MEC1/YBR136W Literature Guide Help

Other names published for MEC1: ESR1, SAD3, RAD31, YBR136W

MEC1 - Function/Process (201)

ReferenceOther Genes Addressed
De Piccoli G, et al.  (2012) Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinases. Mol Cell 45(5):696-704
Dion V, et al.  (2012) Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery.LID - 10.1038/ncb2465 [doi] Nat Cell Biol ()
Li J, et al.  (2012) Regulation of Budding Yeast Mating-Type Switching Donor Preference by the FHA Domain of Fkh1. PLoS Genet 8(4):e1002630
Manfrini N, et al.  (2012) G(1)/S and G(2)/M cyclin-dependent kinase activities commit cells to death in the absence of the S-phase checkpoint. Mol Cell Biol 32(24):4971-85
Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
Gangavarapu V, et al.  (2011) Requirement of replication checkpoint protein kinases mec1/rad53 for postreplication repair in yeast.LID - 10.1128/mBio.00079-11 [doi]LID - e00079-11 [pii] MBio 2(3)
Searle JS, et al.  (2011) Proteins in the Nutrient-Sensing and DNA Damage Checkpoint Pathways Cooperate to Restrain Mitotic Progression following DNA Damage. PLoS Genet 7(7):e1002176
Zhang L, et al.  (2011) Meiotic double-strand breaks occur once per pair of (sister) chromatids and, via Mec1/ATR and Tel1/ATM, once per quartet of chromatids. Proc Natl Acad Sci U S A 108(50):20036-41
Fasullo M, et al.  (2010) Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants. Nucleic Acids Res 38(4):1195-203
Janke R, et al.  (2010) A truncated DNA-damage-signaling response is activated after DSB formation in the G1 phase of Saccharomyces cerevisiae. Nucleic Acids Res 38(7):2302-13
Kaochar S, et al.  (2010) Checkpoint genes and Exo1 regulate nearby inverted repeat fusions that form dicentric chromosomes in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 107(50):21605-10
Lopez-Mosqueda J, et al.  (2010) Cdc5 blocks in vivo Rad53 activity, but not in situ activity (ISA). Cell Cycle 9(21):4266-8
McCulley JL and Petes TD  (2010) Chromosome rearrangements and aneuploidy in yeast strains lacking both Tel1p and Mec1p reflect deficiencies in two different mechanisms. Proc Natl Acad Sci U S A 107(25):11465-70
Nguyen VC, et al.  (2010) Replication stress checkpoint signaling controls tRNA gene transcription. Nat Struct Mol Biol 17(8):976-81
Ohouo PY, et al.  (2010) DNA damage signaling recruits the Rtt107-Slx4 scaffolds via Dpb11 to mediate replication stress response. Mol Cell 39(2):300-6
Palou G, et al.  (2010) Cyclin regulation by the s phase checkpoint. J Biol Chem 285(34):26431-40
Randell JC, et al.  (2010) Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7. Mol Cell 40(3):353-63
Taschner M, et al.  (2010) A role for checkpoint kinase-dependent Rad26 phosphorylation in transcription-coupled DNA repair in Saccharomyces cerevisiae. Mol Cell Biol 30(2):436-46
Toh GW, et al.  (2010) Mec1/Tel1-dependent phosphorylation of Slx4 stimulates Rad1-Rad10-dependent cleavage of non-homologous DNA tails. DNA Repair (Amst) 9(6):718-26
Vidanes GM, et al.  (2010) CDC5 Inhibits the Hyperphosphorylation of the Checkpoint Kinase Rad53, Leading to Checkpoint Adaptation. PLoS Biol 8(1):e1000286
Zhang W and Durocher D  (2010) De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks. Genes Dev 24(5):502-15
Agmon N, et al.  (2009) Analysis of repair mechanism choice during homologous recombination. Nucleic Acids Res 37(15):5081-92
Enserink JM, et al.  (2009) Cdc28/Cdk1 positively and negatively affects genome stability in S. cerevisiae. J Cell Biol 185(3):423-37
Feng W, et al.  (2009) Centromere replication timing determines different forms of genomic instability in Saccharomyces cerevisiae checkpoint mutants during replication stress. Genetics 183(4):1249-60
Makovets S and Blackburn EH  (2009) DNA damage signalling prevents deleterious telomere addition at DNA breaks. Nat Cell Biol 11(11):1383-6
Naylor ML, et al.  (2009) Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork. Proc Natl Acad Sci U S A 106(31):12765-70
Truman AW, et al.  (2009) Mechanism of Mpk1 mitogen-activated protein kinase binding to the Swi4 transcription factor and its regulation by a novel caffeine-induced phosphorylation. Mol Cell Biol 29(24):6449-61
Usui T, et al.  (2009) Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization. Mol Cell 33(2):147-59
Cartagena-Lirola H, et al.  (2008) Role of the Saccharomyces cerevisiae Rad53 checkpoint kinase in signaling double-strand breaks during the meiotic cell cycle. Mol Cell Biol 28(14):4480-93
Clerici M, et al.  (2008) The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle. EMBO Rep 9(8):810-8