PNC1/YGL037C Literature Guide Help

Other names published for PNC1: nicotinamidase, YGL037C

PNC1 - Mutants/Phenotypes (27)

ReferenceOther Genes Addressed
Smith BC, et al.  (2012) Structural and Kinetic Isotope Effect Studies of Nicotinamidase (Pnc1) from Saccharomyces cerevisiae. Biochemistry 51(1):243-56
Tripathi K, et al.  (2012) Nicotinamide induces Fob1-dependent plasmid integration into chromosome XII in Saccharomyces cerevisiae. FEMS Yeast Res 12(8):949-57
Belenky P, et al.  (2011) Nrt1 and Tna1-Independent Export of NAD Precursor Vitamins Promotes NAD Homeostasis and Allows Engineering of Vitamin Production. PLoS One 6(5):e19710
Caballero A, et al.  (2011) Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing. Mol Cell 42(3):390-400
Ha CW and Huh WK  (2011) Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae. Nucleic Acids Res 39(4):1336-50
Vendrell A, et al.  (2011) Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase.LID - 10.1038/embor.2011.154 [doi] EMBO Rep ()
Jimenez A, et al.  (2010) The biological activity of the wine anthocyanins delphinidin and petunidin is mediated through Msn2 and Msn4 in Saccharomyces cerevisiae. FEMS Yeast Res 10(7):858-69
Li M, et al.  (2010) Thiamine Biosynthesis in Saccharomyces cerevisiae Is Regulated by the NAD+-Dependent Histone Deacetylase Hst1. Mol Cell Biol 30(13):3329-41
Minard KI and McAlister-Henn L  (2010) Pnc1p Supports Increases in Cellular NAD(H) Levels in Response to Internal or External Oxidative Stress. Biochemistry 49(30):6299-301
Lu SP, et al.  (2009) Assimilation of Endogenous Nicotinamide Riboside Is Essential for Calorie Restriction-mediated Life Span Extension in Saccharomyces cerevisiae. J Biol Chem 284(25):17110-9
Minard KI and McAlister-Henn L  (2009) Redox responses in yeast to acetate as the carbon source. Arch Biochem Biophys 483(1):136-43
Postma L, et al.  (2009) Surviving in the cold: yeast mutants with extended hibernating lifespan are oxidant sensitive. Aging (Albany NY) 1(11):957-60
McClure JM, et al.  (2008) Pnc1p-Mediated Nicotinamide Clearance Modifies the Epigenetic Properties of rDNA Silencing in Saccharomyces cerevisiae. Genetics 180(2):797-810
Belenky P, et al.  (2007) Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. Cell 129(3):473-84
Medvedik O, et al.  (2007) MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol 5(10):e261
Smith DL Jr, et al.  (2007) Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins. Aging Cell 6(5):649-62
Tahara EB, et al.  (2007) Dihydrolipoyl dehydrogenase as a source of reactive oxygen species inhibited by caloric restriction and involved in Saccharomyces cerevisiae aging. FASEB J 21(1):274-83
Sauve AA, et al.  (2005) Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition. Mol Cell 17(4):595-601
Couzin J  (2004) Scientific community. Aging research's family feud. Science 303(5662):1276-9
Gallo CM, et al.  (2004) Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity. Mol Cell Biol 24(3):1301-12
Koc A, et al.  (2004) Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging. Proc Natl Acad Sci U S A 101(21):7999-8004
Lin SJ, et al.  (2004) Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev 18(1):12-6
Martinez MJ, et al.  (2004) Genomic analysis of stationary-phase and exit in Saccharomyces cerevisiae: gene expression and identification of novel essential genes. Mol Biol Cell 15(12):5295-305
Anderson RM, et al.  (2003) Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423(6936):181-5
Anderson RM, et al.  (2002) Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. J Biol Chem 277(21):18881-90
Ghislain M, et al.  (2002) Identification and functional analysis of the Saccharomyces cerevisiae nicotinamidase gene, PNC1. Yeast 19(3):215-24
Sandmeier JJ, et al.  (2002) Telomeric and rDNA silencing in Saccharomyces cerevisiae are dependent on a nuclear NAD(+) salvage pathway. Genetics 160(3):877-89