LEU2/YCL018W Literature Guide Help

Other names published for LEU2: 3-isopropylmalate dehydrogenase, YCL018W

LEU2 - Function/Process (17)

ReferenceOther Genes Addressed
Hueso G, et al.  (2012) A novel role for protein kinase Gcn2 in yeast tolerance to intracellular acid stress. Biochem J 441(1):255-64
Alvers AL, et al.  (2009) Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae. Aging Cell 8(4):353-69
Rossignol T, et al.  (2009) The proteome of a wine yeast strain during fermentation, correlation with the transcriptome. J Appl Microbiol 107(1):47-55
Cohen R and Engelberg D  (2007) Commonly used Saccharomyces cerevisiae strains (e.g. BY4741, W303) are growth sensitive on synthetic complete medium due to poor leucine uptake. FEMS Microbiol Lett 273(2):239-43
Shi F, et al.  (2005) Identification of ATP-NADH kinase isozymes and their contribution to supply of NADP(H) in Saccharomyces cerevisiae. FEBS J 272(13):3337-49
Kohlhaw GB  (2003) Leucine biosynthesis in fungi: entering metabolism through the back door. Microbiol Mol Biol Rev 67(1):1-15, table of contents
Goldstein AL and McCusker JH  (2001) Development of Saccharomyces cerevisiae as a model pathogen. A system for the genetic identification of gene products required for survival in the mammalian host environment. Genetics 159(2):499-513
Tamakoshi M, et al.  (2001) Selection of stabilized 3-isopropylmalate dehydrogenase of Saccharomyces cerevisiae using the host-vector system of an extreme thermophile, Thermus thermophilus. Extremophiles 5(1):17-22
Casey GP and Pedersen MB  (1988) DNA sequence polymorphisms in the genus Saccharomyces. V. Cloning and characterization of a LEU2 gene from S. carlsbergensis. Carlsberg Res Commun 53(3):209-19
Kohlhaw GB  (1988) Beta-isopropylmalate dehydrogenase from yeast. Methods Enzymol 166:429-35
Baichwal V, et al.  (1983) Leucine biosynthesis in yeast. Identification of two genes (LEU4, LEU5) that affect alpha-Isopropylmalate synthase activity and evidence that LEU1 and LEU2 gene expression is controlled by alpha-Isopropylmalate and the product of a regulatory gene. Curr Genet 7(5):369-377
Hsu YP and Kohlhaw GB  (1982) Overproduction and control of the LEU2 gene product, beta-isopropylmalate dehydrogenase, in transformed yeast strains. J Biol Chem 257(1):39-41
Jones EW and Fink GR  (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
Hsu YP and Kohlhaw GB  (1980) Leucine biosynthesis in Saccharomyces cerevisiae. Purification and characterization of beta-isopropylmalate dehydrogenase. J Biol Chem 255(15):7255-60
Ryan ED, et al.  (1973) Subcellular localization of the leucine biosynthetic enzymes in yeast. J Bacteriol 116(1):222-5
Meuris P  (1969) Studies of mutants inhibited by their own metabolites in Saccharomyces cerevisiae. II. Genetic and enzymatic analysis of three classes of mutants. Genetics 63(3):569-80
Satyanarayana T, et al.  (1968) Biosynthesis of branched-chain amino acids in yeast: correlation of biochemical blocks and genetic lesions in leucine auxotrophs. J Bacteriol 96(6):2012-7