PRP16/YKR086W Literature Guide Help

Other names published for PRP16: RNA16, PRP23, DEAH-box RNA helicase PRP16, YKR086W

PRP16 - Function/Process (27)

ReferenceOther Genes Addressed
Koodathingal P, et al.  (2010) The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicing. Mol Cell 39(3):385-95
Warkocki Z, et al.  (2009) Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components. Nat Struct Mol Biol 16(12):1237-43
Schwer B  (2008) A conformational rearrangement in the spliceosome sets the stage for Prp22-dependent mRNA release. Mol Cell 30(6):743-54
Pleiss JA, et al.  (2007) Transcript specificity in yeast pre-mRNA splicing revealed by mutations in core spliceosomal components. PLoS Biol 5(4):e90
Villa T and Guthrie C  (2005) The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing. Genes Dev 19(16):1894-904
Query CC and Konarska MM  (2004) Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants. Mol Cell 14(3):343-54
Chawla G, et al.  (2003) Dependence of pre-mRNA introns on PRP17, a non-essential splicing factor: implications for efficient progression through cell cycle transitions. Nucleic Acids Res 31(9):2333-43
McPheeters DS and Muhlenkamp P  (2003) Spatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast. Mol Cell Biol 23(12):4174-86
Schneider S, et al.  (2002) Characterization of dominant-negative mutants of the DEAH-box splicing factors Prp22 and Prp16. J Biol Chem 277(18):15452-8
Biggins S, et al.  (2001) Genes involved in sister chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae. Genetics 159(2):453-70
van Nues RW and Beggs JD  (2001) Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae. Genetics 157(4):1451-67
Ben-Yehuda S, et al.  (2000) Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae. Genetics 156(4):1503-17
Brodsky AS and Silver PA  (2000) Pre-mRNA processing factors are required for nuclear export. RNA 6(12):1737-49
McPheeters DS, et al.  (2000) Interaction of the yeast DExH-box RNA helicase prp22p with the 3' splice site during the second step of nuclear pre-mRNA splicing. Nucleic Acids Res 28(6):1313-21
Chanfreau G, et al.  (1999) Trans-complementation of the second step of pre-mRNA splicing by exogenous 5' exons. RNA 5(7):876-82
Kim DH and Rossi JJ  (1999) The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex. RNA 5(7):959-71
Lindsey LA and Garcia-Blanco MA  (1998) Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p. J Biol Chem 273(49):32771-5
Wang Y and Guthrie C  (1998) PRP16, a DEAH-box RNA helicase, is recruited to the spliceosome primarily via its nonconserved N-terminal domain. RNA 4(10):1216-29
Wang Y, et al.  (1998) The DEAH-box splicing factor Prp16 unwinds RNA duplexes in vitro. Curr Biol 8(8):441-51
Brys A and Schwer B  (1996) Requirement for SLU7 in yeast pre-mRNA splicing is dictated by the distance between the branchpoint and the 3' splice site. RNA 2(7):707-17
Ansari A and Schwer B  (1995) SLU7 and a novel activity, SSF1, act during the PRP16-dependent step of yeast pre-mRNA splicing. EMBO J 14(16):4001-9
Umen JG and Guthrie C  (1995) Prp16p, Slu7p, and Prp8p interact with the 3' splice site in two distinct stages during the second catalytic step of pre-mRNA splicing. RNA 1(6):584-97
Burgess SM and Guthrie C  (1993) A mechanism to enhance mRNA splicing fidelity: the RNA-dependent ATPase Prp16 governs usage of a discard pathway for aberrant lariat intermediates. Cell 73(7):1377-91
Schwer B and Guthrie C  (1992) A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis. EMBO J 11(13):5033-9
Schwer B and Guthrie C  (1992) A dominant negative mutation in a spliceosomal ATPase affects ATP hydrolysis but not binding to the spliceosome. Mol Cell Biol 12(8):3540-7
Schwer B and Guthrie C  (1991) PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome. Nature 349(6309):494-9
Couto JR, et al.  (1987) A trans-acting suppressor restores splicing of a yeast intron with a branch point mutation. Genes Dev 1(5):445-55