GCN2/YDR283C Literature Guide Help

Other names published for GCN2: AAS1, NDR2, AAS102, YDR283C

GCN2 - Mutants/Phenotypes (105)

ReferenceOther Genes Addressed
Cap M, et al.  (2012) Cell differentiation within a yeast colony: metabolic and regulatory parallels with a tumor-affected organism. Mol Cell 46(4):436-48
Hofmann S, et al.  (2012) Translation suppression promotes stress granule formation and cell survival in response to cold shock. Mol Biol Cell 23(19):3786-800
Hueso G, et al.  (2012) A novel role for protein kinase Gcn2 in yeast tolerance to intracellular acid stress. Biochem J 441(1):255-64
Kimpe M, et al.  (2012) Pkh1 interacts with and phosphorylates components of the yeast Gcn2/eIF2a system. Biochem Biophys Res Commun 419(1):89-94
Reid PJ, et al.  (2012) Identification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, the nucleotide exchange factor for translation initiation. J Biol Chem 287(11):8275-85
Rodriguez-Hernandez CJ, et al.  (2012) Anti-diabetic and anti-obesity agent sodium tungstate enhances GCN pathway activation through Glc7p inhibition. FEBS Lett 586(3):270-6
Visweswaraiah J, et al.  (2012) Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation. J Biol Chem 287(45):37757-68
Alabrudzinska M, et al.  (2011) Dipoid-Specific Genome Stability Genes of S. cerevisiae: Genomic Screen Reveals Haploidization as an Escape from Persisting DNA Rearrangement Stress. PLoS One 6(6):e21124
Elsby R, et al.  (2011) The alpha subunit of eukaryotic initiation factor 2B (eIF2B) is required for eIF2-mediated translational suppression of vesicular stomatitis virus. J Virol 85(19):9716-25
Franzosa EA, et al.  (2011) Heterozygous yeast deletion collection screens reveal essential targets of hsp90. PLoS One 6(11):e28211
Iglesias-Gato D, et al.  (2011) Guanine Nucleotide Pool Imbalance Impairs Multiple Steps of Protein Synthesis and Disrupts GCN4 Translational Control in Saccharomyces cerevisiae. Genetics 187(1):105-22
Kato K, et al.  (2011) Severe ethanol stress induces assembly of stress granules in Saccharomyces cerevisiae. Yeast 28(5):339-47
Molin M, et al.  (2011) Life Span Extension and H(2)O(2) Resistance Elicited by Caloric Restriction Require the Peroxiredoxin Tsa1 in Saccharomyces cerevisiae. Mol Cell 43(5):823-33
Uluisik I, et al.  (2011) Boron stress activates the general amino acid control mechanism and inhibits protein synthesis. PLoS One 6(11):e27772
Visweswaraiah J, et al.  (2011) Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity. J Biol Chem 286(42):36568-79
Cherkasova V, et al.  (2010) Snf1 promotes phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4. Mol Cell Biol 30(12):2862-73
Ecker N, et al.  (2010) Induction of autophagic flux by amino acid deprivation is distinct from nitrogen starvation-induced macroautophagy. Autophagy 6(7):879-90
Elantak L, et al.  (2010) The Indispensable N-Terminal Half of eIF3j/HCR1 Cooperates with its Structurally Conserved Binding Partner eIF3b/PRT1-RRM and with eIF1A in Stringent AUG Selection. J Mol Biol 396(4):1097-1116
Kilchert C, et al.  (2010) Defects in the Secretory Pathway and High Ca2+ Induce Multiple P-bodies. Mol Biol Cell 21(15):2624-38
Lin CA, et al.  (2010) The sua5 protein is essential for normal translational regulation in yeast. Mol Cell Biol 30(1):354-63
Moravcevic K, et al.  (2010) Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids. Cell 143(6):966-77
Nomura W, et al.  (2010) Methylglyoxal activates Gcn2 to phosphorylate eIF2alpha independently of the TOR pathway in Saccharomyces cerevisiae. Appl Microbiol Biotechnol 86(6):1887-94
Rivera-Ruiz ME, et al.  (2010) Post-transcriptional regulation in the myo1Delta mutant of Saccharomyces cerevisiae. BMC Genomics 11():690
Staschke KA, et al.  (2010) Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast. J Biol Chem 285(22):16893-911
Zaborske JM, et al.  (2010) Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae. BMC Biochem 11():29
Almeida B, et al.  (2009) Yeast protein expression profile during acetic acid-induced apoptosis indicates causal involvement of the TOR pathway. Proteomics 9(3):720-32
Deplazes A, et al.  (2009) Yeast Uri1p promotes translation initiation and may provide a link to cotranslational quality control. EMBO J 28(10):1429-41
Garriz A, et al.  (2009) A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2. Mol Cell Biol 29(6):1592-607
Grousl T, et al.  (2009) Robust heat shock induces eIF2{alpha}-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae. J Cell Sci 122(Pt 12):2078-88
Madeo F, et al.  (2009) Phylogenetic conservation of the preapoptotic calreticulin exposure pathway from yeast to mammals. Cell Cycle 8(4):639-42