MCM5/YLR274W Literature Guide Help

Other names published for MCM5: BOB1, CDC46, YLR274W

MCM5 - Genetic Interactions (31)

ReferenceOther Genes Addressed
Stead BE, et al.  (2011) Phosphorylation of Mcm2 modulates Mcm2-7 activity and affects the cell's response to DNA damage. Nucleic Acids Res 39(16):6998-7008
Espinosa MC, et al.  (2010) GCN5 Is a Positive Regulator of Origins of DNA Replication in Saccharomyces cerevisiae. PLoS One 5(1):e8964
Holzen TM and Sclafani R  (2010) Genetic interaction of RAD53 protein kinase with histones is important for DNA replication. Cell Cycle 9(23):4735-47
Ma L, et al.  (2010) Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae. Cell Cycle 9(21):4399-410
Sheu YJ and Stillman B  (2010) The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4. Nature 463(7277):113-7
Zegerman P and Diffley JF  (2010) Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation. Nature 467(7314):474-8
Rehman MA, et al.  (2009) Subtelomeric ACS-containing proto-silencers act as antisilencers in replication factors mutants in Saccharomyces cerevisiae. Mol Biol Cell 20(2):631-41
Steere NA, et al.  (2009) Functional screen of human MCM2-7 variant alleles for disease-causing potential. Mutat Res 666(1-2):74-8
Tittel-Elmer M, et al.  (2009) The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress. EMBO J 28(8):1142-56
Bochman ML, et al.  (2008) Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability. Mol Cell Biol 28(19):5865-73
Devault A, et al.  (2008) Interplay between S-Cyclin-dependent Kinase and Dbf4-dependent Kinase in Controlling DNA Replication through Phosphorylation of Yeast Mcm4 N-Terminal Domain. Mol Biol Cell 19(5):2267-77
Leon RP, et al.  (2008) Functional Conservation of {beta}-Hairpin DNA Binding Domains in the Mcm Protein of Methanobacterium thermoautotrophicum and the Mcm5 protein of Saccharomyces cerevisiae. Genetics 179(4):1757-68
Lo HC, et al.  (2008) Cdc7-Dbf4 regulates NDT80 transcription as well as reductional segregation during budding yeast meiosis. Mol Biol Cell 19(11):4956-67
Matos J, et al.  (2008) Dbf4-dependent CDC7 kinase links DNA replication to the segregation of homologous chromosomes in meiosis I. Cell 135(4):662-78
Ogi H, et al.  (2008) The role of the Saccharomyces cerevisiae Cdc7-Dbf4 complex in the replication checkpoint. Gene 414(1-2):32-40
Sasanuma H, et al.  (2008) Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination. Genes Dev 22(3):398-410
Bochman ML and Schwacha A  (2007) Differences in the single-stranded DNA binding activities of MCM2-7 and MCM467: MCM2 and MCM5 define a slow ATP-dependent step. J Biol Chem 282(46):33795-804
Dohrmann PR and Sclafani RA  (2006) Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae. Genetics 174(1):87-99
Pessoa-Brandao L and Sclafani RA  (2004) CDC7/DBF4 functions in the translesion synthesis branch of the RAD6 epistasis group in Saccharomyces cerevisiae. Genetics 167(4):1597-610
Wysocka M, et al.  (2004) Saccharomyces cerevisiae CSM1 gene encoding a protein influencing chromosome segregation in meiosis I interacts with elements of the DNA replication complex. Exp Cell Res 294(2):592-602
Dziak R, et al.  (2003) Evidence for a role of MCM (mini-chromosome maintenance)5 in transcriptional repression of sub-telomeric and Ty-proximal genes in Saccharomyces cerevisiae. J Biol Chem 278(30):27372-81
Gauthier L, et al.  (2002) The role of the carboxyterminal domain of RNA polymerase II in regulating origins of DNA replication in Saccharomyces cerevisiae. Genetics 162(3):1117-29
Sclafani RA, et al.  (2002) The mcm5-bob1 bypass of Cdc7p/Dbf4p in DNA replication depends on both Cdk1-independent and Cdk1-dependent steps in Saccharomyces cerevisiae. Genetics 161(1):47-57
Heichman KA and Roberts JM  (1998) CDC16 controls initiation at chromosome replication origins. Mol Cell 1(3):457-63
Hardy CF, et al.  (1997) mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p. Proc Natl Acad Sci U S A 94(7):3151-5
Zou L, et al.  (1997) CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication. Mol Cell Biol 17(2):553-63
Hopwood B and Dalton S  (1996) Cdc45p assembles into a complex with Cdc46p/Mcm5p, is required for minichromosome maintenance, and is essential for chromosomal DNA replication. Proc Natl Acad Sci U S A 93(22):12309-14
Kroll ES, et al.  (1996) Establishing genetic interactions by a synthetic dosage lethality phenotype. Genetics 143(1):95-102
Jackson AL, et al.  (1993) Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. Mol Cell Biol 13(5):2899-908
Hennessy KM, et al.  (1991) A group of interacting yeast DNA replication genes. Genes Dev 5(6):958-69