CUP2/YGL166W Literature Guide Help

Other names published for CUP2: ACE1, YGL166W

CUP2 - Mutants/Phenotypes (29)

ReferenceOther Genes Addressed
Blackman RK, et al.  (2012) Mitochondrial electron transport is the cellular target of the oncology drug elesclomol. PLoS One 7(1):e29798
Wimalarathna RN, et al.  (2012) Chromatin repositioning activity and transcription machinery are both recruited by Ace1p in yeast CUP1 activation. Biochem Biophys Res Commun 422(4):658-63
Mu P, et al.  (2011) Cu2+ triggers reversible aggregation of a disordered His-rich dehydrin MpDhn12 from Musa paradisiaca. J Biochem 150(5):491-9
Reeder NL, et al.  (2011) Zinc pyrithione inhibits yeast growth through copper influx and inactivation of iron-sulfur proteins. Antimicrob Agents Chemother 55(12):5753-60
Ishizaki H, et al.  (2010) Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation. Dis Model Mech 3(9-10):639-51
Song M, et al.  (2009) Discrete dynamical system modelling for gene regulatory networks of 5-hydroxymethylfurfural tolerance for ethanologenic yeast. IET Syst Biol 3(3):203
Chen X, et al.  (2008) Copper sensing function of Drosophila metal-responsive transcription factor-1 is mediated by a tetranuclear Cu(I) cluster. Nucleic Acids Res 36(9):3128-38
Jin YH, et al.  (2008) Global transcriptome and deletome profiles of yeast exposed to transition metals. PLoS Genet 4(4):e1000053
Serero A, et al.  (2008) Yeast genes involved in cadmium tolerance: Identification of DNA replication as a target of cadmium toxicity. DNA Repair (Amst) 7(8):1262-75
Rustici G, et al.  (2007) Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study. Genome Biol 8(5):R73
Chua G, et al.  (2006) Identifying transcription factor functions and targets by phenotypic activation. Proc Natl Acad Sci U S A 103(32):12045-50
Polanco R, et al.  (2006) Cloning and functional characterization of the gene encoding the transcription factor Acel in the basidiomycete Phanerochaete chrysosporium. Biol Res 39(4):641-8
Gomes DS, et al.  (2005) Evaluation of the role of Ace1 and Yap1 in cadmium absorption using the eukaryotic cell model Saccharomyces cerevisiae. Environ Toxicol Pharmacol 20(3):383-9
Keller G, et al.  (2005) Independent metalloregulation of Ace1 and Mac1 in Saccharomyces cerevisiae. Eukaryot Cell 4(11):1863-71
van Bakel H, et al.  (2005) Gene expression profiling and phenotype analyses of S. cerevisiae in response to changing copper reveals six genes with new roles in copper and iron metabolism. Physiol Genomics 22(3):356-67
Laliberte J, et al.  (2004) The Schizosaccharomyces pombe Pccs protein functions in both copper trafficking and metal detoxification pathways. J Biol Chem 279(27):28744-55
Oki M, et al.  (2004) Barrier proteins remodel and modify chromatin to restrict silenced domains. Mol Cell Biol 24(5):1956-67
Ohashi K, et al.  (2003) Copper(II) protects yeast against the toxicity of cisplatin independently of the induction of metallothionein and the inhibition of platinum uptake. Biochem Biophys Res Commun 310(1):148-152
Keller G, et al.  (2001) Haa1, a protein homologous to the copper-regulated transcription factor Ace1, is a novel transcriptional activator. J Biol Chem 276(42):38697-702
Tohoyama H, et al.  (2001) Induction for the expression of yeast metallothionein gene, CUP1, by cobalt. Microbios 104(408):99-104
Lee DK, et al.  (1999) Different upstream transcriptional activators have distinct coactivator requirements. Genes Dev 13(22):2934-9
Dobi A, et al.  (1995) Distinct regions of Cu(I).ACE1 contact two spatially resolved DNA major groove sites. J Biol Chem 270(17):10171-8
Butler G and Thiele DJ  (1991) ACE2, an activator of yeast metallothionein expression which is homologous to SWI5. Mol Cell Biol 11(1):476-85
Carri MT, et al.  (1991) Evidence for co-regulation of Cu,Zn superoxide dismutase and metallothionein gene expression in yeast through transcriptional control by copper via the ACE 1 factor. FEBS Lett 278(2):263-6
Buchman C, et al.  (1990) A single amino acid change in CUP2 alters its mode of DNA binding. Mol Cell Biol 10(9):4778-87
Hu S, et al.  (1990) The DNA and Cu binding functions of ACE1 are interdigitated within a single domain. New Biol 2(6):544-55
Buchman C, et al.  (1989) The CUP2 gene product, regulator of yeast metallothionein expression, is a copper-activated DNA-binding protein. Mol Cell Biol 9(9):4091-5
Welch J, et al.  (1989) The CUP2 gene product regulates the expression of the CUP1 gene, coding for yeast metallothionein. EMBO J 8(1):255-60
Thiele DJ  (1988) ACE1 regulates expression of the Saccharomyces cerevisiae metallothionein gene. Mol Cell Biol 8(7):2745-52