GCN4/YEL009C Literature Guide Help

Other names published for GCN4: AAS3, ARG9, AAS101, YEL009C

GCN4 - Mutants/Phenotypes (209)

ReferenceOther Genes Addressed
Rubin-Bejerano I, et al.  (2003) Phagocytosis by neutrophils induces an amino acid deprivation response in Saccharomyces cerevisiae and Candida albicans. Proc Natl Acad Sci U S A 100(19):11007-12
Sosa E, et al.  (2003) Gcn4 negatively regulates expression of genes subjected to nitrogen catabolite repression. Biochem Biophys Res Commun 310(4):1175-80
Wang X, et al.  (2003) Thermodynamic characterization of the folding coupled DNA binding by the monomeric transcription activator GCN4 peptide. Biophys J 84(3):1867-75
Yu Q, et al.  (2003) Rap1p and other transcriptional regulators can function in defining distinct domains of gene expression. Nucleic Acids Res 31(4):1224-33
Bird GH and Shin JA  (2002) MALDI-TOF mass spectrometry characterization of recombinant hydrophobic mutants containing the GCN4 basic region/leucine zipper motif. Biochim Biophys Acta 1597(2):252-9
Hardwidge PR, et al.  (2002) Dominant effect of protein charge rather than protein shape in apparent DNA bending by engineered bZIP domains. Biochemistry 41(26):8277-88
Hollenbeck JJ, et al.  (2002) The role of helix stabilizing residues in GCN4 basic region folding and DNA binding. Protein Sci 11(11):2740-7
Knappenberger JA, et al.  (2002) A buried polar residue in the hydrophobic interface of the coiled-coil peptide, GCN4-p1, plays a thermodynamic, not a kinetic role in folding. J Mol Biol 321(1):1-6
Abdullah MF and Borts RH  (2001) Meiotic recombination frequencies are affected by nutritional states in Saccharomycescerevisiae. Proc Natl Acad Sci U S A 98(25):14524-9
Goossens A, et al.  (2001) The protein kinase Gcn2p mediates sodium toxicity in yeast. J Biol Chem 276(33):30753-60
Hollenbeck JJ, et al.  (2001) A GCN4 variant with a C-terminal basic region binds to DNA with wild-type affinity. Biochemistry 40(46):13833-9
Kammerer RA, et al.  (2001) An intrahelical salt bridge within the trigger site stabilizes the GCN4 leucine zipper. J Biol Chem 276(17):13685-8
Natarajan K, et al.  (2001) Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Mol Cell Biol 21(13):4347-68
Pascual-Ahuir A, et al.  (2001) The Sko1p repressor and Gcn4p activator antagonistically modulate stress-regulated transcription in Saccharomyces cerevisiae. Mol Cell Biol 21(1):16-25
Stevenson LF, et al.  (2001) A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes. Proc Natl Acad Sci U S A 98(7):3946-51
Tang Y, et al.  (2001) Stabilization of coiled-coil peptide domains by introduction of trifluoroleucine. Biochemistry 40(9):2790-6
Hoffmann B, et al.  (2000) Developmental and metabolic regulation of the phosphoglucomutase-encoding gene, pgmB, of Aspergillus nidulans. Mol Gen Genet 262(6):1001-11
Jia MH, et al.  (2000) Global expression profiling of yeast treated with an inhibitor of amino acid biosynthesis, sulfometuron methyl. Physiol Genomics 3(2):83-92
Kim SJ, et al.  (2000) Random changes of amino acid residues with expected frequency by saturated point mutagenesis. Mol Cells 10(2):232-5
Kiyokawa T, et al.  (2000) Engineering of the hydrophobic core of an alpha-helical coiled coil. Biopolymers 55(5):407-14
Krappmann S, et al.  (2000) Coevolution of transcriptional and allosteric regulation at the chorismate metabolic branch point of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 97(25):13585-90
Meimoun A, et al.  (2000) Degradation of the transcription factor Gcn4 requires the kinase Pho85 and the SCF(CDC4) ubiquitin-ligase complex. Mol Biol Cell 11(3):915-27
Park JM, et al.  (2000) In vivo requirement of activator-specific binding targets of mediator. Mol Cell Biol 20(23):8709-19
Natarajan K, et al.  (1999) Transcriptional activation by Gcn4p involves independent interactions with the SWI/SNF complex and the SRB/mediator. Mol Cell 4(4):657-64
Shu W, et al.  (1999) Trimerization specificity in HIV-1 gp41: analysis with a GCN4 leucine zipper model. Biochemistry 38(17):5378-85
Suckow M, et al.  (1999) A novel feature of DNA recognition: a mutant Gcn4p bZip peptide with dual DNA binding specificities dependent of half-site spacing. J Mol Biol 286(4):983-7
Yu L and Morse RH  (1999) Chromatin opening and transactivator potentiation by RAP1 in Saccharomyces cerevisiae. Mol Cell Biol 19(8):5279-88
Zaman Z, et al.  (1999) Transcription factor GCN4 for control of amino acid biosynthesis also regulates the expression of the gene for lipoamide dehydrogenase. Biochem J 340 ( Pt 3)():855-62
Drysdale CM, et al.  (1998) The Gcn4p activation domain interacts specifically in vitro with RNA polymerase II holoenzyme, TFIID, and the Adap-Gcn5p coactivator complex. Mol Cell Biol 18(3):1711-24
Eckert DM, et al.  (1998) Crystal structure of GCN4-pIQI, a trimeric coiled coil with buried polar residues. J Mol Biol 284(4):859-65