MCM4/YPR019W Literature Guide Help

Other names published for MCM4: HCD21, CDC54, YPR019W

MCM4 - Function/Process (38)

ReferenceOther Genes Addressed
Blitzblau HG, et al.  (2012) Separation of DNA replication from the assembly of break-competent meiotic chromosomes. PLoS Genet 8(5):e1002643
Zhang Y, et al.  (2012) Genome-wide screen identifies pathways that govern GAA/TTC repeat fragility and expansions in dividing and nondividing yeast cells. Mol Cell 48(2):254-65
Li XC and Tye BK  (2011) Ploidy Dictates Repair Pathway Choice under DNA Replication Stress. Genetics 187(4):1031-40
Stead BE, et al.  (2011) Phosphorylation of Mcm2 modulates Mcm2-7 activity and affects the cell's response to DNA damage. Nucleic Acids Res 39(16):6998-7008
Bochman ML and Schwacha A  (2010) The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'. Nucleic Acids Res 38(18):6078-88
Lydeard JR, et al.  (2010) Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly. Genes Dev 24(11):1133-44
Sheu YJ and Stillman B  (2010) The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4. Nature 463(7277):113-7
Tsakraklides V and Bell SP  (2010) Dynamics of pre-replicative complex assembly. J Biol Chem 285(13):9437-43
Snyder M, et al.  (2009) The Minichromosome Maintenance Proteins 2-7 (MCM2-7) Are Necessary for RNA Polymerase II (Pol II)-mediated Transcription. J Biol Chem 284(20):13466-72
Stead BE, et al.  (2009) ATP binding and hydrolysis by Mcm2 regulate DNA binding by Mcm complexes. J Mol Biol 391(2):301-13
Bochman ML and Schwacha A  (2008) The Mcm2-7 complex has in vitro helicase activity. Mol Cell 31(2):287-93
Bochman ML, et al.  (2008) Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability. Mol Cell Biol 28(19):5865-73
Kanter DM, et al.  (2008) Mcm subunits can assemble into two different active unwinding complexes. J Biol Chem 283(45):31172-82
Bochman ML and Schwacha A  (2007) Differences in the single-stranded DNA binding activities of MCM2-7 and MCM467: MCM2 and MCM5 define a slow ATP-dependent step. J Biol Chem 282(46):33795-804
Shima N, et al.  (2007) A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice. Nat Genet 39(1):93-8
Gambus A, et al.  (2006) GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol 8(4):358-66
Green BM, et al.  (2006) Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant. Mol Biol Cell 17(5):2401-14
Kawasaki Y, et al.  (2006) Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro. Genes Cells 11(7):745-56
Tanny RE, et al.  (2006) Genome-wide analysis of re-replication reveals inhibitory controls that target multiple stages of replication initiation. Mol Biol Cell 17(5):2415-23
Yu L, et al.  (2006) A survey of essential gene function in the yeast cell division cycle. Mol Biol Cell 17(11):4736-47
Biswas-Fiss EE, et al.  (2005) The Mcm467 complex of Saccharomyces cerevisiae is preferentially activated by autonomously replicating DNA sequences. Biochemistry 44(8):2916-25
Mitkova AV, et al.  (2005) Modulation of DNA synthesis in Saccharomyces cerevisiae nuclear extract by DNA polymerases and the origin recognition complex. J Biol Chem 280(8):6285-92
Bowers JL, et al.  (2004) ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication. Mol Cell 16(6):967-78
Dasgupta A, et al.  (2004) Sir Antagonist 1 (San1) is a ubiquitin ligase. J Biol Chem 279(26):26830-8
Davey MJ, et al.  (2003) Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture. J Biol Chem 278(7):4491-9
Kaplan DL, et al.  (2003) Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex. J Biol Chem 278(49):49171-82
Labib K, et al.  (2001) MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint. Mol Biol Cell 12(11):3658-67
Nguyen VQ, et al.  (2001) Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms. Nature 411(6841):1068-73
Schwacha A and Bell SP  (2001) Interactions between two catalytically distinct MCM subgroups are essential for coordinated ATP hydrolysis and DNA replication. Mol Cell 8(5):1093-104
Homesley L, et al.  (2000) Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins. Genes Dev 14(8):913-26