CYB2/YML054C Literature Guide Help

Other names published for CYB2: FCB2, YML054C

CYB2 - Mutants/Phenotypes (21)

ReferenceOther Genes Addressed
Hewitt VL, et al.  (2012) A model system for mitochondrial biogenesis reveals evolutionary rewiring of protein import and membrane assembly pathways. Proc Natl Acad Sci U S A 109(49):E3358-66
Sauer M, et al.  (2010) 16 years research on lactic acid production with yeast - ready for the market? Biotechnol Genet Eng Rev 27():229-56
Abbott DA, et al.  (2009) Catalase overexpression reduces lactic acid-induced oxidative stress in Saccharomyces cerevisiae. Appl Environ Microbiol 75(8):2320-5
Ookubo A, et al.  (2008) Improvement of L-Lactate Production by CYB2 Gene Disruption in a Recombinant Saccharomyces cerevisiae Strain under Low pH Condition. Biosci Biotechnol Biochem 72(11):3063-6
Velagapudi VR, et al.  (2007) Metabolic flux screening of Saccharomyces cerevisiae single knockout strains on glucose and galactose supports elucidation of gene function. J Biotechnol 132(4):395-404
Luo W, et al.  (2006) Substrate specificity of inner membrane peptidase in yeast mitochondria. Mol Genet Genomics 275(5):431-6
Mowat CG, et al.  (2004) Altered substrate specificity in flavocytochrome b2: structural insights into the mechanism of L-lactate dehydrogenation. Biochemistry 43(29):9519-26
Sobrado P and Fitzpatrick PF  (2003) Solvent and primary deuterium isotope effects show that lactate CH and OH bond cleavages are concerted in Y254F flavocytochrome b2, consistent with a hydride transfer mechanism. Biochemistry 42(51):15208-14
Cunane LM, et al.  (2002) Crystallographic study of the recombinant flavin-binding domain of Baker's yeast flavocytochrome b(2): comparison with the intact wild-type enzyme. Biochemistry 41(13):4264-72
Gondry M, et al.  (2001) The catalytic role of tyrosine 254 in flavocytochrome b2 (L-lactate dehydrogenase from baker's yeast). Comparison between the Y254F and Y254L mutant proteins. Eur J Biochem 268(18):4918-27
Sobrado P, et al.  (2001) Probing the relative timing of hydrogen abstraction steps in the flavocytochrome b2 reaction with primary and solvent deuterium isotope effects and mutant enzymes. Biochemistry 40(4):994-1001
Geissler A, et al.  (2000) Membrane potential-driven protein import into mitochondria. The sorting sequence of cytochrome b(2) modulates the deltapsi-dependence of translocation of the matrix-targeting sequence. Mol Biol Cell 11(11):3977-91
Mowat CG, et al.  (2000) Changing the heme ligation in flavocytochrome b2: substitution of histidine-66 by cysteine. J Biol Inorg Chem 5(5):584-92
Mowat CG, et al.  (2000) Kinetic and crystallographic studies on the active site Arg289Lys mutant of flavocytochrome b2 (yeast L-lactate dehydrogenase). Biochemistry 39(12):3266-75
Chen X, et al.  (1999) Signal peptides having standard and nonstandard cleavage sites can be processed by Imp1p of the mitochondrial inner membrane protease. J Biol Chem 274(53):37750-4
Lodi T, et al.  (1994) Carbon catabolite repression in Kluyveromyces lactis: isolation and characterization of the KIDLD gene encoding the mitochondrial enzyme D-lactate ferricytochrome c oxidoreductase. Mol Gen Genet 244(6):622-9
Glick BS, et al.  (1993) Import of cytochrome b2 to the mitochondrial intermembrane space: the tightly folded heme-binding domain makes import dependent upon matrix ATP. Protein Sci 2(11):1901-17
Lodi T and Ferrero I  (1993) Isolation of the DLD gene of Saccharomyces cerevisiae encoding the mitochondrial enzyme D-lactate ferricytochrome c oxidoreductase. Mol Gen Genet 238(3):315-24
Schwarz E, et al.  (1993) Targeting of cytochrome b2 into the mitochondrial intermembrane space: specific recognition of the sorting signal. EMBO J 12(6):2295-302
Rush K, et al.  (1986) Null and electrophoretic mobility mutants in the structural gene for L-lactate dehydrogenase of Saccharomyces cerevisiae. FEBS Lett 198(1):89-91
Guiard B  (1985) Structure, expression and regulation of a nuclear gene encoding a mitochondrial protein: the yeast L(+)-lactate cytochrome c oxidoreductase (cytochrome b2). EMBO J 4(12):3265-72