ISC1/YER019W Literature Guide Help

Other names published for ISC1: inositol phosphosphingolipid phospholipase, YER019W

ISC1 - Mutants/Phenotypes (30)

ReferenceOther Genes Addressed
Barbosa AD, et al.  (2012) Activation of the Hog1p kinase in Isc1p-deficient yeast cells is associated with mitochondrial dysfunction, oxidative stress sensitivity and premature aging. Mech Ageing Dev 133(5):317-30
Short MK, et al.  (2012) The yeast magmas ortholog pam16 has an essential function in fermentative growth that involves sphingolipid metabolism. PLoS One 7(7):e39428
Tripathi K, et al.  (2012) Hydroxyurea treatment inhibits proliferation of Cryptococcus neoformans in mice. Front Microbiol 3():187
Tripathi K, et al.  (2012) Nicotinamide induces Fob1-dependent plasmid integration into chromosome XII in Saccharomyces cerevisiae. FEMS Yeast Res 12(8):949-57
Barbosa AD, et al.  (2011) Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells. Mol Microbiol 81(2):515-27
Ishiwata-Kimata Y, et al.  (2011) Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways. Mol Biol Cell 22(18):3520-32
Lee YJ, et al.  (2011) Defects in very long chain Fatty Acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease. PLoS One 6(1):e15946
North M, et al.  (2011) Genome-wide functional profiling reveals genes required for tolerance to benzene metabolites in yeast. PLoS One 6(8):e24205
Tripathi K, et al.  (2011) Cellular morphogenesis under stress is influenced by the sphingolipid pathway gene ISC1 and DNA integrity checkpoint genes in Saccharomyces cerevisiae. Genetics 189(2):533-47
Usher J, et al.  (2011) Chemical and Synthetic Genetic Array Analysis Identifies Genes that Suppress Xylose Utilization and Fermentation in Saccharomyces cerevisiae. G3 (Bethesda) 1(4):247-58
Wu BX, et al.  (2011) Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference. J Biol Chem 286(25):22362-71
Guan XL, et al.  (2009) Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology. Mol Biol Cell 20(7):2083-95
Kitagaki H, et al.  (2009) ISC1-dependent Metabolic Adaptation Reveals an Indispensable Role for Mitochondria in Induction of Nuclear Genes during the Diauxic Shift in Saccharomyces cerevisiae. J Biol Chem 284(16):10818-30
Matmati N, et al.  (2009) Hydroxyurea Sensitivity Reveals a Role for ISC1 in the Regulation of G2/M. J Biol Chem 284(13):8241-6
Muccioli GG, et al.  (2009) Genetic manipulation of palmitoylethanolamide production and inactivation in Saccharomyces cerevisiae. PLoS One 4(6):e5942
Almeida T, et al.  (2008) Isc1p Plays a Key Role in Hydrogen Peroxide Resistance and Chronological Lifespan through Modulation of Iron Levels and Apoptosis. Mol Biol Cell 19(3):865-876
Mousley CJ, et al.  (2008) Trans-Golgi network and endosome dynamics connect ceramide homeostasis with regulation of the unfolded protein response and TOR signaling in yeast. Mol Biol Cell 19(11):4785-803
Wilder AJ and Cowart LA  (2008) A systems approach demonstrating sphingolipid-dependent transcription in stress responses. Methods Mol Biol 477:369-81
Kitagaki H, et al.  (2007) Isc1 regulates sphingolipid metabolism in yeast mitochondria. Biochim Biophys Acta 1768(11):2849-61
Cowart LA, et al.  (2006) Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae. Biochem J 393(Pt 3):733-40
Tabuchi M, et al.  (2006) The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Mol Cell Biol 26(15):5861-75
Gaigg B, et al.  (2005) Synthesis of sphingolipids with very long chain fatty acids but not ergosterol is required for routing of newly synthesized plasma membrane ATPase to the cell surface of yeast. J Biol Chem 280(23):22515-22
Vaena de Avalos S, et al.  (2005) The phosphatidylglycerol/cardiolipin biosynthetic pathway is required for the activation of inositol phosphosphingolipid phospholipase C, Isc1p, during growth of Saccharomyces cerevisiae. J Biol Chem 280(8):7170-7
Lawrence CL, et al.  (2004) Evidence of a new role for the high-osmolarity glycerol mitogen-activated protein kinase pathway in yeast: regulating adaptation to citric acid stress. Mol Cell Biol 24(8):3307-23
Vaena de Avalos S, et al.  (2004) Activation and localization of inositol phosphosphingolipid phospholipase C, Isc1p, to the mitochondria during growth of Saccharomyces cerevisiae. J Biol Chem 279(12):11537-45
Okamoto Y, et al.  (2003) Functional analysis of ISC1 by site-directed mutagenesis. Biochemistry 42(25):7855-62
Betz C, et al.  (2002) ISC1-encoded inositol phosphosphingolipid phospholipase C is involved in Na+/Li+ halotolerance of Saccharomyces cerevisiae. Eur J Biochem 269(16):4033-9
Chang M, et al.  (2002) A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A 99(26):16934-9
Okamoto Y, et al.  (2002) Structural requirements for selective binding of ISC1 to anionic phospholipids. J Biol Chem 277(48):46470-7
Sawai H, et al.  (2000) Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae. J Biol Chem 275(50):39793-8