GCN1/YGL195W Literature Guide Help

Other names published for GCN1: NDR1, AAS103, YGL195W

GCN1 - Mutants/Phenotypes (24)

ReferenceOther Genes Addressed
Granek JA, et al.  (2013) The Genetic Architecture of Biofilm Formation in a Clinical Isolate of Saccharomyces cerevisiae. Genetics 193(2):587-600
Visweswaraiah J, et al.  (2012) Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation. J Biol Chem 287(45):37757-68
Waller T, et al.  (2012) Evidence that Yih1 resides in a complex with ribosomes. FEBS J 279(10):1761-76
Sattlegger E, et al.  (2011) Gcn1 and Actin Binding to Yih1: IMPLICATIONS FOR ACTIVATION OF THE eIF2 KINASE GCN2. J Biol Chem 286(12):10341-55
McCue PP and Phang JM  (2008) Identification of Human Intracellular Targets of the Medicinal Herb St. John's Wort by Chemical-Genetic Profiling in Yeast. J Agric Food Chem 56(22):11011-11017
Steffensen L and Pedersen PA  (2006) Heterologous expression of membrane and soluble proteins derepresses GCN4 mRNA translation in the yeast Saccharomyces cerevisiae. Eukaryot Cell 5(2):248-61
Pereira CM, et al.  (2005) IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. J Biol Chem 280(31):28316-23
Sattlegger E and Hinnebusch AG  (2005) Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation. J Biol Chem 280(16):16514-21
Goossens A, et al.  (2001) The protein kinase Gcn2p mediates sodium toxicity in yeast. J Biol Chem 276(33):30753-60
Kubota H, et al.  (2001) Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2. J Biol Chem 276(20):17591-6
Garcia-Barrio M, et al.  (2000) Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation. EMBO J 19(8):1887-99
Sattlegger E and Hinnebusch AG  (2000) Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells. EMBO J 19(23):6622-33
Sood R, et al.  (2000) A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha. Genetics 154(2):787-801
Marton MJ, et al.  (1993) GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2. Mol Cell Biol 13(6):3541-56
Rolfes RJ and Hinnebusch AG  (1993) Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2. Mol Cell Biol 13(8):5099-111
Ramirez M, et al.  (1992) Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases. Mol Cell Biol 12(12):5801-15
Cigan AM, et al.  (1991) Complex formation by positive and negative translational regulators of GCN4. Mol Cell Biol 11(6):3217-28
Moehle CM and Hinnebusch AG  (1991) Association of RAP1 binding sites with stringent control of ribosomal protein gene transcription in Saccharomyces cerevisiae. Mol Cell Biol 11(5):2723-35
Hannig EM, et al.  (1990) The translational activator GCN3 functions downstream from GCN1 and GCN2 in the regulatory pathway that couples GCN4 expression to amino acid availability in Saccharomyces cerevisiae. Genetics 126(3):549-62
Messenguy F and Scherens B  (1990) Induction of "General Control" and thermotolerance in cdc mutants of Saccharomyces cerevisiae. Mol Gen Genet 224(2):257-63
Briza P, et al.  (1986) Dityrosine is a prominent component of the yeast ascospore wall. A proof of its structure. J Biol Chem 261(9):4288-94
Myers PL, et al.  (1986) Negative regulatory gene for general control of amino acid biosynthesis in Saccharomyces cerevisiae. Mol Cell Biol 6(9):3150-5
Niederberger P, et al.  (1986) Identification and characterization of four new GCD genes in Saccharomyces cerevisiae. Curr Genet 10(9):657-64
Skvirsky RC, et al.  (1986) A new negative control gene for amino acid biosynthesis in Saccharomyces cerevisiae. Curr Genet 10(7):495-501