SCS2/YER120W Literature Guide Help

Other names published for SCS2: YER120W

SCS2 - Mutants/Phenotypes (27)

ReferenceOther Genes Addressed
Felberbaum R, et al.  (2012) Desumoylation of the endoplasmic reticulum membrane VAP family protein Scs2 by Ulp1 and SUMO regulation of the inositol synthesis pathway. Mol Cell Biol 32(1):64-75
Fundakowski J, et al.  (2012) Localization of a Subset of Yeast mRNAs Depends on Inheritance of Endoplasmic Reticulum. Traffic 13(12):1642-52
Yibmantasiri P, et al.  (2012) Molecular basis for fungicidal action of neothyonidioside, a triterpene glycoside from the sea cucumber, Australostichopus mollis. Mol Biosyst 8(3):902-12
Bircham PW, et al.  (2011) Secretory pathway genes assessed by high-throughput microscopy and synthetic genetic array analysis. Mol Biosyst 7(9):2589-98
Nakamichi S, et al.  (2011) Human VAPA and the yeast VAP Scs2p with an altered proline distribution can phenocopy amyotrophic lateral sclerosis-associated VAPB(P56S). Biochem Biophys Res Commun 404(2):605-9
Stefan CJ, et al.  (2011) Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites. Cell 144(3):389-401
Villa-Garcia MJ, et al.  (2011) Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling. Mol Genet Genomics 285(2):125-49
Wilson JD, et al.  (2011) Yet1p-Yet3p interacts with Scs2p-Opi1p to regulate ER localization of the Opi1p repressor. Mol Biol Cell 22(9):1430-9
Young BP, et al.  (2010) Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism. Science 329(5995):1085-8
Fernandez-Murray JP, et al.  (2009) NTE1-encoded phosphatidylcholine phospholipase b regulates transcription of phospholipid biosynthetic genes. J Biol Chem 284(52):36034-46
Li Z, et al.  (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7(10):e1000213
Zou J, et al.  (2009) Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin-dependent kinases in Saccharomyces cerevisiae. Mol Biol Cell 20(14):3239-50
Kagiwada S and Hashimoto M  (2007) The yeast VAP homolog Scs2p has a phosphoinositide-binding ability that is correlated with its activity. Biochem Biophys Res Commun 364(4):870-6
Loewen CJ, et al.  (2007) Inheritance of cortical ER in yeast is required for normal septin organization. J Cell Biol 179(3):467-83
Cowen LE and Lindquist S  (2005) Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science 309(5744):2185-9
Kaiser SE, et al.  (2005) Structural basis of FFAT motif-mediated ER targeting. Structure 13(7):1035-45
Loewen CJ and Levine TP  (2005) A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins. J Biol Chem 280(14):14097-104
Brickner JH and Walter P  (2004) Gene recruitment of the activated INO1 locus to the nuclear membrane. PLoS Biol 2(11):e342
Loewen CJ, et al.  (2004) Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid. Science 304(5677):1644-7
Anderson JB, et al.  (2003) Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae. Genetics 163(4):1287-98
Kagiwada S and Zen R  (2003) Role of the yeast VAP homolog, Scs2p, in INO1 expression and phospholipid metabolism. J Biochem 133(4):515-22
Kushner DB, et al.  (2003) Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus. Proc Natl Acad Sci U S A 100(26):15764-9
Loewen CJ, et al.  (2003) A conserved ER targeting motif in three families of lipid binding proteins and in Opi1p binds VAP. EMBO J 22(9):2025-35
Cuperus G and Shore D  (2002) Restoration of silencing in Saccharomyces cerevisiae by tethering of a novel Sir2-interacting protein, Esc8. Genetics 162(2):633-45
Craven RJ and Petes TD  (2001) The Saccharomyces cerevisiae suppressor of choline sensitivity (SCS2) gene is a multicopy Suppressor of mec1 telomeric silencing defects. Genetics 158(1):145-54
Kagiwada S, et al.  (1998) The Saccharomyces cerevisiae SCS2 gene product, a homolog of a synaptobrevin-associated protein, is an integral membrane protein of the endoplasmic reticulum and is required for inositol metabolism. J Bacteriol 180(7):1700-8
Nikawa J, et al.  (1995) Cloning and sequence of the SCS2 gene, which can suppress the defect of INO1 expression in an inositol auxotrophic mutant of Saccharomyces cerevisiae. J Biochem 118(1):39-45