FUM1/YPL262W Literature Guide Help

Other names published for FUM1: fumarase FUM1, YPL262W

FUM1 - Mutants/Phenotypes (25)

ReferenceOther Genes Addressed
Yibmantasiri P, et al.  (2012) Molecular basis for fungicidal action of neothyonidioside, a triterpene glycoside from the sea cucumber, Australostichopus mollis. Mol Biosyst 8(3):902-12
Yoshida S and Yokoyama A  (2012) Identification and characterization of genes related to the production of organic acids in yeast. J Biosci Bioeng 113(5):556-61
Lee YJ, et al.  (2011) Phosphate and succinate use different mechanisms to inhibit sugar-induced cell death in yeast: insight into the Crabtree effect. J Biol Chem 286(23):20267-74
Lee YJ, et al.  (2011) TCA cycle-independent acetate metabolism via the glyoxylate cycle in Saccharomyces cerevisiae. Yeast 28(2):153-66
Lin AP, et al.  (2011) Effects of excess succinate and retrograde control of metabolite accumulation in yeast tricarboxylic cycle mutants. J Biol Chem 286(39):33737-46
Sun Z, et al.  (2011) Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS. PLoS Biol 9(4):e1000614
Mira NP, et al.  (2010) Genome-wide identification of Saccharomyces cerevisiae genes required for tolerance to acetic acid. Microb Cell Fact 9(1):79
Yogev O, et al.  (2010) Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response. PLoS Biol 8(3):e1000328
Kennedy CJ, et al.  (2009) Systems-level engineering of nonfermentative metabolism in yeast. Genetics 183(1):385-97
Regev-Rudzki N, et al.  (2008) The mitochondrial targeting sequence tilts the balance between mitochondrial and cytosolic dual localization. J Cell Sci 121(Pt 14):2423-31
Yogev O, et al.  (2007) Translation-coupled Translocation of Yeast Fumarase into Mitochondria in Vivo. J Biol Chem 282(40):29222-9
Kokko A, et al.  (2006) Modeling tumor predisposing FH mutations in yeast: effects on fumarase activity, growth phenotype and gene expression profile. Int J Cancer 118(6):1340-5
Blank LM, et al.  (2005) Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast. Genome Biol 6(6):R49
Romano JD and Kolter R  (2005) Pseudomonas-Saccharomyces interactions: influence of fungal metabolism on bacterial physiology and survival. J Bacteriol 187(3):940-8
McCammon MT, et al.  (2003) Global transcription analysis of Krebs tricarboxylic acid cycle mutants reveals an alternating pattern of gene expression and effects on hypoxic and oxidative genes. Mol Biol Cell 14(3):958-72
Sass E, et al.  (2003) Folding of fumarase during mitochondrial import determines its dual targeting in yeast. J Biol Chem 278(46):45109-16
Dimmer KS, et al.  (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53
Steinmetz LM, et al.  (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4
Sass E, et al.  (2001) Mitochondrial and cytosolic isoforms of yeast fumarase are derivatives of a single translation product and have identical amino termini. J Biol Chem 276(49):46111-7
Arikawa Y, et al.  (1999) Effect of gene disruptions of the TCA cycle on production of succinic acid in Saccharomyces cerevisiae. J Biosci Bioeng 87(1):28-36
Arikawa Y, et al.  (1999) Isolation of sake yeast strains possessing various levels of succinate- and/or malate-producing abilities by gene disruption or mutation. J Biosci Bioeng 87(3):333-9
Przybyla-Zawislak B, et al.  (1999) Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes. Genetics 152(1):153-66
Wu M, et al.  (1995) A single base-pair change (ATG-->ATC) nullifies the activity of cytosolic fumarase in Saccharomyces cerevisiae. Biochem Biophys Res Commun 215(2):578-90
Sulo P and Martin NC  (1993) Isolation and characterization of LIP5. A lipoate biosynthetic locus of Saccharomyces cerevisiae. J Biol Chem 268(23):17634-9
Wu M and Tzagoloff A  (1987) Mitochondrial and cytoplasmic fumarases in Saccharomyces cerevisiae are encoded by a single nuclear gene FUM1. J Biol Chem 262(25):12275-82