KAR2/YJL034W Literature Guide Help

Other names published for KAR2: GRP78, BIP, Hsp70 family ATPase KAR2, YJL034W

KAR2 - Genetic Interactions (29)

ReferenceOther Genes Addressed
Stuchell-Brereton MD, et al.  (2011) Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning. Mol Biol Cell 22(15):2690-701
Liu Y and Chang A  (2008) Heat shock response relieves ER stress. EMBO J 27(7):1049-59
Schuldiner M, et al.  (2008) The GET complex mediates insertion of tail-anchored proteins into the ER membrane. Cell 134(4):634-45
Takeuchi M, et al.  (2008) Saccharomyces cerevisiae Rot1 Is an Essential Molecular Chaperone in the Endoplasmic Reticulum. Mol Biol Cell 19(8):3514-25
Carla Fama M, et al.  (2007) The Saccharomyces cerevisiae YFR041C/ERJ5 gene encoding a type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum. Biochim Biophys Acta 1773(2):232-42
Takeuchi M, et al.  (2006) Causal links between protein folding in the ER and events along the secretory pathway. Autophagy 2(4):323-4
Takeuchi M, et al.  (2006) Saccharomyces cerevisiae Rot1p is an ER-localized membrane protein that may function with BiP/Kar2p in protein folding. J Biochem 139(3):597-605
Xu P, et al.  (2005) Analysis of unfolded protein response during single-chain antibody expression in Saccaromyces cerevisiae reveals different roles for BiP and PDI in folding. Metab Eng 7(4):269-79
Huyer G, et al.  (2004) Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein. J Biol Chem 279(37):38369-78
Kimata Y, et al.  (2004) A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1. J Cell Biol 167(3):445-56
Kabani M, et al.  (2003) Dependence of endoplasmic reticulum-associated degradation on the peptide binding domain and concentration of BiP. Mol Biol Cell 14(8):3437-48
Palmer EA, et al.  (2003) Differential requirements of novel A1PiZ degradation deficient (ADD) genes in ER-associated protein degradation. J Cell Sci 116(Pt 11):2361-73
Casagrande R, et al.  (2000) Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway. Mol Cell 5(4):729-35
Kabani M, et al.  (2000) Sls1p stimulates Sec63p-mediated activation of Kar2p in a conformation-dependent manner in the yeast endoplasmic reticulum. Mol Cell Biol 20(18):6923-34
Ng DT, et al.  (2000) The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control. J Cell Biol 150(1):77-88
Brizzio V, et al.  (1999) Genetic interactions between KAR7/SEC71, KAR8/JEM1, KAR5, and KAR2 during nuclear fusion in Saccharomyces cerevisiae. Mol Biol Cell 10(3):609-26
Brodsky JL, et al.  (1999) The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct. J Biol Chem 274(6):3453-60
Kasuya T, et al.  (1999) Cloning and characterization of the bipA gene encoding ER chaperone BiP from Aspergillus oryzae. J Biosci Bioeng 88(5):472-8
Umebayashi K, et al.  (1999) Unfolded protein response-induced BiP/Kar2p production protects cell growth against accumulation of misfolded protein aggregates in the yeast endoplasmic reticulum. Eur J Cell Biol 78(10):726-38
Ogg SC, et al.  (1998) A functional GTPase domain, but not its transmembrane domain, is required for function of the SRP receptor beta-subunit. J Cell Biol 142(2):341-54
Silberstein S, et al.  (1998) A role for the DnaJ homologue Scj1p in protein folding in the yeast endoplasmic reticulum. J Cell Biol 143(4):921-33
Simons JF, et al.  (1998) Cell wall 1,6-beta-glucan synthesis in Saccharomyces cerevisiae depends on ER glucosidases I and II, and the molecular chaperone BiP/Kar2p. EMBO J 17(2):396-405
Baxter BK, et al.  (1996) SSI1 encodes a novel Hsp70 of the Saccharomyces cerevisiae endoplasmic reticulum. Mol Cell Biol 16(11):6444-56
Craven RA, et al.  (1996) A novel Hsp70 of the yeast ER lumen is required for the efficient translocation of a number of protein precursors. EMBO J 15(11):2640-50
Hamilton TG and Flynn GC  (1996) Cer1p, a novel Hsp70-related protein required for posttranslational endoplasmic reticulum translocation in yeast. J Biol Chem 271(48):30610-3
Harmsen MM, et al.  (1996) Overexpression of binding protein and disruption of the PMR1 gene synergistically stimulate secretion of bovine prochymosin but not plant thaumatin in yeast. Appl Microbiol Biotechnol 46(4):365-70
Sidrauski C, et al.  (1996) tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell 87(3):405-13
Lyman SK and Schekman R  (1995) Interaction between BiP and Sec63p is required for the completion of protein translocation into the ER of Saccharomyces cerevisiae. J Cell Biol 131(5):1163-71
Demolder J, et al.  (1994) Human interferon-beta, expressed in Saccharomyces cerevisiae, is predominantly directed to the vacuoles. Influence of modified co-expression of secretion factors and chaperones. J Biotechnol 32(2):179-89