ARG1 promoter positively regulate ARG1 transcription and S. cerevisiae growth in the absence of arginine and Gcn4p. Amino Acids 40(2):623-31
Iglesias-Gato D, et al.  (2011) Guanine Nucleotide Pool Imbalance Impairs Multiple Steps of Protein Synthesis and Disrupts GCN4 Translational Control in Saccharomyces cerevisiae. Genetics 187(1):105-22
Joo YJ, et al.  (2011) Gcn4p-mediated transcriptional repression of ribosomal protein genes under amino-acid starvation. EMBO J 30(5):859-72
Kruegel U, et al.  (2011) Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae. PLoS Genet 7(9):e1002253
Mahrenholz CC, et al.  (2011) Complex networks govern coiled-coil oligomerization - predicting and profiling by means of a machine learning approach. Mol Cell Proteomics 10(5):M110.004994
Molin M, et al.  (2011) Life Span Extension and H(2)O(2) Resistance Elicited by Caloric Restriction Require the Peroxiredoxin Tsa1 in Saccharomyces cerevisiae. Mol Cell 43(5):823-33
Sun Z, et al.  (2011) Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS. PLoS Biol 9(4):e1000614
Teixeira MC, et al.  (2011) Yeast response and tolerance to polyamine toxicity involving the drug : H+ antiporter Qdr3 and the transcription factors Yap1 and Gcn4. Microbiology 157(Pt 4):945-56
Uluisik I, et al.  (2011) Boron stress activates the general amino acid control mechanism and inhibits protein synthesis. PLoS One 6(11):e27772
Zhang F and Hinnebusch AG  (2011) An upstream ORF with non-AUG start codon is translated in vivo but dispensable for translational control of GCN4 mRNA. Nucleic Acids Res 39(8):3128-40
Cherkasova V, et al.  (2010) Snf1 promotes phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4. Mol Cell Biol 30(12):2862-73
Diao J  (2010) Crystal structure of a super leucine zipper, an extended two-stranded super long coiled coil. Protein Sci 19(2):319-26
Ecker N, et al.  (2010) Induction of autophagic flux by amino acid deprivation is distinct from nitrogen starvation-induced macroautophagy. Autophagy 6(7):879-90
Fendt SM, et al.  (2010) Unraveling condition-dependent networks of transcription factors that control metabolic pathway activity in yeast. Mol Syst Biol 6():432
Govind CK, et al.  (2010) Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes. Mol Cell 39(2):234-46
Herbig E, et al.  (2010) Mechanism of Mediator recruitment by tandem Gcn4 activation domains and three Gal11 activator-binding domains. Mol Cell Biol 30(10):2376-90
Jedidi I, et al.  (2010) Activator Gcn4 employs multiple segments of Med15/Gal11, including the KIX domain, to recruit mediator to target genes in vivo. J Biol Chem 285(4):2438-55
Kingsbury JM and McCusker JH  (2010) Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation. Eukaryot Cell 9(5):729-37
Lin CA, et al.  (2010) The sua5 protein is essential for normal translational regulation in yeast. Mol Cell Biol 30(1):354-63
Morgan SA and Woolley GA  (2010) A photoswitchable DNA-binding protein based on a truncated GCN4-photoactive yellow protein chimera. Photochem Photobiol Sci 9(10):1320-6