MOT2/YER068W Literature Guide Help

Other names published for MOT2: NOT4, SIG1, CCR4-NOT core ubiquitin-protein ligase subunit MOT2, YER068W

MOT2 - Genetic Interactions (25)

ReferenceOther Genes Addressed
Cooper KF, et al.  (2012) Oxidative-stress-induced nuclear to cytoplasmic relocalization is required for Not4-dependent cyclin C destruction. J Cell Sci 125(Pt 4):1015-26
Lanza AM, et al.  (2012) Linking yeast Gcn5p catalytic function and gene regulation using a quantitative, graded dominant mutant approach. PLoS One 7(4):e36193
Assenholt J, et al.  (2011) Implication of Ccr4-Not complex function in mRNA quality control in Saccharomyces cerevisiae. RNA 17(10):1788-94
Ito W, et al.  (2011) RNA-binding protein Khd1 and Ccr4 deadenylase play overlapping roles in the cell wall integrity pathway in Saccharomyces cerevisiae. Eukaryot Cell 10(10):1340-7
Kerr SC, et al.  (2011) The ccr4-not complex interacts with the mRNA export machinery. PLoS One 6(3):e18302
Panasenko OO and Collart MA  (2011) Not4 E3 ligase contributes to proteasome assembly and functional integrity in part through Ecm29. Mol Cell Biol 31(8):1610-23
Haworth J, et al.  (2010) Ubc4 and Not4 Regulate Steady-State Levels of DNA Polymerase-{alpha} to Promote Efficient and Accurate DNA Replication. Mol Biol Cell 21(18):3205-19
Azzouz N, et al.  (2009) The CCR4-NOT complex physically and functionally interacts with TRAMP and the nuclear exosome. PLoS One 4(8):e6760
Mersman DP, et al.  (2009) Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression. Genes Dev 23(8):951-62
Panasenko OO, et al.  (2009) Ribosome association and stability of the nascent polypeptide-associated complex is dependent upon its own ubiquitination. Genetics 181(2):447-60
Saguez C, et al.  (2008) Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylation. Mol Cell 31(1):91-103
Lenssen E, et al.  (2007) The Ccr4-Not Complex Regulates Skn7 through Srb10 Kinase. Eukaryot Cell 6(12):2251-9
Mulder KW, et al.  (2007) Modulation of Ubc4p/Ubc5p-Mediated Stress Responses by the RING-Finger-Dependent Ubiquitin-Protein Ligase Not4p in Saccharomyces cerevisiae. Genetics 176(1):181-92
Mulder KW, et al.  (2007) Regulation of histone H3K4 tri-methylation and PAF complex recruitment by the Ccr4-Not complex. Nucleic Acids Res 35(7):2428-39
Biswas D, et al.  (2006) Genetic interactions between Nhp6 and Gcn5 with Mot1 and the Ccr4-Not complex that regulate binding of TATA-binding protein in Saccharomyces cerevisiae. Genetics 172(2):837-49
Mulder KW, et al.  (2005) DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex. Nucleic Acids Res 33(19):6384-92
Deluen C, et al.  (2002) The Ccr4-not complex and yTAF1 (yTaf(II)130p/yTaf(II)145p) show physical and functional interactions. Mol Cell Biol 22(19):6735-49
Denis CL, et al.  (2001) Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation. Genetics 158(2):627-34
Badarinarayana V, et al.  (2000) Functional interaction of CCR4-NOT proteins with TATAA-binding protein (TBP) and its associated factors in yeast. Genetics 155(3):1045-54
Lemaire M and Collart MA  (2000) The TATA-binding protein-associated factor yTafII19p functionally interacts with components of the global transcriptional regulator Ccr4-Not complex and physically interacts with the Not5 subunit. J Biol Chem 275(35):26925-34
Bai Y, et al.  (1999) The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5. Mol Cell Biol 19(10):6642-51
Oberholzer U and Collart MA  (1998) Characterization of NOT5 that encodes a new component of the Not protein complex. Gene 207(1):61-9
Cade RM and Errede B  (1994) MOT2 encodes a negative regulator of gene expression that affects basal expression of pheromone-responsive genes in Saccharomyces cerevisiae. Mol Cell Biol 14(5):3139-49
Collart MA and Struhl K  (1994) NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization. Genes Dev 8(5):525-37
Irie K, et al.  (1994) The yeast MOT2 gene encodes a putative zinc finger protein that serves as a global negative regulator affecting expression of several categories of genes, including mating-pheromone-responsive genes. Mol Cell Biol 14(5):3150-7