UNG1/YML021C Literature Guide Help

Other names published for UNG1: YML021C

UNG1 - Mutants/Phenotypes (30)

ReferenceOther Genes Addressed
Chen X, et al.  (2012) Nucleosomes suppress spontaneous mutations base-specifically in eukaryotes. Science 335(6073):1235-8
Collura A, et al.  (2012) Abasic sites linked to dUTP incorporation in DNA are a major cause of spontaneous mutations in absence of base excision repair and Rad17-Mec3-Ddc1 (9-1-1) DNA damage checkpoint clamp in Saccharomyces cerevisiae. DNA Repair (Amst) 11(3):294-303
Haruta N, et al.  (2012) Chronic low-dose ultraviolet-induced mutagenesis in nucleotide excision repair-deficient cells. Nucleic Acids Res 40(17):8406-15
Lada AG, et al.  (2011) Mutator effects and mutation signatures of editing deaminases produced in bacteria and yeast. Biochemistry (Mosc) 76(1):131-46
Ruiz JF, et al.  (2011) AID Induces Double-Strand Breaks at Immunoglobulin Switch Regions and c-MYC Causing Chromosomal Translocations in Yeast THO Mutants. PLoS Genet 7(2):e1002009
Kim N and Jinks-Robertson S  (2010) Abasic sites in the transcribed strand of yeast DNA are removed by transcription-coupled nucleotide excision repair. Mol Cell Biol 30(13):3206-15
Matuo R, et al.  (2010) DNA repair pathways involved in repair of lesions induced by 5-fluorouracil and its active metabolite FdUMP. Biochem Pharmacol 79(2):147-53
Northam MR, et al.  (2010) Participation of DNA polymerase {zeta} in replication of undamaged DNA in Saccharomyces cerevisiae. Genetics 184(1):27-42
Chien CY, et al.  (2009) Ung1p-mediated uracil-base excision repair in mitochondria is responsible for the petite formation in thymidylate deficient yeast. FEBS Lett 583(9):1499-504
Kim N and Jinks-Robertson S  (2009) dUTP incorporation into genomic DNA is linked to transcription in yeast. Nature 459(7250):1150-3
Sikdar N, et al.  (2008) Spt2p Defines a New Transcription-Dependent Gross Chromosomal Rearrangement Pathway. PLoS Genet 4(12):e1000290
Hoskins J and Scott Butler J  (2007) Evidence for distinct DNA- and RNA-based mechanisms of 5-fluorouracil cytotoxicity in Saccharomyces cerevisiae. Yeast 24(10):861-70
Kanellis P, et al.  (2007) A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions. PLoS Genet 3(8):e134
Kiakos K, et al.  (2007) DNA sequence selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145. Mol Cancer Ther 6(10):2708-18
Lucaccioni A, et al.  (2007) High rate of starvation-associated mutagenesis in Ung(-) yeast caused by the overproduction of human activation-induced deaminase. Curr Genet 52(5-6):239-45
Allen BG, et al.  (2006) Base excision repair of both uracil and oxidatively damaged bases contribute to thymidine deprivation-induced radiosensitization. Int J Radiat Oncol Biol Phys 65(5):1544-52
Boiteux S and Guillet M  (2006) Use of yeast for detection of endogenous abasic lesions, their source, and their repair. Methods Enzymol 408:79-91
Guillet M, et al.  (2006) dUTPase activity is critical to maintain genetic stability in Saccharomyces cerevisiae. Nucleic Acids Res 34(7):2056-66
Seiple L, et al.  (2006) Linking uracil base excision repair and 5-fluorouracil toxicity in yeast. Nucleic Acids Res 34(1):140-51
Dornfeld K and Johnson M  (2005) AP endonuclease deficiency results in extreme sensitivity to thymidine deprivation. Nucleic Acids Res 33(20):6644-53
Karumbati AS and Wilson TE  (2005) Abrogation of the Chk1-Pds1 checkpoint leads to tolerance of persistent single-strand breaks in Saccharomyces cerevisiae. Genetics 169(4):1833-44
Elateri I, et al.  (2003) hSMUG1 can functionally compensate for Ung1 in the yeast Saccharomyces cerevisiae. DNA Repair (Amst) 2(3):315-23
Guillet M and Boiteux S  (2003) Origin of endogenous DNA abasic sites in Saccharomyces cerevisiae. Mol Cell Biol 23(22):8386-94
Tinkelenberg BA, et al.  (2002) dUTPase and uracil-DNA glycosylase are central modulators of antifolate toxicity in Saccharomyces cerevisiae. Cancer Res 62(17):4909-15
Chatterjee A and Singh KK  (2001) Uracil-DNA glycosylase-deficient yeast exhibit a mitochondrial mutator phenotype. Nucleic Acids Res 29(24):4935-40
Morey NJ, et al.  (2000) Genetic analysis of transcription-associated mutation in Saccharomyces cerevisiae. Genetics 154(1):109-20
Gadsden MH, et al.  (1993) dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae. EMBO J 12(11):4425-31
Impellizzeri KJ, et al.  (1991) The spectrum of spontaneous mutations in a Saccharomyces cerevisiae uracil-DNA-glycosylase mutant limits the function of this enzyme to cytosine deamination repair. J Bacteriol 173(21):6807-10
Percival KJ, et al.  (1989) Molecular cloning and primary structure of the uracil-DNA-glycosylase gene from Saccharomyces cerevisiae. J Biol Chem 264(5):2593-8
Burgers PM and Klein MB  (1986) Selection by genetic transformation of a Saccharomyces cerevisiae mutant defective for the nuclear uracil-DNA-glycosylase. J Bacteriol 166(3):905-13