SIR2/YDL042C Literature Guide Help

Other names published for SIR2: MAR1, YDL042C

SIR2 - Function/Process (232)

ReferenceOther Genes Addressed
Kozak ML, et al.  (2010) Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction. EMBO J 29(1):158-70
Chen XF, et al.  (2009) Telomere recombination accelerates cellular aging in Saccharomyces cerevisiae. PLoS Genet 5(6):e1000535
Dang W, et al.  (2009) Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature 459(7248):802-7
Du J, et al.  (2009) Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD. Biochemistry 48(13):2878-90
Hontz RD, et al.  (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19
Lin YY, et al.  (2009) Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell 136(6):1073-84
Loney ER, et al.  (2009) Repressive and non-repressive chromatin at native telomeres in Saccharomyces cerevisiae. Epigenetics Chromatin 2(1):18
Marvin ME, et al.  (2009) The association of yKu with subtelomeric core X sequences prevents recombination involving telomeric sequences. Genetics 183(2):453-67, 1SI-13SI
Sanders BD, et al.  (2009) Identification and characterization of novel sirtuin inhibitor scaffolds. Bioorg Med Chem 17(19):7031-41
Sinha M, et al.  (2009) Recombinational repair within heterochromatin requires ATP-dependent chromatin remodeling. Cell 138(6):1109-21
Smith Jr DL, et al.  (2009) Calorie restriction effects on silencing and recombination at the yeast rDNA. Aging Cell 8(6):633-642
Zhou J, et al.  (2009) Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. Nucleic Acids Res 37(11):3699-713
Borner GV, et al.  (2008) Yeast Pch2 promotes domainal axis organization, timely recombination progression, and arrest of defective recombinosomes during meiosis. Proc Natl Acad Sci U S A 105(9):3327-32
Casper AM, et al.  (2008) Low Levels of DNA Polymerase Alpha Induce Mitotic and Meiotic Instability in the Ribosomal DNA Gene Cluster of Saccharomyces cerevisiae. PLoS Genet 4(6):e1000105
Chou CC, et al.  (2008) Bypassing Sir2 and O-acetyl-ADP-ribose in transcriptional silencing. Mol Cell 31(5):650-9
Gao L and Gross DS  (2008) Sir2 silences gene transcription by targeting the transition between RNA polymerase II initiation and elongation. Mol Cell Biol 28(12):3979-94
Lain S, et al.  (2008) Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13(5):454-63
Lee S, et al.  (2008) Quantification of endogenous sirtuin metabolite O-acetyl-ADP-ribose. Anal Biochem 383(2):174-9
Li C, et al.  (2008) Linker histone H1 represses recombination at the ribosomal DNA locus in the budding yeast Saccharomyces cerevisiae. Mol Microbiol 67(4):906-19
Vasiljeva L, et al.  (2008) Transcription Termination and RNA Degradation Contribute to Silencing of RNA Polymerase II Transcription within Heterochromatin. Mol Cell 29(3):313-23
Yang B, et al.  (2008) HST3/HST4-dependent deacetylation of lysine 56 of histone H3 in silent chromatin. Mol Biol Cell 19(11):4993-5005
Erjavec N and Nystrom T  (2007) Sir2p-dependent protein segregation gives rise to a superior reactive oxygen species management in the progeny of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 104(26):10877-81
Hickman M, et al.  (2007) Isolation and Characterization of Conditional Alleles of the Yeast SIR2 Gene. J Mol Biol 367(5):1246-57
Hickman MA and Rusche LN  (2007) Substitution as a mechanism for genetic robustness: the duplicated deacetylases Hst1p and Sir2p in Saccharomyces cerevisiae. PLoS Genet 3(8):e126
Huang S, et al.  (2007) A novel role for histone chaperones CAF-1 and Rtt106p in heterochromatin silencing. EMBO J 26(9):2274-83
Mead J, et al.  (2007) Swapping the gene-specific and regional silencing specificities of the Hst1 and Sir2 histone deacetylases. Mol Cell Biol 27(7):2466-75
Onishi M, et al.  (2007) Role of the Conserved Sir3-BAH Domain in Nucleosome Binding and Silent Chromatin Assembly. Mol Cell 28(6):1015-28
Sun Q, et al.  (2007) Valproate induces apoptosis by inducing accumulation of neutral lipids which was prevented by disruption of the SIR2 gene in Saccharomyces cerevisiae. FEBS Lett 581(21):3991-3995
Thaminy S, et al.  (2007) Hst3 Is Regulated by Mec1-dependent Proteolysis and Controls the S Phase Checkpoint and Sister Chromatid Cohesion by Deacetylating Histone H3 at Lysine 56. J Biol Chem 282(52):37805-14
Xu F, et al.  (2007) Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast. Mol Cell 27(6):890-900