TIM23/YNR017W Literature Guide Help

Other names published for TIM23: MIM23, MPI3, MAS6, YNR017W

TIM23 - Mutants/Phenotypes (27)

ReferenceOther Genes Addressed
Reinhold R, et al.  (2012) The channel-forming Sym1 protein is transported by the TIM23 complex in a presequence-independent manner. Mol Cell Biol 32(24):5009-21
Harner M, et al.  (2011) Lateral release of proteins from the TOM complex into the outer membrane of mitochondria. EMBO J 30(16):3232-41
Hasson SA, et al.  (2010) Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation. Proc Natl Acad Sci U S A 107(21):9578-83
Gevorkyan-Airapetov L, et al.  (2009) Interaction of Tim23 with Tim50 Is Essential for Protein Translocation by the Mitochondrial TIM23 Complex. J Biol Chem 284(8):4865-72
Tamura Y, et al.  (2009) Tim23-Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import. J Cell Biol 184(1):129-41
Alder NN, et al.  (2008) Fluorescence mapping of mitochondrial TIM23 complex reveals a water-facing, substrate-interacting helix surface. Cell 134(3):439-50
Alder NN, et al.  (2008) Quaternary structure of the mitochondrial TIM23 complex reveals dynamic association between Tim23p and other subunits. Mol Biol Cell 19(1):159-70
Breslow DK, et al.  (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8
Hwang DK, et al.  (2007) Tim54p connects inner membrane assembly and proteolytic pathways in the mitochondrion. J Cell Biol 178(7):1161-75
Peixoto PM, et al.  (2007) Awaking TIM22, a dynamic ligand-gated channel for protein insertion in the mitochondrial inner membrane. J Biol Chem 282(26):18694-701
van der Laan M, et al.  (2007) Motor-free mitochondrial presequence translocase drives membrane integration of preproteins. Nat Cell Biol 9(10):1152-9
Chacinska A, et al.  (2005) Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Cell 120(6):817-29
Tatsuta T, et al.  (2005) Formation of membrane-bound ring complexes by prohibitins in mitochondria. Mol Biol Cell 16(1):248-59
Burri L, et al.  (2004) Zim17, a novel zinc finger protein essential for protein import into mitochondria. J Biol Chem 279(48):50243-9
Murcha MW, et al.  (2003) Identification, expression, and import of components 17 and 23 of the inner mitochondrial membrane translocase from Arabidopsis. Plant Physiol 131(4):1737-47
Muro C, et al.  (2003) Comparison of the TIM and TOM channel activities of the mitochondrial protein import complexes. Biophys J 84(5):2981-9
Kawai A, et al.  (2001) Loss of the mitochondrial Hsp70 functions causes aggregation of mitochondria in yeast cells. J Cell Sci 114(Pt 19):3565-74
Milisav I, et al.  (2001) Modular structure of the TIM23 preprotein translocase of mitochondria. J Biol Chem 276(28):25856-61
Davis AJ, et al.  (2000) Two intermembrane space TIM complexes interact with different domains of Tim23p during its import into mitochondria. J Cell Biol 150(6):1271-82
Paschen SA, et al.  (2000) The role of the TIM8-13 complex in the import of Tim23 into mitochondria. EMBO J 19(23):6392-400
Arnold I, et al.  (1998) Two distinct and independent mitochondrial targeting signals function in the sorting of an inner membrane protein, cytochrome c1. J Biol Chem 273(3):1469-76
Davis AJ, et al.  (1998) Tim23p contains separate and distinct signals for targeting to mitochondria and insertion into the inner membrane. Mol Biol Cell 9(9):2577-93
Ryan KR, et al.  (1998) Characterization of the mitochondrial inner membrane translocase complex: the Tim23p hydrophobic domain interacts with Tim17p but not with other Tim23p molecules. Mol Cell Biol 18(1):178-87
Lohret TA, et al.  (1997) Tim23, a protein import component of the mitochondrial inner membrane, is required for normal activity of the multiple conductance channel, MCC. J Cell Biol 137(2):377-86
Blom J, et al.  (1995) Functional and physical interactions of components of the yeast mitochondrial inner-membrane import machinery (MIM). Eur J Biochem 232(1):309-14
Dekker PJ, et al.  (1993) Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane. FEBS Lett 330(1):66-70
Emtage JL and Jensen RE  (1993) MAS6 encodes an essential inner membrane component of the yeast mitochondrial protein import pathway. J Cell Biol 122(5):1003-12