MET22/YOL064C Literature Guide Help

Other names published for MET22: HAL2, 3'(2')5'-bisphosphate nucleotidase, YOL064C

MET22 - Mutants/Phenotypes (32)

ReferenceOther Genes Addressed
Dewe JM, et al.  (2012) The yeast rapid tRNA decay pathway competes with elongation factor 1A for substrate tRNAs and acts on tRNAs lacking one or more of several modifications. RNA 18(10):1886-96
Bircham PW, et al.  (2011) Secretory pathway genes assessed by high-throughput microscopy and synthetic genetic array analysis. Mol Biosyst 7(9):2589-98
Chen H, et al.  (2011) A nucleotide metabolite controls stress-responsive gene expression and plant development. PLoS One 6(10):e26661
Fell GL, et al.  (2011) Identification of yeast genes involved in k homeostasis: loss of membrane traffic genes affects k uptake. G3 (Bethesda) 1(1):43-56
Wilusz JE, et al.  (2011) tRNAs marked with CCACCA are targeted for degradation. Science 334(6057):817-21
Cooper SJ, et al.  (2010) High-throughput profiling of amino acids in strains of the Saccharomyces cerevisiae deletion collection. Genome Res 20(9):1288-96
He X, et al.  (2010) Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks. Nat Genet 42(3):272-6
Lu SY, et al.  (2010) Molecular cloning of a cotton phosphatase gene and its functional characterization. Biochemistry (Mosc) 75(1):85-94
Ottosson LG, et al.  (2010) Sulfate Assimilation Mediates Tellurite Reduction and Toxicity in Saccharomyces cerevisiae. Eukaryot Cell 9(10):1635-1647
Fujii K, et al.  (2009) A role for ubiquitin in the clearance of nonfunctional rRNAs. Genes Dev 23(8):963-74
Chernyakov I, et al.  (2008) Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1. Genes Dev 22(10):1369-80
Vaupotic T, et al.  (2007) Novel 3'-phosphoadenosine-5'-phosphatases from extremely halotolerant Hortaea werneckii reveal insight into molecular determinants of salt tolerance of black yeasts. Fungal Genet Biol 44(11):1109-22
Freimoser FM, et al.  (2006) Systematic screening of polyphosphate (poly P) levels in yeast mutant cells reveals strong interdependence with primary metabolism. Genome Biol 7(11):R109
Dilda PJ, et al.  (2005) Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains. J Natl Cancer Inst 97(20):1539-47
Serviene E, et al.  (2005) Genome-wide screen identifies host genes affecting viral RNA recombination. Proc Natl Acad Sci U S A 102(30):10545-50
Spiegelberg BD, et al.  (2005) Alteration of lithium pharmacology through manipulation of phosphoadenosine phosphate metabolism. J Biol Chem 280(7):5400-5
Enyenihi AH and Saunders WS  (2003) Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163(1):47-54
Kushner DB, et al.  (2003) Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus. Proc Natl Acad Sci U S A 100(26):15764-9
Albert A, et al.  (2000) X-ray structure of yeast Hal2p, a major target of lithium and sodium toxicity, and identification of framework interactions determining cation sensitivity. J Mol Biol 295(4):927-38
Miyamoto R, et al.  (2000) Tol1, a fission yeast phosphomonoesterase, is an in vivo target of lithium, and its deletion leads to sulfite auxotrophy. J Bacteriol 182(13):3619-25
Lopez-Coronado JM, et al.  (1999) A novel mammalian lithium-sensitive enzyme with a dual enzymatic activity, 3'-phosphoadenosine 5'-phosphate phosphatase and inositol-polyphosphate 1-phosphatase. J Biol Chem 274(23):16034-9
de Nadal E, et al.  (1999) Biochemical and genetic analyses of the role of yeast casein kinase 2 in salt tolerance. J Bacteriol 181(20):6456-62
Bruning AR, et al.  (1998) Physiological and genetic characterisation of osmosensitive mutants of Saccharomyes cerevisiae. Arch Microbiol 170(2):99-105
Cherest H, et al.  (1997) Molecular characterization of two high affinity sulfate transporters in Saccharomyces cerevisiae. Genetics 145(3):627-35
Dichtl B, et al.  (1997) Lithium toxicity in yeast is due to the inhibition of RNA processing enzymes. EMBO J 16(23):7184-95
Murguia JR, et al.  (1996) The yeast HAL2 nucleotidase is an in vivo target of salt toxicity. J Biol Chem 271(46):29029-33
Quintero FJ, et al.  (1996) The SAL1 gene of Arabidopsis, encoding an enzyme with 3'(2'),5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase activities, increases salt tolerance in yeast. Plant Cell 8(3):529-37
Murguia JR, et al.  (1995) A salt-sensitive 3'(2'),5'-bisphosphate nucleotidase involved in sulfate activation. Science 267(5195):232-4
Peng Z and Verma DP  (1995) A rice HAL2-like gene encodes a Ca(2+)-sensitive 3'(2'),5'-diphosphonucleoside 3'(2')-phosphohydrolase and complements yeast met22 and Escherichia coli cysQ mutations. J Biol Chem 270(49):29105-10
Glaser HU, et al.  (1993) Salt tolerance and methionine biosynthesis in Saccharomyces cerevisiae involve a putative phosphatase gene. EMBO J 12(8):3105-10