MEC1/YBR136W Literature Guide Help

Other names published for MEC1: ESR1, SAD3, RAD31, YBR136W

MEC1 - Mutants/Phenotypes (305)

ReferenceOther Genes Addressed
Berens TJ and Toczyski DP  (2012) Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo. Mol Biol Cell 23(6):1058-67
Chambers AL, et al.  (2012) The two different isoforms of the RSC chromatin remodeling complex play distinct roles in DNA damage responses. PLoS One 7(2):e32016
Chuang CN, et al.  (2012) Mek1 stabilizes Hop1-Thr318 phosphorylation to promote interhomolog recombination and checkpoint responses during yeast meiosis. Nucleic Acids Res 40(22):11416-27
Collura A, et al.  (2012) Abasic sites linked to dUTP incorporation in DNA are a major cause of spontaneous mutations in absence of base excision repair and Rad17-Mec3-Ddc1 (9-1-1) DNA damage checkpoint clamp in Saccharomyces cerevisiae. DNA Repair (Amst) 11(3):294-303
Cremona CA, et al.  (2012) Extensive DNA damage-induced sumoylation contributes to replication and repair and acts in addition to the mec1 checkpoint. Mol Cell 45(3):422-32
Davidson MB, et al.  (2012) Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype. EMBO J 31(4):895-907
De Piccoli G, et al.  (2012) Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinases. Mol Cell 45(5):696-704
Dion V, et al.  (2012) Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery.LID - 10.1038/ncb2465 [doi] Nat Cell Biol ()
Hashash N, et al.  (2012) Topoisomerase II- and Condensin-Dependent Breakage of MEC1(ATR)-Sensitive Fragile Sites Occurs Independently of Spindle Tension, Anaphase, or Cytokinesis. PLoS Genet 8(10):e1002978
Hector RE, et al.  (2012) Mec1p associates with functionally compromised telomeres. Chromosoma 121(3):277-90
Li J, et al.  (2012) Regulation of Budding Yeast Mating-Type Switching Donor Preference by the FHA Domain of Fkh1. PLoS Genet 8(4):e1002630
Liang D, et al.  (2012) Histone dosage regulates DNA damage sensitivity in a checkpoint-independent manner by the homologous recombination pathway. Nucleic Acids Res 40(19):9604-20
Manfrini N, et al.  (2012) G(1)/S and G(2)/M cyclin-dependent kinase activities commit cells to death in the absence of the S-phase checkpoint. Mol Cell Biol 32(24):4971-85
Poli J, et al.  (2012) dNTP pools determine fork progression and origin usage under replication stress. EMBO J 31(4):883-94
Ribaud V, et al.  (2012) DNA-end capping by the budding yeast transcription factor and subtelomeric binding protein Tbf1. EMBO J 31(1):138-49
Soriano-Carot M, et al.  (2012) The yeast mitogen-activated protein kinase Slt2 is involved in the cellular response to genotoxic stress. Cell Div 7(1):1
Srividya I, et al.  (2012) Yeast transcription termination factor rtt103 functions in DNA damage response. PLoS One 7(2):e31288
Tan FJ, et al.  (2012) DNA resection at chromosome breaks promotes genome stability by constraining non-allelic homologous recombination. PLoS Genet 8(3):e1002633
Tittel-Elmer M, et al.  (2012) Cohesin association to replication sites depends on rad50 and promotes fork restart. Mol Cell 48(1):98-108
Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
Yu S, et al.  (2012) Compromised cellular responses to DNA damage accelerate chronological aging by incurring cell wall fragility in Saccharomyces cerevisiae. Mol Biol Rep 39(4):3573-83
Abba S, et al.  (2011) A PLAC8-containing protein from an endomycorrhizal fungus confers cadmium resistance to yeast cells by interacting with Mlh3p. Nucleic Acids Res 39(17):7548-63
Au TJ, et al.  (2011) ATP-dependent chromatin remodeling factors tune S phase checkpoint activity. Mol Cell Biol 31(22):4454-63
Bermejo R, et al.  (2011) The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. Cell 146(2):233-46
Chen X, et al.  (2011) Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation.LID - 10.1038/nsmb.2105 [doi] Nat Struct Mol Biol ()
Feng W, et al.  (2011) Replication stress-induced chromosome breakage is correlated with replication fork progression and is preceded by single-stranded DNA formation. G3 (Bethesda) 1(5):327-35
Fukunaga K, et al.  (2011) Activation of Protein Kinase Tel1 through Recognition of Protein-Bound DNA Ends. Mol Cell Biol 31(10):1959-71
Gangavarapu V, et al.  (2011) Requirement of replication checkpoint protein kinases mec1/rad53 for postreplication repair in yeast.LID - 10.1128/mBio.00079-11 [doi]LID - e00079-11 [pii] MBio 2(3)
Germann SM, et al.  (2011) Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination. DNA Repair (Amst) 10(2):210-24
Hashash N, et al.  (2011) Regulation of fragile sites expression in budding yeast by MEC1, RRM3 and hydroxyurea. J Cell Sci 124(Pt 2):181-5