PRP8/YHR165C Literature Guide Help

Other names published for PRP8: DBF3, DNA39, RNA8, SLT21, USA2, YHR165C

PRP8 - Genetic Interactions (27)

ReferenceOther Genes Addressed
Query CC and Konarska MM  (2012) CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome. RNA 18(5):1001-13
Pandit S, et al.  (2009) Spp382p interacts with multiple yeast splicing factors, including possible regulators of Prp43 DExD/H-Box protein function. Genetics 183(1):195-206
Aronova A, et al.  (2007) Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing. RNA 13(9):1437-44
Kaplan Y and Kupiec M  (2007) A role for the yeast cell cycle/splicing factor Cdc40 in the G(1)/S transition. Curr Genet 51(2):123-40
Liu L, et al.  (2007) Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing. Nat Struct Mol Biol 14(6):519-26
Bellare P, et al.  (2006) Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p. RNA 12(2):292-302
Konarska MM, et al.  (2006) Repositioning of the reaction intermediate within the catalytic center of the spliceosome. Mol Cell 21(4):543-53
Brenner TJ and Guthrie C  (2005) Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation. Genetics 170(3):1063-80
Query CC and Konarska MM  (2004) Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants. Mol Cell 14(3):343-54
Schneider S, et al.  (2004) Motifs IV and V in the DEAH box splicing factor Prp22 are important for RNA unwinding, and helicase-defective Prp22 mutants are suppressed by Prp8. J Biol Chem 279(10):8617-26
Kuhn AN, et al.  (2002) Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation. Proc Natl Acad Sci U S A 99(14):9145-9
Dagher SF and Fu XD  (2001) Evidence for a role of Sky1p-mediated phosphorylation in 3' splice site recognition involving both Prp8 and Prp17/Slu4. RNA 7(9):1284-97
Ben-Yehuda S, et al.  (2000) Extensive genetic interactions between PRP8 and PRP17/CDC40, two yeast genes involved in pre-mRNA splicing and cell cycle progression. Genetics 154(1):61-71
Ben-Yehuda S, et al.  (2000) Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae. Genetics 156(4):1503-17
Kuhn AN and Brow DA  (2000) Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation. Genetics 155(4):1667-82
Collins CA and Guthrie C  (1999) Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome. Genes Dev 13(15):1970-82
Kuhn AN, et al.  (1999) Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome. Mol Cell 3(1):65-75
Siatecka M, et al.  (1999) Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center. Genes Dev 13(15):1983-93
Xu D, et al.  (1998) Synthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicing. Mol Cell Biol 18(4):2055-66
Umen JG and Guthrie C  (1996) Mutagenesis of the yeast gene PRP8 reveals domains governing the specificity and fidelity of 3' splice site selection. Genetics 143(2):723-39
Shea JE, et al.  (1994) The budding yeast U5 snRNP Prp8 is a highly conserved protein which links RNA splicing with cell cycle progression. Nucleic Acids Res 22(25):5555-64
Frank D, et al.  (1992) Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing. Mol Cell Biol 12(11):5197-205
Jamieson DJ and Beggs JD  (1991) A suppressor of yeast spp81/ded1 mutations encodes a very similar putative ATP-dependent RNA helicase. Mol Microbiol 5(4):805-12
Jamieson DJ, et al.  (1991) A suppressor of a yeast splicing mutation (prp8-1) encodes a putative ATP-dependent RNA helicase. Nature 349(6311):715-7
Strauss EJ and Guthrie C  (1991) A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family. Genes Dev 5(4):629-41
Jackson SP, et al.  (1988) Cloning of the RNA8 gene of Saccharomyces cerevisiae, detection of the RNA8 protein, and demonstration that it is essential for nuclear pre-mRNA splicing. Mol Cell Biol 8(3):1067-75
Pearson NJ, et al.  (1982) A suppressor of temperature-sensitive rna mutations that affect mRNA metabolism in Saccharomyces cerevisiae. Mol Cell Biol 2(5):571-77